Clinicopathological characteristics of miscarriages featuring placental massive perivillous fibrin deposition

Chronic histiocytic intervillositis: A breakdown in immune tolerance comparable to allograft rejection?

“…• • Association with autoimmune disease/autoantibodies 111 • C4d deposition 121 • Increased anti-HLA antibodies 88,121 • Increased inflammatory chemokine expression 88 Note: Chronic histiocytic intervillositis (CHI), villitis of unknown aetiology (VUE) and massive perivillous fibrin deposition (MPFD/MFI) have reported overlaps in pathology, with evidence of suggested immune involvement and rejection.…”

3D Pancreatic Tissue Modeling in vitro: Advances and Prospects

“…dECM, which contains intrinsic biochemical signature of native tissue, has been applied to tissue regeneration and in vitro modeling as a functional biomaterial 23,24,37,[75][76][77][78] . Recently, Han et al reported that target tissue-specific compositional patterns of dECM can affect transcriptome profile (e.g., gene expression and differentiation) of human bone marrow MSCs (hBMMSCs) in response to various dECMs 22 .…”

“…These results demonstrated the significance of target tissue modeling with the native tissue microenvironment. In this regard, Kim et al developed the process for making pancreatic tissue-derived dECM (pdECM) (Figure 3A-a) and showed that pdECM preserves inherited ECM proteins while removing cellular components (Figure 3A-b), and the biochemical cues from conserved proteins enhance the functional stability in glucose responsiveness (Figure 3A-d) and viability (Figure 3A-c) over typical biomaterials 23,24,64,78 . Recently, Giobbe et al succeeded in organogenesis of complex human endoderm, including small intestine (SI), liver, stomach, and pancreas using intestinal tissue-derived dECM, which is compatible with the ordinary Matrigel condition (Figure 3B).…”

“…Daoud et al reported that an in vitro culture platform for human pancreatic islets needs biologically supportive 3D architecture to prevent progressive loss of islets functionality and compensate for the absence of peripheral basement membranes 21 . Especially, tissue-derived extracellular matrix (ECM) material can be a promising constituent to build functional tissue constructs in terms of creating an environment to enable diverse tissue-specific signals for improving cell-material interaction [22][23][24] . Moreover, emergence of biofabrication approaches including organs-on-chips and 3D bioprinting have broadened the application of functional tissue generation in vitro 9,25 .…”

Extending the Spectrum of Massive Perivillous Fibrin Deposition (Maternal Floor Infarction)

“…[5][6][7][8][9] Several of these conditions have an underlying immune etiology, and this pathogenesis is supported by the finding of C4d deposition on affected trophoblast in recurrent miscarriages with MPVF and the occasional overlap of MPVF with CHI. 10 One unifying hypothesis is that fibrin deposition and intervillous inflammation represent distinct, but overlapping, responses to trophoblast injury. Both are usually limited in extent, but in the face of a dysfunctional maternal inflammatory response, both may progress to involve a large portion of the intervillous space resulting in pregnancy loss.…”