Clinicopathological characteristics of patients with nivolumab-induced pneumonitis

Abstract

Results: Exomes were sequenced with an average base coverage of 117.9x, a mean of 93.5% of the target sequence was covered to a depth of at least 20x, and uniformity of base coverage was 92.7%. We identified a mean of 49.8 nonsynonymous mutations per sample (range 2-136) with RPM!1. We predicted a mean of 37.8 candidate epitopes/ sample (3-90) with binding affinity of less than 500nM with NetMHC. Conclusion:We have established a screening system of candidate cancer neoantigens whose immunogenecity should be further validated by the cytotoxic T lymphocytes (CTL) induction system.