Clinicopathological characteristics of subcentimeter adenocarcinomas of the lung

Kato, Fumiki; Hamasaki, Makoto; Miyake, Yoshihiro; Iwasaki, Atsushi; Iwasaki, Hiroshi; Nabeshima, Kazuki

doi:10.1016/j.lungcan.2012.05.109

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…The clinicopathological characteristics of subcentimeter lung adenocarcinomas has been already well-defined [7,24,25]; however, its radiographic features has been rarely reported. Wu et al investigated the CT features of subcentimeter pure GGNs (pGGNs) and concluded that vessel changes, unsmooth margin, and clear lung-tumor interface may all indicate the invasiveness of subcentimeter pGGNs [26]; yet, his study included only pGGNs and a small sample size (150 lesions).…”

Section: Discussionmentioning

confidence: 99%

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Zhao

Yang

et al. 2019

European Journal of Radiology

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The aim of the present study was to develop and validate a radiomics-based nomogram for differentiation of preinvasive lesions from invasive lesions that appearing as ground-glass opacity nodules (GGNs) ≤10 mm (subcentimeter) in diameter at CT. A total of 542 consecutive patients with 626 pathologically confirmed pulmonary subcentimeter GGNs were retrospectively studied from October 2011 to September 2017. All the GGNs were divided into a training set (n = 334) and a validation set (n = 292). Researchers extracted 475 radiomics features from the plain CT images; a radiomics signature was constructed with the least absolute shrinkage and selection operator (LASSO) based on multivariable regression in the training set. Based on the multivariable logistic regression model, a radiomics nomogram was developed in the training set. The performance of the nomogram was evaluated with respect to its calibration, discrimination, and clinical-utility and this was assessed in the validation set. The constructed radiomics signature, which consisted of 15 radiomics features, was significantly associated with the invasiveness of subcentimeter GGNs (P < 0.0001 for both training set and validation set). To build the nomogram model, radiomics signature and mean CT value were used. The nomogram model demonstrated good discrimination and calibration in both training set (C-index, 0.716 [95% CI, 0.632 to 0.801]) and validation set (C-index, 0.707 [95% CI, 0.625 to 0.788]). Decision curve analysis (DCA) indicated that radiomics-based nomogram was clinically useful. A radiomics-based nomogram that incorporates both radiomics signature and mean CT value is constructed in the study, which can be conveniently used to facilitate the preoperative individualized prediction of the invasiveness in patients with subcentimeter GGNs.

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Section: Discussionmentioning

confidence: 99%

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Zhao

Yang

et al. 2019

European Journal of Radiology

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“…1 Despite therapeutic advances in recent years, the high mortality of patients with NSCLC has not been substantially reduced, largely because of the potential of invasion, metastasis, and frequent recurrence. 2 Another important reason for poor outcomes is that NSCLC is often only detected after it has spread beyond the primary site. If the cancer is diagnosed at an early stage, the five-year survival rate increases to about 50%.…”

Section: Introductionmentioning

confidence: 99%

Loss expression of micro ribonucleic acid (miRNA)‐200c induces adverse post‐surgical prognosis of advanced stage non‐small cell lung carcinoma and its potential relationship with ET_AR messenger RNA

Zhao

Wang

et al. 2015

Thoracic Cancer

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BackgroundNon-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. As micro ribonucleic acid (miRNA)-200 and ETAR may play an essential role in the process of epithelial to mesenchymal transition (EMT) simultaneously, the purpose of this study was to detect the expression of miRNA-200c and ETAR messenger (m)RNA and assess their prognostic significance in early stage NSCLC.MethodsOur study included 78 advanced stage (IIB, IIIA, IIIB) NSCLC patients. All patients were smokers. Using quantitative reverse transcriptase polymerase chain reaction analysis, we detected the expression of miRNA-200c and ETAR mRNA and assessed their correlation by χ2 test. Time to progression was used as the recurrent index and was assessed by univariate and multivariate analysis in the Cox hazard model.ResultsBoth miRNA-200c and ETAR mRNA expression are associated with N stage and tumor node metastasis (TNM) stage in a series of advanced NSCLC patients. Among N stage and TNM stage patients, significant differences were found in IIB (P = 0.0126), IIIB (P = 0.0107) and N0 (P = 0.0023) and in N1 + N2 groups (P = 0.0133). Using both univariate and multivariate survival analyses, we found that miRNA-200c (hazard ratio [HR] = 0.352, 95% confidence interval [CI]: 0.187–0.662) and ETAR mRNA (HR = 2.500 95% CI: 1.345–4.647) were independent prognostic factors, independent of TNM stage (HR = 2.414, 95% CI: 1.600–3.642) and differentiation (HR = 1.530, 95% CI: 1.050–2230).Conclusions miRNA-200c induces an expedient surgical survival, whereas ETAR mRNA has the reverse prognosis in advanced stage NSCLC patients. A potential relationship exists in that miRNA-200c targets ETAR mRNA during EMT.

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“…Behera et al pooled 19 studies on AIS and MIA conducted between 2011 and 2015 and analyzed survival rates. 7 , 8 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 They revealed that the 5‐year disease‐free survival rates for AIS and MIA were both 100% and that the 5‐year overall survival rates for AIS and MIA were 100 and 98.5%, respectively; 18 however, the difference was not statistically significant. Thus, they recommended further research to address questions relating to the value of the new classification system.…”

Section: Discussionmentioning

confidence: 99%

“…The significance of staging a lung ADC tumor as pTis, pT1a(mi), and pT1a has been previously challenged. Behera et al pooled 19 studies on AIS and MIA conducted between 2011 and 2015 and analyzed survival rates 7,8,18–35 . They revealed that the 5‐year disease‐free survival rates for AIS and MIA were both 100% and that the 5‐year overall survival rates for AIS and MIA were 100 and 98.5%, respectively; 18 however, the difference was not statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma

et al. 2023

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Background The eighth edition of the American Joint Committee on Cancer (AJCC) staging system for lung cancer adopts new criteria for tumor size, and for determining pTis, pT1a(mi), and pT1a. The latter is based on the size of stromal invasion. It is quite challenging for lung pathologists. Methods All patients who had undergone surgical resection for pulmonary adenocarcinoma (ADC) at Chung Shan Medical University Hospital between January 2014 and April 2018 were reviewed, and restaged according to the eighth AJCC staging system. The clinical characteristics and survival of patients with tumor stage 0 (pTis), I or II were analyzed. Results In total, 376 patients were analyzed. None of the pTis, pT1a(mi), or pT1a tumors recurred during the follow‐up period up to 5 years, but pT1b, pT1c, pT2a, and pT2b tumors all had a few tumor recurrences ( p < 0.0001). In addition, 95.2%, 100%, and 77.5% of pTis, pT1a(mi), and pT1a tumors, respectively, had tumor sizes ≤1.0 cm by gross examination. All pTis, pT1a(mi), and pT1a tumors exhibited only lepidic, acinar, or papillary patterns histologically. Conclusions This study demonstrated excellent survival for lung ADC patients with pTis, pT1a(mi), and pT1a tumors when completely excised. To reduce the inconsistencies between pathologists, staging lung ADC with tumors of ≤1 cm in size grossly as pTis, pT1a(mi), or pT1a may not be necessary when the tumors exhibit only lepidic, acinar, or papillary histological patterns. A larger cohort study with sufficient follow‐up data is necessary to support this proposal.

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Clinicopathological characteristics of subcentimeter adenocarcinomas of the lung

Cited by 13 publications

References 24 publications

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Loss expression of micro ribonucleic acid (miRNA)‐200c induces adverse post‐surgical prognosis of advanced stage non‐small cell lung carcinoma and its potential relationship with ET_AR messenger RNA

Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma

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Clinicopathological characteristics of subcentimeter adenocarcinomas of the lung

Cited by 13 publications

References 24 publications

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Development and validation of a radiomics nomogram for identifying invasiveness of pulmonary adenocarcinomas appearing as subcentimeter ground-glass opacity nodules

Loss expression of micro ribonucleic acid (miRNA)‐200c induces adverse post‐surgical prognosis of advanced stage non‐small cell lung carcinoma and its potential relationship with ETAR messenger RNA

Challenges of the eighth edition of the American Joint Committee on Cancer staging system for pathologists focusing on early stage lung adenocarcinoma

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Loss expression of micro ribonucleic acid (miRNA)‐200c induces adverse post‐surgical prognosis of advanced stage non‐small cell lung carcinoma and its potential relationship with ET_AR messenger RNA