Clinicopathological Characteristics, Treatment, and Prognosis of Rarely Primary Epididymal Adenocarcinoma: A Review and Update

Zou, Zhen; Yu, Xiao; Liu, Zhihong; Zhang, Ruochen; Liang, Jiayu; Tang, Yefeng; Lu, Yiping

doi:10.1155/2017/4126740

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…For confirming the metastatic nature of a carcinoma in the epididymis, history of primary tumor, comparison of the histologic features of the primary and metastatic cancer have been very important and immunohistochemistry has been reported to help confirming the primary origin, such as PSA for prostatic cancer. However, no spe-cific marker has been reported in primary cancers of epididymis (15).…”

Section: Discussionmentioning

confidence: 99%

Epididymal Metastasis of Cholangiocarcinoma, an Extremely Rare Event: A Case Report and Review of the Literature

et al. 2019

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Metastatic carcinoma to the epididymis is a very rare occurrence. Since the last 20 years, there have been only 13 cases reported in the English literature so far. The majority of the previous case reports presented with scrotal swelling and the most common primary carcinoma metastatic to epididymis has been prostatic adenocarcinoma. The size of the tumors has been small and below 5-cm. The age range has been 50 to 77 years. Herein we report the largest reported metastatic carcinoma to the epididymis (6-cm) in the youngest patient reported (36-year-old). Also, the second case of metastatic cholangiocarcinoma to the epididymis.

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Section: Discussionmentioning

confidence: 99%

Epididymal Metastasis of Cholangiocarcinoma, an Extremely Rare Event: A Case Report and Review of the Literature

et al. 2019

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“…Consequently, treatment of epididymal neoplasms has not been standardized, and is limited to en bloc excision via radical orchiectomy or epididymectomy once intraoperative findings suggest malignancy [ 6 ]. If there are indications of metastasis, it is further recommended to undergo retroperitoneal lymph node dissection, although this data is based on very limited series [ 7 ]. Defined by case reports and literature reviews, the current scope of knowledge on epididymal tumors is narrow [ 2 , 8 – 14 ].…”

Section: Introductionmentioning

confidence: 99%

Contemporary analysis of epididymal tumors using a national database

Bhatt

Davaro

Wong

et al. 2021

Cent european J Urol

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Introduction Epididymal tumors are rare malignancies with sparse research available to guide recommendations. We sought to characterize malignant epididymal tumors in the United States using population level data. Material and methods The Surveillance, Epidemiology, and End-Results database was queried for patients diagnosed with malignant epididymal tumors between 1975–2016. International classification of disease for oncology code C63.0 was used to identify population with disease of interest. Primary objective was to characterize patient demographics, disease characteristics, and management. Secondary objectives included overall and cancer-specific survival (CSS) utilizing Kaplan-Meier (KM) analysis. Results A total of 66 cases of malignant epididymal tumors were identified during the study period. The cohort was largely white (84.8%), with a mean age of diagnosis of 46.9 years old. The predominant histology consisted of rhabdomyosarcoma 26%, leiomyosarcoma 23%, liposarcoma 17%, adenocarcinoma 9%, and malignant fibrous histiocytoma 5%. During histopathological assessment, 21.1% of tumors were classified as high-grade while 71.2% exhibited sarcomatoid elements. Majority of patients presented with localized disease (68.2%), whereas regional (18.2%) and distant (13.2%) disease was less frequently discovered. All patients were diagnosed by surgical therapy consisting of radical epididymectomy (39.4%), partial epididymectomy (27.3%) or ‘unknown surgery’ (33.3%). Meanwhile, 15.2% and 34.8% received radiation and chemotherapy, respectively. KM analysis revealed an 84.9% CSS at 5-years. Over 60% of documented cases have arisen since 2000, with 3.0% of the cohort diagnosed in 2016, increased from 1.5% of the diagnoses in 1975. Conclusions Malignant epididymal tumors are exceedingly rare and typically present with localized disease. Surgical excision is associated with an estimated 85% CSS at 5-years.

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Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution

et al. 2020

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Clinicopathological Characteristics, Treatment, and Prognosis of Rarely Primary Epididymal Adenocarcinoma: A Review and Update

Cited by 6 publications

References 21 publications

Epididymal Metastasis of Cholangiocarcinoma, an Extremely Rare Event: A Case Report and Review of the Literature

Epididymal Metastasis of Cholangiocarcinoma, an Extremely Rare Event: A Case Report and Review of the Literature

Contemporary analysis of epididymal tumors using a national database

Appendageal tumors and tumor-like lesions of the testis and paratestis: a 32-year experience at a single institution

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