Clinicopathological characterization of follicular helper T-cell-derived peripheral T-cell lymphoma involving Waldeyer’s ring

Wang, Jianchao; Tang, Wangyang; Zhang, Wenfang; Wang, Jie-Song; Chen, Fangfang; Zhong, Lintao; Chen, Yanping; Chen, Gang

doi:10.1007/s00428-021-03071-z

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…Compared with nTFHL-AI, nTFHL-NOS exhibited lower expression levels of TFH signal, which is consistent with findings from previous studies ( 15 , 16 , 27 ). Additionally, further observation revealed that nTFHL-NOS patients had a lower median Ki67 index, indicating decreased proliferative activity.…”

Section: Discussionsupporting

confidence: 92%

Clinicopathologic analysis of nodal T-follicular helper cell lymphomas, a multicenter retrospective study from China

Ma,

Li,

Zuo

et al. 2024

Front. Immunol.

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BackgroundNodal T-follicular helper cell lymphomas (nTFHLs) represent a new family of peripheral T-cell lymphomas (PTCLs), and comparative studies of their constituents are rare.MethodsThis study retrospectively enrolled 10 patients with nTFHL-F and 30 patients with nTFHL-NOS diagnosed between December 2017 and October 2023 at six large comprehensive tertiary hospitals; 188 patients with nTFHL-AI were diagnosed during the same period at the First Affiliated Hospital of Zhengzhou University for comparison.ResultsCompared with nTFHL-AI, nTFHL-NOS patients exhibited better clinical manifestations, lower TFH expression levels, and a lower Ki-67 index. However, no differences in clinicopathological features were observed between nTFHL-F and nTFHL-AI patients as well as nTFHL-NOS patients. According to the survival analysis, the median OS for patients with nTFHL-NOS, nTFHL-AI, and nTFHL-F were 14.2 months, 10 months, and 5 months, respectively, whereas the median TTP were 14 months, 5 months, and 3 months, respectively. Statistical analysis revealed differences in TTP among the three subtypes(P=0.0173). Among the population of patients receiving CHOP-like induction therapy, there were significant differences in the OS and TTP among the nTFHL-NOS, nTFHL-AI, and nTFHL-F patients (P=0.0134, P=0.0205). Both the GDPT and C-PET regimens significantly improved the ORR, OS, and PFS in nTFHL patients.ConclusionThere are significant differences in the clinical manifestations, pathology, and survival outcomes among the three subtypes of nTFHLs. However, further research with a larger sample size, and involving clinical pathology and molecular genetics is needed to determine the distinctive biological characteristics of these tumors.

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Section: Discussionsupporting

confidence: 92%

Clinicopathologic analysis of nodal T-follicular helper cell lymphomas, a multicenter retrospective study from China

Ma,

Li,

Zuo

et al. 2024

Front. Immunol.

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“…DNA from 21 cases, including 14 previously reported cases,9 met the quantity and quality standards for the targeted next-generation sequencing analysis, using a custom lymphoma panel covering 112 lymphoma-related genes. The next-generation sequencing library preparation, capture-based targeted DNA sequencing, and sequencing data analysis were performed as per the methods described in a previous study 10…”

Section: Methodsmentioning

confidence: 99%

“…The next-generation sequencing library preparation, capture-based targeted DNA sequencing, and sequencing data analysis were performed as per the methods described in a previous study. 10…”

Section: Targeted Next-generation Sequencing Analysismentioning

confidence: 99%

JAK/STAT3 Signaling Activation Related to Distinct Clinicopathologic Features in Systemic ALK− Anaplastic Large Cell Lymphomas

Wang

Zhong

Lin

et al. 2022

American Journal of Surgical Pathology

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Systemic anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a group of heterogenous CD30 + T-cell non-Hodgkin lymphomas. Previous studies have highlighted the importance of JAK/STAT3 signaling activation in the molecular pathogenesis of ALK − ALCLs. In the present study, we aimed to establish a potential relationship between JAK/STAT3 signaling activation and clinicopathologic features in ALK − ALCLs, and further recognize the heterogenous nature of these neoplasms. Immunohistochemistry staining of the phosphorylated-STAT3 (p-STAT3) and dualspecificity protein phosphatase 22 (DUSP22) gene rearrangement analysis were performed. Forty-five cases of ALK − ALCL were divided into 3 groups, including 9 DUSP22-rearranged ALCLs, 21 p-STAT3 + double-negative (DN) ALCLs (both ALK and DUSP22 rearrangement negative), and 15 p-STAT3 − DN-ALCLs. Morphologically, p-STAT3 + DN-ALCLs exhibited sheet-like neoplastic cells and sometimes showed large pleomorphic cells scattered in a lymphocyte-rich background more frequently than those in other ALK − ALCLs subtypes. Phenotypically, the p-STAT3 + DN-ALCLs frequently expressed cytotoxic molecules, epithelial membrane antigen, and programmed death-ligand 1, whereas CD3 and CD5 expression was not observed. Clinically, patients with p-STAT3 + DN-ALCLs had a better prognosis than those with p-STAT3 − DN-ALCLs. These observations suggest that p-STAT3 + DN-ALCLs represent a distinct subtype of ALK − ALCLs. Identifying ALK − ALCL subtypes by using p-STAT3 staining and DUSP22 rearrangement is a promising approach that may contribute to risk stratification and better treatment decisions in the future clinical practice.

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“…There are anecdotal reports of patients presenting with a smoldering course with waxing and waning lymphadenopathy ( 37 , 38 ). While AITL is a systemic disease, rare cases of AITL and PTCL with TFH phenotype with localized disease and more indolent behavior have been reported, for example cases localized to the Waldeyer’s ring at presentation ( 39 ).…”

Section: Nodal T-follicular Helper Cell Lymphomasmentioning

confidence: 99%

Pathologic and molecular insights in nodal T-follicular helper cell lymphomas

2023

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T-follicular helper (TFH) cells are one of the T-cell subsets with a critical role in the regulation of germinal center (GC) reactions. TFH cells contribute to the positive selection of GC B-cells and promote plasma cell differentiation and antibody production. TFH cells express a unique phenotype characterized by PD-1hi, ICOShi, CD40Lhi, CD95hi, CTLAhi, CCR7lo, and CXCR5hi. Three main subtypes of nodal TFH lymphomas have been described: 1) angioimmunoblastic-type, 2) follicular-type, and 3) not otherwise specified (NOS). The diagnosis of these neoplasms can be challenging, and it is rendered based on a combination of clinical, laboratory, histopathologic, immunophenotypic, and molecular findings. The markers most frequently used to identify a TFH immunophenotype in paraffin-embedded tissue sections include PD-1, CXCL13, CXCR5, ICOS, BCL6, and CD10. These neoplasms feature a characteristic and similar, but not identical, mutational landscape with mutations in epigenetic modifiers (TET2, DNMT3A, IDH2), RHOA, and T-cell receptor signaling genes. Here, we briefly review the biology of TFH cells and present a summary of the current pathologic, molecular, and genetic features of nodal lymphomas. We want to highlight the importance of performing a consistent panel of TFH immunostains and mutational studies in TCLs to identify TFH lymphomas.

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Clinicopathological characterization of follicular helper T-cell-derived peripheral T-cell lymphoma involving Waldeyer’s ring

Cited by 4 publications

References 22 publications

Clinicopathologic analysis of nodal T-follicular helper cell lymphomas, a multicenter retrospective study from China

Clinicopathologic analysis of nodal T-follicular helper cell lymphomas, a multicenter retrospective study from China

JAK/STAT3 Signaling Activation Related to Distinct Clinicopathologic Features in Systemic ALK− Anaplastic Large Cell Lymphomas

Pathologic and molecular insights in nodal T-follicular helper cell lymphomas

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