Clinicopathological features and CD57 expression in renal cell carcinoma in acquired cystic disease of the kidneys: with special emphasis on a relation to the duration of haemodialysis, the degree of calcium oxalate deposition, histological type, and possible tumorigenesis

Enoki, Yuichiro; Katoh, Genichi; Okabe, Hidetoshi; Yanagisawa, Akio

doi:10.1111/j.1365-2559.2010.03480.x

Cited by 32 publications

(35 citation statements)

References 27 publications

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“…20,21 In some recent publications, a long duration of dialysis (>10 y) has had a stronger association with ACD-RCC compared with other subtypes of RCC arising in this setting, [22][23][24] although such an association was not identified in another large series. 5,[20][21][22]24,25 Most tumor cells have abundant granular eosinophilic cytoplasm, with round to oval nuclei showing vesicular chromatin and prominent nucleoli. The noncystic tumors are well circumscribed and may be surrounded by a thick fibrous capsule showing dystrophic calcification.…”

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 94%

“…20 The tumors often appear as nodules arising from cyst walls, occasionally completely filling these cysts, or as solid masses separate from the cysts. One characteristic feature is the presence of intracellular and/or intercellular microscopic lumina (holes), imparting a cribriform/sieve-like appearance 5,20,22,24,25 (Fig. Cut surfaces are tan to yellow, and hemorrhage and necrotic/friable areas are commonplace.…”

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 99%

See 1 more Smart Citation

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley¹,

Delahunt²,

Eble³

et al. 2013

American Journal of Surgical Pathology

946

727

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The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

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Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 94%

Section: Proposed New Epithelial Neoplasms Tubulocystic Renal Cell Camentioning

confidence: 99%

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Srigley¹,

Delahunt²,

Eble³

et al. 2013

American Journal of Surgical Pathology

946

727

View full text Add to dashboard Cite

show abstract

“…The accumulation of small amounts of calcium oxalate crystals in the absence of aberrant oxalate metabolism has been termed dystrophic oxalosis [28]. This has been reported in a number of tissues including arterial atherosclerotic plaques, myocardium, lymph nodes, testis, thyroid, breast, ocular tissues, and kidneys with acquired cystic disease [28, 29]. In the study of calcium oxalate deposits in coronary artery atherosclerotic plaques, the 4 patients all had chronic diseases that can increase oxidative stress levels, including AIDS, hepatitis C, sepsis, ischemic heart disease, and cancer [28].…”

Section: Calcium Oxalate In Tissuesmentioning

confidence: 99%

“…For example, end-stage renal disease is associated with oxidative stress. Enoki et al reported that oxalate deposition in the kidneys of patients with acquired cystic disease was positively correlated with the number of months being on dialysis [29]. …”

Section: Calcium Oxalate In Tissuesmentioning

confidence: 99%

Glyoxal Formation and Its Role in Endogenous Oxalate Synthesis

Lange

Wood

Knight

et al. 2012

Advances in Urology

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Calcium oxalate kidney stones are a common condition affecting many people in the United States. The concentration of oxalate in urine is a major risk factor for stone formation. There is evidence that glyoxal metabolism may be an important contributor to urinary oxalate excretion. Endogenous sources of glyoxal include the catabolism of carbohydrates, proteins, and fats. Here, we review all the known sources of glyoxal as well as its relationship to oxalate synthesis and crystal formation.

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“…La plupart du temps il s'agit d'une tumeur de découverte fortuite. Selon certaines publications, il existerait un rapport entre la durée de la dialyse (> 10 ans) et le développement de cette tumeur mais les résultats sont encore contradictoires [7,8]. Macroscopiquement, il s'agit de nodules bien encapsulés se développant au sein des kystes.…”

Section: Carcinome Rénal Associé à Une Maladie Rénale Kystique Acquiseunclassified

Les tumeurs rénales : recommandations de la conférence de consensus de l’International Society of Urologic Pathology (ISUP) 2012

Rioux‐Leclercq

Algaba

Amin

et al. 2014

Annales de Pathologie

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Clinicopathological features and CD57 expression in renal cell carcinoma in acquired cystic disease of the kidneys: with special emphasis on a relation to the duration of haemodialysis, the degree of calcium oxalate deposition, histological type, and possible tumorigenesis

Abstract: ACDK-RCCs reveal characteristics of Henle's loop, which may be related to their peculiar pathological features, including intratumoral oxalate deposition and cyst and AC formation.

Cited by 32 publications

References 27 publications

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia

Glyoxal Formation and Its Role in Endogenous Oxalate Synthesis

Les tumeurs rénales : recommandations de la conférence de consensus de l’International Society of Urologic Pathology (ISUP) 2012

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