Clinicopathological features and maternal and foetal management of pregnancy‑complicating Krukenberg tumours

Abstract

Krukenberg tumours are not uncommon, but pregnancy-complicating Krukenberg tumours are rare. To identify management strategies of pregnancies with Krukenberg tumours, the medical records of patients treated at Peking Union Medical College Hospital over the past 20 years were collected and analysed. Four patients were enrolled. The primary tumour sites were the stomach and colorectal region. Three patients presented with obvious and severe gastrointestinal symptoms at 11-18 weeks of gestation, and their symptoms gradually developed into physiological signs associated with malignancy. Three patients underwent termination of pregnancy via induced delivery and gestational hysterectomy. One patient underwent caesarean section at 31 weeks of gestation. Two patients underwent palliative surgery due to extensive lesions. The other two patients with metastatic lesions confined to the ovaries and liver, underwent satisfactory cytoreductive surgery and anti-tumour treatments postoperatively. Pregnant women who exhibit new gastrointestinal symptoms or aggravation of previous gastrointestinal symptoms after the end of the first trimester should be carefully examined for digestive system diseases. If ovarian metastasis is highly suspected, the pregnancy should be terminated as early as possible. Materials and methods From January 1, 1999 to January 1, 2019, four pregnant women of Chinese Han nationality with ovarian metastasis who were hospitalized and had complete clinical records at the Department of Obstetrics and Gynaecology, PUMCH, were enrolled into the present study. Data regarding the general condition, symptoms, preoperative examinations and diagnosis of each patient, as well as data regarding foetal treatment and outcome, surgery, postoperative pathology and prognosis were collected and analysed. SPSS Statistics (version 25.0) was used to calculate our descriptive statistics. The median age of the four patients was 31.5 years. The median gestational age on admission was 21 weeks and 5 days (Table I). Two patients had no routine physical examination or obstetrical care; the other two patients were routinely examined

Case Report: Gastric Cancer Combined With Bilateral Ovarian Metastasis In Pregnancy

“…Follow-up found that the newborn was alive and the growth and development were normal. The treatment of ovarian malignant tumors requires a comprehensive assessment of the tumor (degree of malignancy), pregnant women and their families (the physical condition of the pregnant women, the expectation of the pregnant women and their family members for the fetus), the fetus (gestational age, survival ability), the hospital's critically ill newborns and critically ill pregnant women's ability and other factors [11,12].…”

Krukenberg tumour in a patient with secondary infertility – case report

“…Based on 48 studies from an electronic database of 3,025 women with Krukenberg tumours, Lionetti et al reported that 39.7% of patients were ≥50 years of age (11) . Rare cases of Krukenberg tumours in pregnant women have also been described (12,13) . Bilateral and synchronous Krukenberg tumours account for about 60-80% and over 63% of cases, respectively.…”