Clinicopathological Features and Prognosis of Gastric Neuroendocrine Neoplasms

Abstract

<jats:title>Abstract</jats:title> <jats:p><jats:bold>Purpose:</jats:bold> We performed a retrospective study to investigate the relationship between clinicopathological features and prognosis of G-NEN.<jats:bold>Methods:</jats:bold> Clinicopathological features and follow-up data of 67 patients with G-NEN treated at Shandong Provincial Hospital affiliated of Shandong University were analyzed retrospectively. <jats:bold>Results:</jats:bold> This whole cohort included 53 males and 14 females, with a mean age of 59.37±9.80 years. The clinical symptoms and the primary tumor site were not specific. Neuroendocrine tumor, neuroendocrine carcinoma, and mixed neuroendocrine–non‐neuroendocrine neoplasm accounted for 14.93%, 59.70%, and 25.37%, respectively. TNM stages Ⅰ-Ⅳ: 6, 6, 49, 4, respectively. All patients underwent surgically treated. Forty-five patients underwent laparoscopic surgery, and twenty-two patients received an open approach. The median survival time was 36 months in all patients. The overall survival rate for the entire cohort was 68.1 %, 44.7 %, and 34.5% at 1, 3, and 5 years, respectively. Logistic regression analysis revealed that the invasive depth of tumors was predictors for metastasis. The univariate analysis confirmed that smoking, T stage, distant metastasis, and surgical method were related to survival. COX regression analysis showed that the T stage (HR=4.817, 95%CI: 1.021-22.729, P=0.047) was an independent risk factor for evaluating the prognosis of patients with G-NEN.<jats:bold>Conclusions:</jats:bold> G-NEN is a kind of rare tumors that can occur at any part of the stomach. The clinical features are not specific. The tumor invasive depth related to tumor metastasis. The prognosis is associated with smoking, T stage, distant metastasis, and surgical method. Of them, T stage is an independent prognostic factor for G-NEN patients. But larger studies are needed in the future.</jats:p>

Mixed adenoneuroendocrine carcinoma of the extrahepatic bile duct: a case report

“…1 Since the concept of MANEC was introduced in 2010, 1 cases of MANEC have been continuously reported. MANECs usually develop in the colon or stomach [2][3][4] ; those in the bile ducts are exceptionally rare. In one report, MANEC originating from the extrahepatic bile duct was poorly differentiated, malignant, and invasive.…”