Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Li, Zhiyu; Wu, Xiaolong; Bi, Xinyu; Zhang, Yefan; Huang, Zhen; Lu, Haizhen; Zhao, Hong; Zhao, Jianjun; Zhou, Jianguo; Li, Muxing; Ying, Jianming; Cai, Jianqiang

doi:10.21147/j.issn.1000-9604.2018.03.08

Cited by 32 publications

(42 citation statements)

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“…Patients had larger tumor size (>96 mm) in the present study in comparison with the previous report representing a tumor diameter of 50 mm, which was correlated with more aggressive PCCCL, respectively [22]. Of patients with PCCCL in the cohort with recorded pathological differentiation grade, tumor with moderate differentiation occupied a maximal proportion (27.0%, 113 of 419), which corresponded to the description in additional studies [4,16,20]. Of those who have undergone lymph node examinations, lymph node metastases were not usual, representing merely 4.5%, which was also reflected in the TNM pathologic stage, with more likely to be stage I or II, indicating the relatively indolent biology of PCCCL.…”

Section: Discussionsupporting

confidence: 87%

“…Clear cell carcinoma prevailingly occurs in the ovary [1] and kidney [2], however, it has been rarely reported in additional locations like the lungs [3], liver [4]. Primary clear cell carcinoma of the liver (PCCCL) is an uncommon pathological subtype of primary hepatocellular carcinoma (HCC), with insufficient comprehension of its clinicopathological characteristics and prognostic factors on account of merely few case reports or clinical cohort studies from small, single institution.…”

Section: Introductionmentioning

confidence: 99%

“…It is pathologically characterized by prominent cytoplasmic accumulation of abundant glycogen or/and lipid that are dissolved during hematoxylin and eosin staining, thereby merely showing a clear cytoplasm [6]. PCCCL can develop at any age, with a peak incidence in male patients aging from 50 to 60 years old [4].…”

Section: Introductionmentioning

confidence: 99%

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Development and Identification of a Nomogram Prognostic Model for Patients with Primary Clear Cell Carcinoma of the Liver

et al. 2020

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Background: Primary clear cell carcinoma of the liver (PCCCL) is an infrequent variant of primary hepatocellular carcinoma (HCC), we retrospectively performed a large population-based cohort study to elucidate the relationships between demographic, carcinoma-and therapy-specific variables and overall survival (OS). Material/Methods: The Surveillance, Epidemiology and End Results (SEER) database was queried to extract data on 419 patients with pathologically confirmed PCCCL from 1988 to 2015. A nomogram with good accuracy was formulated to predict long-term survival of PCCCL patients. Results: The OS for PCCCL patients was 25.6 months (95% confidence interval [CI]: 22.2-29 months), the overall 1-year, 3-year, and 5-year survival rates were 59.5%, 39.3%, and 29.9%, respectively. Log-rank analysis revealed that there was no statistically significant discrepancy in clinical outcome between PCCCL and common-type HCC after propensity-matched analysis. Multivariate Cox analysis confirmed that larger lesions (>96 mm), distant metastases and elevated alpha-fetoprotein (AFP) levels were independent prognostic factors for undesirable outcome. Conversely, surgery was an independent protective factor (hazard ratio [HR]=0.23, 95% CI 0.17-0.31), which significantly boosted OS by virtually 35 months (47.3 months versus 12.7 months, P<0.001). Radiotherapy or chemotherapy was not associated with OS for PCCCL patients (both P>0.05). The nomogram incorporated 4 independent prognostic factors and its concordance index for predicting survival was 0.761. Conclusions: The prognosis of PCCCL resembled that of common-type HCC. Larger lesions, distant metastases, and enhanced AFP levels were associated with unsatisfactory prognosis. Surgery fulfill favorable prognosis while radiotherapy or chemotherapy exerted no significant effects on survival.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Development and Identification of a Nomogram Prognostic Model for Patients with Primary Clear Cell Carcinoma of the Liver

et al. 2020

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“…In this study, the median OS following surgical resection for iCCA patients (n = 200) was 16.7 months, similar to that in other reports . After controlling for many confounding factors affecting prognosis through PSM analysis, we reached a consistent conclusion with previous studies that the prognosis of iCCA‐SC is significantly worse than that of ordinary iCCA . For iCCA‐SC, there was a lack of characteristic imaging features from preoperative imaging findings, and there was no significant difference in preoperative serum CEA and CA125 levels between the two groups.…”

Section: Discussionsupporting

confidence: 88%

Clinical features of sarcomatoid change in patients with intrahepatic cholangiocarcinoma and prognosis after surgical liver resection: A Propensity Score Matching analysis

Wang

Kong

Shen

et al. 2019

Journal of Surgical Oncology

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Background: Intrahepatic cholangiocarcinoma with sarcomatoid change (iCCA-SC) is a rare histological subtype of iCCA, the clinical features and outcomes after surgical resection on the prognosis is still unknown. Methods:We retrospectively reviewed the clinical data of patients with histologically proven iCCA who underwent curative liver resection at our hospital between January 2008 and December 2018. Propensity score matching analysis was used to match patients with and without sarcomatoid change at a ratio of 1:4. The nomogram integrating all significant independent factors for overall survival (OS) and recurrence-free survival (RFS) was constructed to predict prognosis for iCCA. The predictive accuracy ability of the nomogram was determined by Harrell's index (C-index).Results: A total of 40 iCCA-SC and 160 ordinary iCCA patients were included in this study. RFS and OS in the iCCA-SC group were significantly lower than those in the ordinary iCCA group (P<.001 and P = .002, respectively). The calibration curve for the probability of survival showed good agreement between the nomogram prediction and actual observation. Conclusion:The histological sarcomatoid subtype is an independent predictor of tumor recurrence and shorter OS in iCCA patients. The nomogram we established could provide more accurate prognostic prediction for iCCA patients. K E Y W O R D S curative liver resection, intrahepatic cholangiocarcinoma, nomogram, propensity score matching analysis, sarcomatoid change SUPPORTING INFORMATION Additional supporting information may be found online in the Supporting Information section. How to cite this article: Wang T, Kong J, Yang X, Shen S, Zhang M, Wang W. Clinical features of sarcomatoid change in patients with intrahepatic cholangiocarcinoma and prognosis after surgical liver resection: A Propensity Score Matching analysis.

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“…Other subtypes including clear cell HCC, diffuse cirrhosis-like HCC, steatohepatitic HCC, transitional liver cell tumour, and College of American Pathologist (CAP) carcinoma are also recognised [13]. Several reports demonstrated that histomorphological variants of HCC are strong independent prognostic factors in the determination of treatment outcomes [14] [19]. Thus, some reports categorised these variants as low grade with favourable prognosis and high grade with worse outcomes respectively [13] [18].…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma in Benin City, Nigeria: A Twenty-Five (1987-2011) Year Retrospective Histopathological Study

G¹,

Olu-Eddo²,

Obaseki³

2019

Health

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Aim: To evaluate the demographic characteristics and histological variants of hepatocellular carcinoma (HCC) in Benin City. Methodology: The surgical daybooks of the Department of Anatomic Pathology, University of Benin Teaching Hospital were used for data collection. All the liver biopsies received in the period (1987-2011) under review diagnosed with HCC were analysed using SPSS version 16.0. Results: The male to female ratio was 2:1 and the peak age of incidence was in the 50-60 years age group. The mean ages were 44.24 ± 18.52 and 48.75 ± 12.92 and the age ranges were 1.5 to 82 years and 20 to 68 years for males and females respectively. The modal age was 60 years. Histological variants of hepatocellular carcinoma were the pseudoglandular/acinar pattern which accounted for 26 cases (44.07%), followed by the trabeculae pattern 17 cases (28.81%), the compact/solid variant 10 cases (16.95%) and the fibrolamellar pattern which was 6 cases (10.17%). Conclusion: Hepatocellular carcinoma has divergent demographic and histological characteristics which have clinical implications on the treatment outcomes; hence pathologists are encouraged to include the subtype in their reports for prognostication.

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Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma

Abstract: CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC. However, GCC, SC, and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis.

Cited by 32 publications

References 38 publications

Development and Identification of a Nomogram Prognostic Model for Patients with Primary Clear Cell Carcinoma of the Liver

Development and Identification of a Nomogram Prognostic Model for Patients with Primary Clear Cell Carcinoma of the Liver

Clinical features of sarcomatoid change in patients with intrahepatic cholangiocarcinoma and prognosis after surgical liver resection: A Propensity Score Matching analysis

Hepatocellular Carcinoma in Benin City, Nigeria: A Twenty-Five (1987-2011) Year Retrospective Histopathological Study

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