Clinicopathological Features and Survival Data of Localized Renal Masses in Young Adults

Abstract

Purpose:Renal tumors are rarely seen in young adults. In this study, was aimed to report the data of 18-40 years old patients with Renal Cell Carcinoma (RCC) whom we operated.Material and Method:We retrospectively reviewed the data of patients between the ages of 18 and 40 years old patients who have renal masses. All patients were evaluated with chest X-ray, Computed tomography (CT) and/or MRI. Radical or partial nephrectomy was performed for clinical localized masses with malignancy suspicion. Clinicopathological features and survival data of all the patients were recorded. In the follow-up protocol routine blood tests, chest X-ray and abdominal CT were used.Results:A total of 42 patients, [22 (52.4%) male and 20 (47.6%) female], with a mean age of 34.48 (range 18 to 40) were included in the study. Of these, 32 (%76) had RCC and 10 (24%) had benign pathologies. Female patients had more benign pathology (35% vs 13.6%). The most commonly subtype of RCC (n = 22% 69) was clear cell RCC (cRCC), while the most common benign mass was oncocytoma (n = 4% 40). At the mean follow-up period of 42.34 months, overall survival rate was found to be 93.8%.Conclusion:Young adults with localized renal mass have benign pathology in a considerable rate. All of the malign masses in this population have low Furhman grade (1 or 2).

Characteristics of the Patients Aged Less than 40 Years Operated for a Renal Mass

“…Furthermore, studies have shown that the probability of observing a benign lesion after histopathological evaluation in patients undergoing surgery for RCC is higher in women. Aslan et al reported 35% of young women having benign lesions after surgery, while this rate was only 13.6% in men, and this difference was statistically significant ( 26 ). Similarly, Yikilmaz et al also reported a significantly higher rate of benign lesions in young women ( 20 ).…”

“…In the general population, the detection rate of benign tumors in patients who had surgery for RCC was reported as being around 11-16% (23)(24)(25). Aslan et al conducted a study evaluating localized renal masses in patients aged <40 years, and reported that 24% of the patients were diagnosed with benign lesions (26). According to Yikilmaz et al, a benign lesion was discovered during pathological examination in 16% of the patients aged <50 years (20).…”

Carcinoma renal con cuadro clínico de infección urinaria recurrente en paciente joven

“…La edad de diagnóstico de la paciente fue 25 años, por debajo del promedio reportado en estudios previos 6,7 ; y en relación al género prevalente, respecto a los pacientes con CCR, los estudios difieren 16,17 . Entre los factores de riesgo más importantes para desarrollar CCR se encuentran el tabaquismo, la obesidad e hipertensión arterial entre otros 2,10 ; nuestra paciente no presentó dichos factores de riesgo para desarrollar neoplasia renal, ni tuvo familiares con alguna neoplasia en particular, considerándolo como un cáncer renal espontáneo siendo la translocación de genes más frecuente en jóvenes 8 .…”

“…Y el estudio de Jae Hee et al 12 evidenció que los pacientes adultos jovenes con neoplasia renal podrían tener un mejor pronóstico que los pacientes adultos mayores, al igual que Kang HW et al 6 quien mostró que la edad precoz al diagnóstico se relacionó con las características patológicas favorables. Asimismo, otro estudio evidenció que la tasa de supervivencia global y la tasa de supervivencia libre de enfermedad fue de 93,8% y 87,5% respectivamente en adultos jóvenes 16 . Por tanto, los hallazgos de estudios previos sugieren que la edad de diagnóstico es favorable para un mejor pronóstico y que no debe influir en el seguimiento y tratamiento del CCR.…”

Age and gender related differences in renal tumors in southern Iran; a cross-sectional study

“…In the present study, patients who underwent partial or radical nephrectomy due to renal mass over five years were evaluated and factors such as age, gender, type of operation, and pathological characteristics such as tumor The results indicated that female patients had almost twice as many benign masses as male patients and the rate of malignant tumors was higher in male patients and a significant relationship was found between them. In a study by Aslan et al in Turkey, although benign tumors were more common in women, no significant relationship was found between the two variables (5). In another comparison, the age and type of surgery were evaluated, which showed that the rate of partial nephrectomy decreased with age, while the rate of radical nephrectomy increased with age.…”