Clinicopathological features of anastomotic recurrence after an anterior resection for rectal cancer

Abstract

A difference was observed in the serum carcinoembryonic antigen, clinical symptom, and survival between patients with anastomotic and pelvic recurrence. Furthermore, according to these results, we should pay attention to these clinical features in the follow-up period.

Can Radiotherapy Alone Be Effective for Treating Anastomotic Recurrence of Rectal Cancer? When the Patient Decides?

“…True AR is relatively rare 15 and its actual incidence is not completely known as it is difficult to differentiate between a recurrence that originates from the suture line and a recurrence that develops outside the anastomosis and then spreads to the mucosa 6 involving the suture line, which should be considered as a ''local recurrence. ''…”

“…The literature reports an incidence of AR between 2.4% and 12% of all patients who underwent colorectal anastomosis 6,15,[17][18][19] and between 10% and 22% when considering the incidence of AR as percentage of local recurrences. 10,12,17 The pathogenesis of an AR after curative surgery for rectal cancer is not completely clear.…”

“…6,8,18,21 However, a true reduction of anastomotic implantations after washout has not been proved. 12,15,21 In consideration of this pathogenetic theory, the risk of developing AR is lower in the group of patients who received preoperative radiotherapy, 22 as it might reduce the number and the viability of exfoliated cells.…”

“…' 15 In the era of TME, there have been few reports focusing on AR after anterior resection of rectal cancer. 15 The authors report the case of a patient with AR treated only with radiotherapy.…”

Advantages of Laparoscopic Abdominoperineal Resection for Anastomotic Recurrence of Rectal Cancer

“…For local recurrence, the subsite is classified into presacral, postero-lateral, lateral, anterior, anastomotic or perineal (Kusters et al, 2009). Patients with anastomotic recurrence have a relatively better prognosis (Matsuda et al, 2010). Nowadays, treatment remains a difficult and challenging problem and no consensus exists as to an optimal treatment approach for local recurrence (Bedrosian et al, 2006).…”