Clinicopathological features of melanotic neuroectodermal tumor of infancy: Report of two cases

Higashi, Kenjiro; Ogawa, Takenori; Onuma, Masahiro; Usubuchi, Hajime; Imai, Yoshimichi; Takata, Iori; Hidaka, Hiroshi; Watanabe, Mika; Sasahara, Yoji; Koyama, Shihoko; Kure, Shigeo; Katori, Yukio

doi:10.1016/j.anl.2015.10.010

Cited by 23 publications

(40 citation statements)

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“…[17][18][19] Further, our literature review demonstrated that 92.5% of tumors affected the maxilla and 7.5% affected the mandible. 3,11,16,22 In our analysis, five cases reported regional lymph node metastasis and two were confirmed to be affected by the lesion. The melanotic epithelioid cells generally surround nests of small cells but may form solid and tubuloglandular structures.…”

Section: Discussionmentioning

confidence: 52%

“…In previous studies, researchers observed that MNTI of the jaw bones is found mainly in children below 1 year of age. 3,11,13 Mitoses and necrosis are generally absent but may be seen. Males were slightly more affected than females (ratio male:female 1.32:1).…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4] This lesion was first described by Krompecher in 1918. [1][2][3][4] This lesion was first described by Krompecher in 1918.…”

Section: Introductionmentioning

confidence: 96%

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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The aim of the present study was to integrate the available data published on melanotic neuroectodermal tumor of infancy (MNTI) of the jaw bones. An electronic search was undertaken in April 2018. Hundred forty‐seven publications and 371 patients were included. The lesion was more prevalent in males and in the second to sixth months of life. The lesions mostly presented as a rapidly growing bluish swelling and the most commonly involved was the anterior maxilla. The mean follow‐up was 51.1 months (range 1‐408 months). Age (P ≤ .0001), location (P = .007), occurrence of lymph node metastasis (P ≤ .0001), treatment (P = .001), recurrence (P ≤ .0001), and distant metastasis (P = .0001) were independently associated with survival. Recurrence was significantly correlated with age (P = .0001), distant metastasis (P = .0001), and treatment (P = .0001). Patients older than 12 months, with lesions in the mandible, positive regional lymph node metastasis, treated with chemotherapy, recurrence, or distant metastasis presented the worst prognosis.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

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Melanotic neuroectodermal tumor of infancy of the jaw bones: Update on the factors influencing survival and recurrence

et al. 2018

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“…Treatment involving chemotherapy and radiotherapy has been described as controversial [4]. Recurrence is estimated at 15% with possible causes being incomplete removal, seeding during surgery, or multicentricity of the primary tumor [1].…”

Section: Discussionmentioning

confidence: 99%

“…Although a benign lesion, it can cause major deformities due to its rapid growth. The reported rate of recurrence is approximately 15%, while the rate of malignant transformation is 6.8% [1,2,4]. We present a rare case of a 6-month-old infant with MNTI of the upper arm.…”

Section: Introductionmentioning

confidence: 90%

Melanotic Neuroectodermal Tumor of Infancy of the Upper Arm

Kirigin¹,

Džombeta²,

Seiwerth³

et al. 2017

Med Princ Pract

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Objective: To present a case of a 6-month-old infant with melanotic neuroectodermal tumor of infancy (MNTI) in the upper arm. Clinical Presentation and Intervention: A 6-month-old female presented with a well-circumscribed lesion of the upper arm at the Children's Hospital Zagreb. A biopsy was performed and microscopy revealed 2 cell populations consisting of small neuroblastic cells and larger melanin-containing epithelial cells. An excisional biopsy performed 1 month later confirmed the initial diagnosis of MNTI, but the tumor had increased in size since the initial biopsy. After complete surgical excision the patient recovered well with no recurrence. Conclusion: The MNTI located in the upper arm was diagnosed on first biopsy and surgically excised completely. The patient recovered without recurrence in a follow-up of 2.5 years.

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