Clinicopathological features of nodular gastritis in three classes of age

Kako, Satoko; Iwaya, Yugo; Nagaya, Tadanobu; Hara, Daichi; Okamura, Takuma; Iwaya, Mai; Kurasawa, Shingo; Kato, Sawako; Nakayama, Yoshiko; Akamatsu, Taiji; Umemura, Takeji

doi:10.1111/hel.12845

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…Although endoscopic examination after eradication therapy is considered beneficial, regular endoscopic follow-up for all young patients treated with eradication is challenging. We have reported that the degree of histological inflammation in the gastric body varies among NG cases; not all NG has the same risk for diffuse-type gastric cancer, and patients with more severe inflammation in the gastric body may be considered high risk for gastric cancer [20]. In the present case, moderate inflammatory cell infiltration in the gastric body was observed in histological evaluations before eradication.…”

Section: Discussionmentioning

confidence: 43%

Gastric Cancer After Helicobacter pylori Eradication for Nodular Gastritis in an Adolescent

Okmaura¹,

Iwaya²,

Iwaya³

et al. 2022

Cureus

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A 16-year-old girl underwent esophagogastroduodenoscopy (EGD) after the detection of Helicobacter pylori (H. pylori) antibodies in her urine during a school health screening, which revealed nodular gastritis (NG). She was diagnosed as having H. pylori infection histologically and by biopsy culture specimens and soon commenced eradication therapy. Eight weeks later, eradication was confirmed by a urea breath test. At the age of 19, however, she was referred to our hospital with epigastralgia and lower back pain. EGD revealed ulcerative lesions with enlarged folds at the greater curvature of the gastric body. Biopsy specimens of the lesions revealed poorly differentiated adenocarcinoma and signet ring cell carcinoma. The cancer was classified as stage IV with pancreatic invasion. Although NG with pangastritis is considered a high-risk factor for diffuse-type gastric carcinoma, the course of NG after eradication remains unknown. Careful histological assessment before eradication by endoscopic biopsy and close follow-up after eradication are therefore recommended, even in young patients.

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Section: Discussionmentioning

confidence: 43%

Gastric Cancer After Helicobacter pylori Eradication for Nodular Gastritis in an Adolescent

Okmaura¹,

Iwaya²,

Iwaya³

et al. 2022

Cureus

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“…NG is defined as antral gastritis with endoscopic findings typically characterized by a miliary pattern resembling “goose flesh” and is reportedly seen in NHPH 8 . NG is currently thought to be an early‐phase finding of H. pylori infection that is present in 80%–90% of young patients 14,15 . Since the HP group in the present investigation was limited to mild atrophy and contained young patients, the proportion of NG was presumably higher.…”

Section: Discussionmentioning

confidence: 77%

“…8 NG is currently thought to be an early-phase finding of H. pylori infection that is present in 80%-90% of young patients. 14,15 Since the HP group in the present investigation was limited to mild atrophy and contained young patients, the proportion of NG was presumably higher. However, there was no significant difference between the study groups.…”

Section: F I G U R E 3 (A)mentioning

confidence: 93%

Diagnosis by combination of endoscopic findings helps differentiate non‐Helicobacter pylori Helicobacter‐infected gastritis from Helicobacter pylori‐infected gastritis

Okamura,

Iwaya,

Nagaya

et al. 2024

Helicobacter

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BackgroundThe characteristic endoscopic findings of non‐Helicobacter pylori Helicobacter (NHPH) gastritis, including white marbled appearance and crack‐like mucosa, have been reported. However, these findings can also manifest in H. pylori (HP)‐infected gastritis. This study compared NHPH gastritis and mild atrophic HP gastritis to identify features that may enhance NHPH diagnosis.Materials and MethodsA total of 2087 patients underwent upper gastrointestinal endoscopy and were histologically evaluated by multiple gastric mucosal biopsies according to the updated Sydney System (USS) at Shinshu University Hospital between 2005 and 2023. Among them, nine patients were classified into the NHPH group and 134 patients with HP infection and mild atrophy were classified into the HP group for retrospective comparisons of endoscopic findings and clinicopathological characteristics.ResultsAll nine patients in the NHPH group (eight males [89%], median ± standard deviation [SD] age: 49 ± 13.0 years) were infected with H. suis. The 134 patients in the HP group contained 70 men (52%) and had a median ± SD age of 35 ± 19.9 years. Endoscopic findings were statistically comparable for white marbled appearance (three patients [33%] in the NHPH group and 37 patients [31%] in the HP group) and crack‐like mucosa (three patients [33%] and 27 patients [20%], respectively). Diffuse redness was significantly less frequent in the NHPH group (one patient [14%] vs. 97 patients [72%], p < 0.001). White marbled appearance or crack‐like mucosa without diffuse redness was significantly more common in the NHPH group (56% vs. 13%, p = 0.004), with a sensitivity and specificity of 56% and 87%, respectively. Mean USS neutrophil infiltration and Helicobacter density scores were significantly higher in the HP group (both p < 0.01), which might have influenced the endoscopic findings of diffuse redness.ConclusionsWhen endoscopic findings of white marbled appearance or cracked‐like mucosa are present, evaluation for diffuse redness may contribute to a more accurate diagnosis of NHPH gastritis.

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“…The most common endoscopic lesions in children were nodularity (60.7%), of which 83.8% were positive for H. pylori. Nodularity has been reported in infected children, ranging from 21 to 93% [11,13,[33][34][35][36]. It is a typical endoscopic finding in children with H. pylori infection [34,37].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study

Nguyen,

Tang,

et al. 2023

Healthcare

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Background: Helicobacter pylori (H. pylori) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children. Methods: We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children’s hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. H. pylori infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained. Results: Among 336 enrolled children aged 4–16 (mean: 9.1 ± 2.4 years; 55.4% girls), H. pylori infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. cagA+ strains were detected at a higher rate in children with ulcers. Conclusions: Prevalence of H. pylori and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of H. pylori to reduce ulcer risk and gastric cancer later.

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Clinicopathological features of nodular gastritis in three classes of age

Cited by 9 publications

References 18 publications

Gastric Cancer After Helicobacter pylori Eradication for Nodular Gastritis in an Adolescent

Gastric Cancer After Helicobacter pylori Eradication for Nodular Gastritis in an Adolescent

Diagnosis by combination of endoscopic findings helps differentiate non‐Helicobacter pylori Helicobacter‐infected gastritis from Helicobacter pylori‐infected gastritis

Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study

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