Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

Wei, Jianguo; Yang, Jianfeng; Liang, Wenqing; Xu, C.; Wen, Yuanyuan

doi:10.3892/ol.2018.9609

Cited by 5 publications

(15 citation statements)

References 25 publications

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“…Primary thyroid leiomyosarcoma is an exceptionally uncommon malignancy, constituting just 0.014% of thyroid cancers [1,2]. Reported cases are sparse in the literature, often affecting elderly females, with an average age of 61.4 years [3][4][5], though Tulbah et al, [6], reported a case of a leiomyosarcoma of the thyroid in a 6-year-old child with congenital immunodeficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Though the pathogenesis of this tumor remains uncertain, many authors incriminate the transformation of the smooth muscle-walled vessels in the thyroid gland capsule [4][5][6][7]. Others claim that it can result of metaplasia of the smooth muscle in a thyroid anaplastic carcinoma [8], or a malignant transformation of the smooth muscles, after an Epstein-Barr virus infection [6].…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of primary leiomyosarcoma within the thyroid gland is exceedingly rare, constituting only 0.014% of thyroid cancers [1,2]. Originating from tissues rich in smooth muscle, such as the retroperitoneum, pelvis, digestive tract, and skin, this aggressive tumor is associated with poor prognoses [3,4]. Surgical excision remains the gold standard treatment, with immunohistochemistry techniques aiding in its histological diagnosis [2].…”

Section: Introductionmentioning

confidence: 99%

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Rare Presentation: Primary Leiomyosarcoma of the Thyroid Gland

Rizkou,

Benhoummad,

Rochd

et al. 2024

Middle East Res J Case Rep

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Leiomyosarcoma, an uncommon tumor, becomes even rarer when it emerges within the thyroid gland. Diagnosing it accurately is a challenging task due to its atypical location, diverse clinical and radiological presentations, its rarity, and overlapping differential diagnoses. However, immunohistochemistry studies can offer a precise identification. In this article, we present a compelling case of recurrent primary leiomyosarcoma of the thyroid gland in a 23-year-old man, revealed by inspiratory dyspnea caused by a voluminous cervical mass and ultimately confirmed as leiomyosarcoma through histopathological examination.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rare Presentation: Primary Leiomyosarcoma of the Thyroid Gland

Rizkou,

Benhoummad,

Rochd

et al. 2024

Middle East Res J Case Rep

View full text Add to dashboard Cite

show abstract

“…The etiology of thyroid LMS remains unknown but may be related to smooth muscles of the vascular wall of the thyroid capsule [5]. Thyroid LMS is very rare, with only 30 cases reported worldwide [3]. The incidence of thyroid LMS is more common among the elderly, among individuals aged 40-90 years, and the male:female ratio is 1:1.5.…”

Section: Discussionmentioning

confidence: 99%

“…Primary thyroid LMS is primarily surgically resected, including thyroidectomy and total resection with cervical lymph node dissection, and no other effective treatment currently available. Disease progression is rapid, the prognosis is poor, and the 1-year survival rate is < 10% [3]. Here, we report the case of a 76year-old woman with thyroid LMS admitted to our hospital department and a review of the literature.…”

Section: Introductionmentioning

confidence: 94%

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Hao

Huang

Tian

et al. 2020

Preprint

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Background Primary thyroid leiomyosarcoma(LMS) is very rare, with only 30 cases reported worldwide. Thyroid LMS should be diagnosed with caution and comprehensively evaluated considering clinical, imaging, and pathological data. It is a kind of fatal tumor with an extremely poor prognosis and lacks effective treatment regimens, and most patients die within 1 year of diagnosis. Here, we present a case report on a patient with Primary thyroid LMS. Case presentation A 76-year-old woman presented with hoarseness, dysphagia, and dyspnea when lying down for the past 1 month visited our hospital. She had a history of right neck masses in the past 2 years. A hard, irregular tumor of approximately 8 cm × 5 cm × 5 cm was observed on the right lobe of the thyroid, the boundary between which and the surrounding tissues was unclear. The tumor anteriorly invaded the cervical muscles and interiorly invaded the right walls of the trachea and esophagus. Most tumor tissues were excised, a curative operation seemed impossible. Immunohistochemically, the tumor cells were positive for Calponin, vimentin and SMA, but negative for EMA, CK, P53, Desmin and S-100. Tumor recurrence and progression were considered two months after surgery, the patient refused follow-up treatment for personal reasons and died 4 months after surgery. Conclusion Thyroid LMS accounting for merely 0.014% of primary thyroid tumors of unknown etiology. The diagnosis can only be confirmed upon a lack of evidence regarding epithelial differentiation or other types of sarcoma differentiation and when immunohistochemistry yields positive smooth muscle markers. Primary thyroid LMS is primarily surgically resected and no other effective treatment currently available. Disease progression is rapid, the prognosis is poor, and the 1-year survival rate is <10%. In the present study, a rare case of a 76-year-old female patient diagnosed with thyroid LMS was reported and a review of the literature is presented.

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Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature

Asiri,

Alsarrani,

Altasan

et al. 2023

Thyroid Res

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Background Leiomyosarcoma (LMS) is a soft tissue malignant tumor that has a predilection to the abdominopelvic and limb smooth muscles. LMS of the thyroid is exceptionally rare. Papillary thyroid cancer (PTC) is the most common thyroid malignancy and originates from the thyroid epithelial layer. To our knowledge, the presence of both tumors in the same patient has not been reported previously. Case presentation & literature review A 42-year-old woman presented with a progressively enlarging neck mass for a few months. She underwent left thyroid lobectomy, and the histology showed high-grade primary LMS of the thyroid. She subsequently underwent a complete thyroidectomy, which identified a classical PTC on her right lobe. Our comprehensive literature review identified 39 published cases of primary LMS of the thyroid. The average tumor size was 5.88 cm and occurred more in women. The most common presentation was neck mass, followed by compressive symptoms. Recurrence and metastasis were uncommon at 15% and 10–25%, respectively. Conclusion Thyroid LMS is a rare malignancy with a worse prognosis than PTC. A thorough workup must be done to rule out metastasis before labeling it as primary thyroid cancer.

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Clinicopathological features of primary thyroid leiomyosarcoma without Epstein‑Barr virus infection: A case report

Cited by 5 publications

References 25 publications

Rare Presentation: Primary Leiomyosarcoma of the Thyroid Gland

Rare Presentation: Primary Leiomyosarcoma of the Thyroid Gland

A rare primary leiomyosarcoma of the thyroid gland: a case report and literature review

Primary leiomyosarcoma of the thyroid with concurrent papillary thyroid cancer: a rare case report and a review of literature

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