“…However, when searching the literature, we found that patients with this tumor subtype had a poor prognosis and a shorter survival time, which may be caused by the higher degree of malignancy in this tumor subtype and the difficulty of diagnosing this subtype in the early stage, which results in delayed treatment. Bradbury et al ( 24 ) reported 17 patients who received surgery/chemotherapy/radiotherapy, 4 who received radiotherapy alone, and 2 who received chemoradiotherapy, and the median survival time of the entire population was 16.1 months; another study found that the 5-year recurrence-free and overall survival rates were 70.4% and 81.5%, respectively ( 25 ). Therefore, we interpret that the clinical staging and histological grading of tumors and reasonable clinical treatment schemes are important factors affecting the prognosis of patients.…”