Clinicopathological features of pure mica pneumoconiosis associated with Sjögren syndrome

Kobayashi, Hideo; Ohara, Ichiyo; Kanoh, Soichiro; Motoyoshi, Kazuo; Aida, Shinsuke; Kohyama, Norihiko

doi:10.1002/ajim.10342

Cited by 9 publications

(7 citation statements)

References 8 publications

(13 reference statements)

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“…Sjögren's syndrome is accompanied by various pulmonary diseases 1,5–7 . Because subclinical Sjögren's syndrome can be difficult to diagnose, it is important to detect this syndrome by Saxon's test when investigating various pulmonary diseases 7 …”

Section: Discussionmentioning

confidence: 99%

Tracheo‐broncho‐bronchiolar lesions in Sjögren's syndrome

et al. 2007

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A 53-year-old woman reported having a persistent cough and bloody sputum. She did not smoke but had received a diagnosis of Sjögren's syndrome. Chest CT revealed middle lobe syndrome, bronchiectasis and diffuse centrilobular nodular lesions. Bronchoscopy displayed multiple whitish polypoid lesions protruding from the cartilage rings and tracheobronchopathia osteochondroplastica was histologically confirmed by the presence of bony tissue in the tracheo-bronchial wall. Video-assisted thoracoscopic biopsy demonstrated lymphocyte aggregation causing follicular broncho-bronchiolitis. Erythromycin therapy resulted in improvement of the follicular bronchiolitis but not the tracheobronchopathia osteochondroplastica.

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Section: Discussionmentioning

confidence: 99%

Tracheo‐broncho‐bronchiolar lesions in Sjögren's syndrome

et al. 2007

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“…Studies suggested that mica dust can cause pneumoconiosis [37], characterized by nodular and reticular infiltrates especially in the lower lung fields.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiopulmonary Stress of the China Clay Mine Workers

Pari

Dhara

2012

Int J Occup Safety & Health

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Background: Several risk factors are associated with cardiopulmonary stress of industrial workers. Most important factors are job strain, job demand, physical effort, work station environment etc. In India, study on occupational cardiopulmonary stress among china clay miners is scanty. Objectives: The present study was aimed to evaluate the cardiopulmonary stresses of the china clay mine workers. Methods: The investigation was carried out on male workers from different china clay mines in the Birbhum district, West Bengal. The cardiovascular stress was evaluated by noting pulse rate of the subjects both during rest and during performance of different types of mine tasks. The cardiovascular stress index (CSI) was evaluated in different mine task. The work rest cycle of different china clay mine tasks was analyzed by video-photographic method. Different pulmonary function parameters, viz, FVC, FEV1, FER and PEF were measured by a digital spirometer to assess the severity of Chronic Obstructive Pulmonary Disease (COPD). Results: The results showed that the working pulse rate and CSI vary with different mine task. It was highest in subjects carrying china clay by head mode. The magnitude of CSI was found to vary with the change of work time and the rest time among the workers. Pulmonary function parameters of china clay mine workers were significantly lower (P<0.01) than other industrial workers. About 79% of total population was suffering from different grades of COPD. Among them, 12% were suffering from severe COPD and 60% from moderate COPD. The higher prevalence of COPD among china clay mine workers might be due to exposure of china clay dust in the work place. Conclusion: It was concluded that the china clay mine workers were suffering from high degree of physiological stress while performing different mine tasks.DOI: http://dx.doi.org/10.3126/ijosh.v2i2.6594 International Journal of Occupational Safety and Health, Vol 2. No 2 (2012) 27-33

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“…However, such fibrotic patterns were unlike concentric fibrosis, as observed mostly in silicosis. 4,5 The use of advanced physicochemical analytical techniques, such as scanning electron microscopyenergy dispersive xray spectroscopy and analytical transmission electron microscopy of biopsy samples and bronchoalveolar lavage samples of patients with occupational exposure, confirmed the particles as pure mica. [3][4][5] One report 5 also showed an unusual autoimmune disease associated with mica pneumo coniosis.…”

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confidence: 97%

“…It is well established that mica miners and millers are at increased risk of pneumoconiosis and that mica alone is fibrogenic, even in the absence of other potential occupational or environmental hazards, which are known to cause fibrosis. 1,[3][4][5] Mica pneumoconiosis is still considered a rare disease largely because occupational disease outbreaks occurring in the informal labour sector are not usually formally documented. Several studies 1,4 published in the past two decades provide substantial information about micaassociated pneumoconiosis and show that the disease has a complex set of clinical manifestations.…”

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“…The diagnosis of mica pneumo coniosis is complex due to its diverse patho physiological characteristics, many of which mimic those caused by conventional exposures. Moreover, mica pneumo coniosis can have a very long latency period (sometimes as long as 40 years), 5 and disease progression can continue even after cessation of exposure. Furthermore, mica co exposure might associate with mixed dust pneumoconiosis, conditions in which the involvement of the mica is often underdiagnosed.…”

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