Clinicopathological features of recurrence after radical surgery for nonmetastatic renal cell carcinoma

Abstract

These findings suggest that careful follow-up should be performed for patients showing a high pathological stage after radical surgery for nonmetastatic RCC, because of the higher probability of disease recurrence, and that after recurrence, intensive treatment should be considered, particularly for patients with unresectable recurrent disease occurring within 1 year after initial radical surgery.

Organ‐confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size

“…Using these criteria the interobserver agreement was substantial, bordering on almost perfect (Cohen's kappa 0.75). The frequency of MVI found in our study is in concordance with some previous reports (6, 7, 9, 13) (17%, 42.7%, 25% and 4.7%, respectively). There is, however, considerable variation in reported frequencies of MVI.…”

“…In the study by Sevinç et al, which was limited by the small population considered, CSS was not found to be significantly related to MVI (6). In our study, however, MVI turned out to be a strong independent prognosticator for organ‐confined CCRCC after RN, a finding in accordance with most of the few previous reports dealing with this issue (5, 7, 9). Our patients with MVI‐positive tumours experienced a nearly 7‐fold higher risk of dying from CCRCC compared to patients with tumours without MVI at surgery.…”

“…The importance of microvascular invasion (MVI) for prognosis in non-metastatic RCC has been discussed in a few earlier reports with divergent conclusions (5)(6)(7)(8)(9)(10)(11). Likewise, the predictive relevance of T-stage, tumour size (TS) and nuclear grade (NG) for development of meta-chronous distant metastases (MDM) in localized RCC has been questioned (12,13).…”

The prognostic relevance of interactions between venous invasion, lymph node involvement and distant metastases in renal cell carcinoma after radical nephrectomy

“…In univariate analysis we did find a survival advantage in favour of incidentally detected RCC compared with symptomatic RCC. However, in keeping with the findings of Ishimura et al [ 20 ] and Gudbjartsson et al [ 21 ], the independent prognostic significance of mode of presentation was not confirmed in multivariate analysis. In agreement with other studies, [ 4 , 22 ] we found that elevated ESR at presentation was associated with more aggressive disease and poorer outcome for both clear cell and papillary RCC (data not shown).…”

“…The symptoms of RCC at presentation have been associated with poor outcome [ 3 , 18 , 20 ]. In univariate analysis we did find a survival advantage in favour of incidentally detected RCC compared with symptomatic RCC.…”