Clinicopathological features of superficial squamous cell carcinoma of the esophagus

Tachibana, Mitsuo; Yoshimura, Hiroshi; Kinugasa, Shoichi; Hashimoto, Naoki; Dhar, Dipok Kumar; Abe, Shogo; Monden, Naomi; Nagasue, Naofumi

doi:10.1016/s0002-9610(97)00046-9

Cited by 66 publications

(52 citation statements)

References 16 publications

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“…Due to the higher aggressiveness of SCC, positive lymph nodes in m3 mucosa infiltration are reported which range from 0% to 23% [12,13,[27][28][29].…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2‐40 immunostaining

Gockel

Domeyer

Sgourakis

et al. 2009

Journal of Surgical Oncology

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Lymph node positivity and lymphatic vessel infiltration did not linearly increase with sm tumor infiltration depth. The risk category of lymph node involvement in superficial esophageal cancer exists according to our prediction model on the basis of tumor size of >2 cm and microvascular infiltration. The hitherto common sm levels 1-3 classification of submucosal cancers appears to display a lesser impact than previously assumed with regard to prediction of potential lymph node metastases and consequently the indication for endoscopic or surgical therapy.

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“…Due to the higher aggressiveness of SCC, positive lymph nodes in m3 mucosa infiltration are reported which range from 0% to 23% [12,13,[27][28][29].…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2‐40 immunostaining

Gockel

Domeyer

Sgourakis

et al. 2009

Journal of Surgical Oncology

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“…1). 2,[11][12][13] Immunohistochemical staining Immunohistochemical staining for P53, MIB-1, pRB, and cyclin D1 was performed on serial sections containing the most invasive lesion in the tumors of all 84 patients. Anti-P53 monoclonal antibody (DO-7, DAKO, Glostrup, Denmark) was used at a dilution with 1:100, cyclin D1 (DCS-6, DAKO) 1:1000, pRB (G3-245, Pharmingen, San Diego, CA) 1:500, and anti-MIB-1 (Immunotech, Marseille, France) 1:50.…”

Section: Patientsmentioning

confidence: 99%

Evaluation of an Indicator for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma Invading the Submucosal Layer

Nakajima¹,

Nagai²,

Miyaké³

et al. 2002

Japanese Journal of Cancer Research

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Lymph node metastasis is a major prognostic factor for esophageal squamous cell carcinoma (ESCC). In recent years, endoscopic mucosal resection (EMR) has been developed with excellent results for the treatment of the superficial ESCC. To make the EMR treatment successful, it is important to establish a good indicator to identify ESCC patients at a high risk of lymph node metastasis. In this study, we examined clinicopathological and immunohistochemical factors to investigate the factors involved in lymph node metastasis of ESCC invading to the submucosal layer (sm‐ESCC). Surgical specimens from 84 sm‐ESCC patients were examined. Among 84 sm‐ESCC patients, 33 (39.3%) had lymph node metastases. Clinicopathologically, tumor depth, lymphatic invasion and blood vessel invasion showed significant correlations with lymph node metastasis by univariate analysis. Tumor depth and lymphatic invasion showed significant correlations by multivariate analysis of these factors. Immunohistochemically, P53 accumulation was observed in 45 cases (53.6%), cyclin D1 overexpression in 25 (29.8%), and pRB in 65 (77.4%). P53 accumulation, cyclin D1 overexpression and MIB‐1 Labeling Index were significantly associated with lymph node metastasis by univariate analysis, and P53 accumulation showed a significant correlation with lymph node metastasis by multivariate analysis. Among tumor depth, lymphatic invasion and P53 accumulation, tumor depth and lymphatic invasion were significantly correlated with lymph node metastasis (P=0.0023 and P=0.0092, respectively) by multivariate analysis. These data suggest that tumor depth and lymphatic invasion can be considered as good indicators for lymph node metastasis among patients with sm‐ESCC. In addition, P53 accumulation could be helpful to identify the patients who need additional treatment after EMR.

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“…the muscularis mucosa; sm1, tumors invading the most superficial 1/3 of the submucosa; sm2/3, tumors invading deeper than sm1 level) (16,(18)(19)(20)(21)(22). Eguchi et al (21) demonstrated that lymph node metastasis was found in 0, 6, 18, 53 and 54% of m1, m2, m3, sm1 and sm2/3 lesions, respectively.…”

Section: Discussionmentioning

confidence: 99%

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

Hiyoshi

Watanabe²,

Hirashima³

et al. 2009

Oncol Rep

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Abstract. p12 CDK2-associating protein 1 (p12 CDK2-AP1 ) is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. In addition, p12CDK2-AP1 has also been shown to interfere in DNA replication. A reduction of p12 CDK2-AP1 expression is known to be a negative prognostic indicator in patients with oral squamous cell carcinoma. To elucidate the role of p12 CDK2-AP1 expression in esophageal squamous cell carcinoma (ESCC), we immunohistochemically examined the expression of p12 CDK2-AP1 protein in 120 resected ESCC specimens and determined its association with the clinicopathological characteristics and prognosis. Of the 120 ESCCs, 79 (65.8%) showed positive staining (≥25% of cancer cells showing p12 CDK2-AP1 expression), while 41 (34.2%) lacked the staining (<25% of cancer cells showing p12 CDK2-AP1 expression). Negative staining for p12 CDK2-AP1 was found to be significantly associated with advanced lesions [depth of tumor (P=0.001), lymph node metastasis (P<0.001), pathological stage (P<0.0001) and venous invasion (P<0.0001)], and a poor prognosis (disease-free survival and overall survival: log-rank P<0.05). The rate of lymph node metastasis in patients with p12 CDK2-AP1 negative-T1 ESCC was significantly higher than that in patients with p12 CDK2-AP1 positive one (P<0.05). These results suggest the downregulation of p12 CDK2-AP1 to be related to tumor aggressiveness and a poor prognosis in patients with ESCC.

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Clinicopathological features of superficial squamous cell carcinoma of the esophagus

Cited by 66 publications

References 16 publications

Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2‐40 immunostaining

Prediction model of lymph node metastasis in superficial esophageal adenocarcinoma and squamous cell cancer including D2‐40 immunostaining

Evaluation of an Indicator for Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma Invading the Submucosal Layer

p12CDK2-AP1 is associated with tumor progression and a poor prognosis in esophageal squamous cell carcinoma

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