Clinicopathological features of tumor mutation burden, Epstein-Barr virus infection, microsatellite instability and PD-L1 status in Chinese patients with gastric cancer

Zhang, Li; Wang, Yinkui; Li, Zhongwu; Lin, Dongmei; Liu, Yiqiang; Zhou, Liyi; Wang, Dongliang; Wu, Aiwen; Li, Ziyu

doi:10.1186/s13000-021-01099-y

Cited by 15 publications

(13 citation statements)

References 42 publications

(23 reference statements)

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“…MSI and TMB have recently attracted widespread attention as promising predictive biomarkers for the efficacy of immunotherapy, and related studies in gastric cancer have gradually increased ( Wei et al, 2021 ; Zhang et al, 2021 ). Our results show that 13 types of TIICs are significantly related to TMB in the GC microenvironment, and 8 types of TIICs are closely related to MSI.…”

Section: Discussionmentioning

confidence: 99%

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

Zhang

Yuan

Liang

et al. 2022

Front. Cell Dev. Biol.

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Immunotherapy has developed rapidly and has gradually become one of the important methods for treatment of gastric cancer (GC). The research on tumor infiltrating immune cells (TIICs) and immune-related genes in the tumor microenvironment (TME) greatly encourages the development of immunotherapy. The devolution algorithm (CIBERSORT) was applied to infer the proportion of 22 TIICs based on gene expression profiles of GC tissues, which were downloaded from TCGA and GEO. TCGA was utilized to analyze the differential expression of immune-related genes, and explore the potential molecular functions of these genes. We have observed the enrichment of multiple TIICs in microenvironment of GC. Some of these cells were closely related to tumor mutational burden (TMB), microsatellite instability (MSI), Fuhrman grade, and TNM staging. Survival analysis showed that the infiltration level of CD8+ T cells, activated CD4+ memory T cells and M2 macrophages were significantly related to the prognosis of GC patients. The functional enrichment analysis of immune-related genes revealed that these genes were mainly associated with cytokine activation and response. Four significant modules were screened by PPI network and 20 key genes were screened from the modules. The expression levels of CALCR and PTH1R are strikingly related to the expression of immune checkpoint and the prognosis of GC patients. The type and number of TIICs in microenvironment of GC, as well as immune-related genes are closely related to tumor progression, and can be used as important indicators for patient prognosis assessment.

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Section: Discussionmentioning

confidence: 99%

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

Zhang

Yuan

Liang

et al. 2022

Front. Cell Dev. Biol.

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“…The mutation of the DDR gene in cancer cells is usually associated with the increased expression of PD-1/PD-L1 genes within the TME [ 56 , 64 , 233 , 234 ], such as the DSB repair gene [ 221 ], MMR gene [ 146 , 235 , 236 ] and RB1 [ 171 , 237 ]. The expression of BER/SSBR has been shown to be negatively correlated with the level of PD-L1 observed in cancer cells [ 150 , 235 ].…”

Section: The Mechanism Of Altered Ddr Pathway Affecting the Efficacy ...mentioning

confidence: 99%

The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

Shi

Qin

Lin

et al. 2022

J Exp Clin Cancer Res

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As our understanding of the mechanisms of cancer treatment has increased, a growing number of studies demonstrate pathways through which DNA damage repair (DDR) affects the immune system. At the same time, the varied response of patients to immune checkpoint blockade (ICB) therapy has prompted the discovery of various predictive biomarkers and the study of combination therapy. Here, our investigation explores the interactions involved in combination therapy, accompanied by a review that summarizes currently identified and promising predictors of response to immune checkpoint inhibitors (ICIs) that are useful for classifying oncology patients. In addition, this work, which discusses immunogenicity and several components of the tumor immune microenvironment, serves to illustrate the mechanism by which higher response rates and improved efficacy of DDR inhibitors (DDRi) in combination with ICIs are achieved.

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“…The gene mutations in TMB-L GC patients were mainly in ERBB2, CCNE1, CDK12 and CCND1 ( Yu et al, 2021 ). There have also been other reports that mutations in the LRP1B gene are so prominent, in Chinese GC patients with high TMB ( Zhang et al, 2021 ).…”

Section: Lncrnas Have Superior Values In Optimizing Patients’ Selecti...mentioning

confidence: 89%

LncRNA and its role in gastric cancer immunotherapy

Zhang

Wang

Yang³

et al. 2023

Front. Cell Dev. Biol.

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Gastric cancer (GC) is a potential dominant disease in tumor immunotherapy checkpoint inhibitors, and adoptive cell therapy have brought great hope to GC patients. However, only some patients with GC can benefit from immunotherapy, and some patients develop drug resistance. More and more studies have shown that long non-coding RNAs (lncRNAs) may be important in GC immunotherapy’s prognosis and drug resistance. Here, we summarize the differential expression of lncRNAs in GC and their impact on the curative effect of GC immunotherapy, discuss potential mechanisms of activity in GC immunotherapy resistance regulated by lncRNAs. This paper reviews the differential expression of lncRNA in GC and its effect on immunotherapy efficacy in GC. In terms of genomic stability, inhibitory immune checkpoint molecular expression, the cross-talk between lncRNA and immune-related characteristics of GC was summarized, including tumor mutation burden (TMB), microsatellite instability (MSI), and Programmed death 1 (PD-1). At the same time, this paper reviewed the mechanism of tumor-induced antigen presentation and upregulation of immunosuppressive factors, as well as the association between Fas system and lncRNA, immune microenvironment (TIME) and lncRNA, and summarized the functional role of lncRNA in tumor immune evasion and immunotherapy resistance.

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Clinicopathological features of tumor mutation burden, Epstein-Barr virus infection, microsatellite instability and PD-L1 status in Chinese patients with gastric cancer

Cited by 15 publications

References 42 publications

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

Immune Infiltration in Gastric Cancer Microenvironment and Its Clinical Significance

The role of DNA damage repair (DDR) system in response to immune checkpoint inhibitor (ICI) therapy

LncRNA and its role in gastric cancer immunotherapy

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