Clinicopathological importance of colorectal medullary carcinoma

Zenger, Serkan; Gürbüz, Birgül; Can, Uğur; Bilgiç, Çağrı; Sobutay, Erman; Yılmaz, Serpil; Balık, Emre; Yaltı, Tunç; Kapran, Yersu; Buğra, Dursun

doi:10.1007/s10353-019-00613-3

Cited by 2 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All 7 (64%) MMR deficient cases were also MSI-H. The MMR deficiency and MSI patterns seen in our study are consistent with what has been previously described [ 4 , 13 ]. Metastatic disease was seen in 2 cases to the abdominal wall and scapula.…”

Section: Discussionsupporting

confidence: 92%

Medullary colonic carcinomas present with early-stage disease and do not express neuroendocrine markers by immunohistochemistry

Abada

Jang

Kim

et al. 2023

aog

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Medullary colonic carcinomas present with early-stage disease and do not express neuroendocrine markers by immunohistochemistry

Abada

Jang

Kim

et al. 2023

aog

View full text Add to dashboard Cite

“…LELC is rare in the urinary bladder (0.4-1.3%), lungs (<1%), esophagus (<1%), salivary glands (<1%), liver (<1%), and pancreas (<1%). [8][9][10][11] To the best of the authors' knowledge, only four cases of LELC in the gall bladder have been reported.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity

Jain

Goyal

Sakhuja

et al. 2021

Korean J Gastroenterol

View full text Add to dashboard Cite

Schmincke described lymphoepithelioma as an undifferentiated carcinoma with abundant lymphoid stroma in the nasopharynx. Tumors with a similar histomorphology in extrapharyngeal areas have been referred to as lymphoepithelioma-like carcinoma (LELC). The association of an Ebstein-Barr virus (EBV) infection with lymphoepithelioma is well established in the nasopharynx but not so well at the extrapharyngeal sites. Only four cases of LELC have been reported in the gall bladder, of which all were negative for the EBV. This paper reports the first case of an EBV-associated mixed gall bladder carcinoma exhibiting a distinct phenotype of LELC and adenocarcinoma with mucinous differentiation. The EBV was confirmed by the strong granular membranous and cytoplasmic expression of LMP-1 (latent membrane protein-1) on immunohistochemistry and nuclear EBER RNA on chromogen in-situ hybridization in the tumor. This is the first case of LELC positive for EBV in the gall bladder. LELC has a more favorable prognosis than conventional adenocarcinoma or squamous cell carcinoma, irrespective of the site. Although a higher T stage and nodal metastasis were exceptional in the present case in contrast to the previous cases, the EBV-associated lymphocytic response might limit the disease spread and confer better overall survival and prognosis in these patients. Nevertheless, more prospective studies with a larger cohort will be needed to understand the pathogenesis, biological behavior, and prognosis of this rare entity.

show abstract

Clinicopathological importance of colorectal medullary carcinoma

Cited by 2 publications

References 38 publications

Medullary colonic carcinomas present with early-stage disease and do not express neuroendocrine markers by immunohistochemistry

Medullary colonic carcinomas present with early-stage disease and do not express neuroendocrine markers by immunohistochemistry

Epstein-Barr Virus-associated Mixed Lymphoepithelioma-like Carcinoma and Adenocarcinoma of the Gall Bladder: An Unusual Entity

Contact Info

Product

Resources

About