Clinicopathological Patterns of Malignant Solid Tumors in Adult Patients: A Hospital-Based Study From Bangladesh

Siddika, Ayesha; Chowdhury, Shyamal; Hasan, Md Rockyb; Moniruzzaman, Md.; Sayeed, S K Jakaria Been; Tabassum, Tahsin; Chowduary, Mahidul; Tabassum, Tanzin; Islam, A. B. M. Saiful; Rahman, Md. Mujibur

doi:10.7759/cureus.34925

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Regulation of abnormal genes most frequently results in the incidence and proliferation of cancers [ 46 ]. Currently, PHF5A participation in the incidence and proliferation of numerous cancers like lung cancer, breast cancer, colorectal tumors, endometrial tumors, squamous cell carcinoma, oral cell carcinoma, and hepatocellular carcinoma has been elucidated [ 66 ]. Accordingly, PHF5A regulates the activation of proto-oncogenes/proteins through dysregulated or abnormal alternative splicing of different transcription factors and cofactors [ 35 , 36 , 49 , [67] , [68] , [69] ].…”

Section: Phf5a Participation In Cancer Progressionmentioning

confidence: 99%

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PHF5A as a new OncoTarget and therapeutic prospects

Li¹,

Liu²,

Wang³

et al. 2023

Heliyon

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Section: Phf5a Participation In Cancer Progressionmentioning

confidence: 99%

“… Falck, E. and K. Klinga-Levan. (2013) [ 66 ]. GBM stem cells Splicing factor Enhanced recognition of C-rich 3′ splice site exons Promote the proliferation of GBM stem cells and the occurrence and development of xenograft tumors Hubert, C.G.…”

Section: Phf5a Participation In Cancer Progressionmentioning

confidence: 99%

PHF5A as a new OncoTarget and therapeutic prospects

Li¹,

Liu²,

Wang³

et al. 2023

Heliyon

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“…Tumors are a heterogeneous group of cell masses that arise in various organs or tissues, including the central nervous system [1,2]. These abnormal, heterogeneous cellular masses are composed of tumor cells, stromal cells, and immune cells that interact in an intricate manner and are modulated via the fluctuations in humoral, genetic, molecular, and tumor microenvironment cues that influence tumor growth or suppression.…”

Section: Introductionmentioning

confidence: 99%

Tumor Dormancy and Reactivation: The Role of Heat Shock Proteins

Amissah,

Combs,

Shevtsov

2024

Cells

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Tumors are a heterogeneous group of cell masses originating in various organs or tissues. The cellular composition of the tumor cell mass interacts in an intricate manner, influenced by humoral, genetic, molecular, and tumor microenvironment cues that dictate tumor growth or suppression. As a result, tumors undergo a period of a dormant state before their clinically discernible stage, which surpasses the clinical dormancy threshold. Moreover, as a genetically imprinted strategy, early-seeder cells, a distinct population of tumor cells, break off to dock nearby or extravasate into blood vessels to secondary tissues, where they form disseminated solitary dormant tumor cells with reversible capacity. Among the various mechanisms underlying the dormant tumor mass and dormant tumor cell formation, heat shock proteins (HSPs) might play one of the most important roles in how the dormancy program plays out. It is known that numerous aberrant cellular processes, such as malignant transformation, cancer cell stemness, tumor invasion, metastasis, angiogenesis, and signaling pathway maintenance, are influenced by the HSPs. An accumulating body of knowledge suggests that HSPs may be involved in the angiogenic switch, immune editing, and extracellular matrix (ECM) remodeling cascades, crucial genetically imprinted strategies important to the tumor dormancy initiation and dormancy maintenance program. In this review, we highlight the biological events that orchestrate the dormancy state and the body of work that has been conducted on the dynamics of HSPs in a tumor mass, as well as tumor cell dormancy and reactivation. Additionally, we propose a conceptual framework that could possibly underlie dormant tumor reactivation in metastatic relapse.

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