Clinicopathological profile of primary bronchogenic carcinoma treated in a tertiary care hospital of western Nepal

Abstract

Background: Bronchogenic carcinoma is the most common cancer in Nepal. There is no information available about the incidence and clinicopathological features of bronchogenic carcinoma from Nepal. We aimed to study the clinicopathological features of primary bronchogenic carcinoma treated in a tertiary care hospital. Methods: A retrospective case-series analysis of 136 cases of primary bronchogenic carcinoma treated between September 2001 and August 2005 in a tertiary care hospital of western Nepal was performed. Results: The median age of the male and female patients was 67 (interquartile range 60, 71.75) and 66 (interquartile range 60, 70) years, respectively. The maximum number of patients was in the 60-69 year age group. One-hundred and thirteen (83.1%) of these patients were smokers. Among the male patients, 83.3% (60/72) were smokers and females 82.8% (53/64) were smokers. The male to female ratio of the patients was 1.1: 1. The most common histological type was squamous-cell carcinoma (51.5%), followed by small-cell carcinoma (17.6%) and adenocarcinoma (8.1%). Ninety-eight (72.1%) patients were diagnosed in late stages of the disease (IIIb and IV). Conclusion: The clinicopathological features are in accordance with reports from other studies. The results of the present study indicate that bronchogenic carcinoma has a higher average age incidence, higher proportion of female patients and higher proportion of diagnosis of the disease in late stages. The higher rate of bronchogenic carcinoma among females indicates scope for further research into risk factors. Intervention measures for prevention and early diagnosis of bronchogenic carcinoma are to be undertaken.

Study of Lung Cancer in a rural Medical College in hilly area of West Bengal

“…Our data shows that unexplained cough of several weeks is the commonest symptoms along with followed by chest pain, and shortness of breath. This is similar to reports published in the literature from different part of India 4,5,6 .…”

“…Smoking was the most common predisposing factor (86.36%), which included beedis in majority of cases. Similar observation has been reported by other Indian studies also 4,5,6 . In study by Noronha V et al, smoking tobacco remains the single most important risk factor (80-90%); a smaller proportion (10-20%) is attributed to occupational exposure to various carcinogenic agents 7 .…”

“…SCC was still the commonest cell type seen, followed by adenocarcinoma and SLCC. This is similar to reports from some other part of India and Nepal 4,5,6,9 . This difference in histopathology may be due to the fact that smoking is quite prevalent in this part of Bengal and in many cases, only cytology was performed.…”

“…Most of our study belonged to the patients of age group between 40-60 years .Similar observation was seen in other studies 4,5,6 . M:F ratio 6.12:1 similar to other study in Bengal 5 .…”

Lung Cancer in Malabar Cancer Center in Kerala - A Descriptive Analysis

“…The present study reveals that about 91% of the male cases had smoking habit; whereas among females smoking is comparatively less, but the influence of passive smoking is significantly remarkable. The increased proportion in smoking status correlates with the studies from other developing nations (Chandrasekhar et al, 2006;Hassan et al, 2010) and report from different parts of India (Gupta et al, 1998;Prasad et al, 2004Prasad et al, : 2009Khan et al, 2006;Rawat et al, 2009;Singh et al, 2010). Higher prevalence of tobacco use among male could be due to easiness in availability and cheaper cost of such items.…”