Clinicopathological Significance of Lymphangiogenesis and Tumor Lymphovascular Invasion in Indonesian Breast Cancers

Widodo, Irianiwati; Ferronika, Paranita; Harijadi, Ahmad; Utoro, Totok

doi:10.7314/apjcp.2013.14.2.997

Cited by 10 publications

(14 citation statements)

References 16 publications

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“…According to the detection area of lymphatic vessels, the included 12 studies were divided into three subgroups as follows: total LVD (without distinguishing peritumoral and intratumoral) ( n = 7) [11, 17, 24, 25, 27, 29, 31], peritumoral LVD ( n = 5) [16, 18, 22, 36, 38], and intratumoral LVD ( n = 3) [18, 22, 38]. The main outcomes are summarized in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

“…According to the detection area of lymphatic vessels, the studies were also divided into three subgroups of total LVD ( n = 15) [11, 12, 14, 15, 17, 19, 20, 24, 25, 27–31, 37], peritumoral LVD ( n = 8) [16, 18, 22, 27, 34–36, 38], and intratumoral LVD ( n = 5) [18, 22, 27, 34, 38]. The pooled Fisher's Z values were show in Figure 3, corresponding to the r values of total LVD ( r = 0.32, 95% CI: 0.19 to 0.45), peritumoral LVD ( r = 0.33, 95% CI: 0.18 to 0.46), intratumoral LVD ( r = 0.29, 95% CI: 0.04 to 0.50), and overall LVD ( r = 0.32, 95% CI: 0.23 to 0.40), respectively (Figure 3, Table 4).…”

Section: Resultsmentioning

confidence: 99%

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The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

Zhang

et al. 2016

Oncotarget

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Lymph node status is one of the key parameters used for determining the stage of breast cancer progression. The relationship of lymphatic vessel density (LVD), lymphovascular invasion (LVI), and lymph node metastasis (LNM) has not been clearly demonstrated yet. Databases of PubMed, Embase, and Web of Science were searched from inception up to 25 May 2016. Spearman correlation coefficient (r) and 95% confidence interval (CI) were used to determine the relationship within each group. Based on pre-established inclusion criteria, 28 studies involving 2920 breast cancer patients were included in this study. The r values of LVD-LVI, LVD-LNM, and LVI-LNM were 0.45 (95% CI: 0.31 to 0.57), 0.32 (95% CI: 0.23 to 0.40), and 0.24 (95% CI: 0.19 to 0.28), respectively. Compared with intratumoral LVD, peritumoral LVD showed more robust correlation with LVI (r = 0.53, 95% CI: 0.27 to 0.72) and LNM (r = 0.33, 95% CI: 0.18 to 0.46). The patients in LNM positive group presented with higher LVI detection rate of 45.85%, while in LNM negative group with detection rate of 23.85%. The results describe a triangle relationship between LVD, LVI, and LNM in breast cancer. Both LVD and LVI are indicated to be valuable predictors of LNM occurrence. Compared with intratumoral lymphatic vessels, peritumoral lymphatics might be the main disseminate route for breast tumor cells.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

Zhang

et al. 2016

Oncotarget

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“…Previous study reported that 65% of Indonesian breast cancers were found already in late stage, poor grade and with lymph nodes metastasis (Widodo et al, 2013). Therefore, study of clinicopathological features of Indonesian breast cancers with different molecular subtypes need to be done, in order to determine proper cancer management and prognosis.…”

Section: Clinicopathological Features Of Indonesian Breast Cancers Wimentioning

confidence: 99%

Clinicopathological Features of Indonesian Breast Cancers with Different Molecular Subtypes

Widodo

Dwianingsih²,

Triningsih³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Lymphovascular invasion that can be seen early in the periphery of a breast tumor can be viewed as a marker on angiogenesis / neovascularisation started up in the tumor considers Widodo et al, 2013. Endothelial growth factor (VEGF) can be a key mediator in tumour angiogenesis according Stoner et al, 2004;Garvin et al, 2005;Widodo et al, 2013;Huang et al, 2014.…”

Section: Discussionmentioning

confidence: 99%

“…Endothelial growth factor (VEGF) can be a key mediator in tumour angiogenesis according Stoner et al, 2004;Garvin et al, 2005;Widodo et al, 2013;Huang et al, 2014. Tamoxifen, which is a selective estrogen receptor modulator, for the treatment of breast cancer has the opposite effect compared with estrogen.…”

Section: Discussionmentioning

confidence: 99%

Hormone Use is Associated with Lymphovascular Invasion in Breast Cancer

Lööf-Johanson¹,

Brudin²,

Sundquist³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Clinicopathological Significance of Lymphangiogenesis and Tumor Lymphovascular Invasion in Indonesian Breast Cancers

Cited by 10 publications

References 16 publications

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

The relationship of lymphatic vessel density, lymphovascular invasion, and lymph node metastasis in breast cancer: a systematic review and meta-analysis

Clinicopathological Features of Indonesian Breast Cancers with Different Molecular Subtypes

Hormone Use is Associated with Lymphovascular Invasion in Breast Cancer

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