Clinicopathological significance of SNPs in <i>RAD51</i> and <i>XRCC3</i> in oral and oropharyngeal carcinomas

Santos, Edilmar de Moura; Santos, Hellen Bandeira de Pontes; Matos, Felipe Rodrigues de; Machado, Renato Assis; Coletta, Ricardo D.; Galvão, Hébel Cavalcanti; Freitas, Roseana de Almeida

doi:10.1111/odi.12943

Cited by 14 publications

(6 citation statements)

References 39 publications

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“…Interestingly, a large number of population-based studies reported an association between the studied variant and disease risk. Synergistic effects of the risk alleles of some SNPs with environmental factors on the susceptibility to such diseases were also reported in several studies [ 76 , 77 ]. Point mutations have been introduced as a source of de novo genetic diseases [ 78 ].…”

Section: Clinical Significance Of Snp Mutationsmentioning

confidence: 55%

Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review

et al. 2021

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Single-nucleotide polymorphisms (SNPs) are the simplest and most common type of DNA variations in the human genome. This class of attractive genetic markers, along with point mutations, have been associated with the risk of developing a wide range of diseases, including cancer, cardiovascular diseases, autoimmune diseases, and neurodegenerative diseases. Several existing methods to detect SNPs and mutations in body fluids have faced limitations. Therefore, there is a need to focus on developing noninvasive future polymerase chain reaction (PCR)–free tools to detect low-abundant SNPs in such specimens. The detection of small concentrations of SNPs in the presence of a large background of wild-type genes is the biggest hurdle. Hence, the screening and detection of SNPs need efficient and straightforward strategies. Suitable amplification methods are being explored to avoid high-throughput settings and laborious efforts. Therefore, currently, DNA sensing methods are being explored for the ultrasensitive detection of SNPs based on the concept of nanotechnology. Owing to their small size and improved surface area, nanomaterials hold the extensive capacity to be used as biosensors in the genotyping and highly sensitive recognition of single-base mismatch in the presence of incomparable wild-type DNA fragments. Different nanomaterials have been combined with imaging and sensing techniques and amplification methods to facilitate the less time-consuming and easy detection of SNPs in different diseases. This review aims to highlight some of the most recent findings on the aspects of nanotechnology-based SNP sensing methods used for the specific and ultrasensitive detection of low-concentration SNPs and rare mutations.

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Section: Clinical Significance Of Snp Mutationsmentioning

confidence: 55%

Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review

et al. 2021

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“…According to the inclusion and exclusion criteria, ten papers involving a total of 2484 controls and 2377 cases were enrolled in our analysis after selection [29, 31–39]. The progress of paper selection is demonstrated in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…To date, a variety of articles have been conducted to assess the correlation between the RAD51 gene polymorphisms and the risk of HNC and EC [29–39]. However, the results are still inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

Zhang

2019

International Journal of Genomics

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Background The role of RAD51 gene polymorphisms with the development of head and neck cancer (HNC) and esophageal cancer (EC) remains controversial. This meta-analysis was conducted to evaluate the correlation between the RAD51 polymorphisms and these two cancers quantitatively. Methods Databases of PubMed, Web of Science, and Embase were used to search relevant papers prior to August 17, 2019. STATA 11.0 was performed to observe the correlation. Results Ten relevant papers were enrolled in our analysis. Overall, a significant correlation was observed between the rs1801320 polymorphism and the increased risk of these two cancers (OR = 1.32, 95%CI = 1.03‐1.71 for C vs. G; OR = 1.50, 95%CI = 1.03‐2.19 for CG vs. GG; and OR = 1.44, 95%CI = 1.05‐1.99 for CC+CG vs. GG). In subgroup analyses, an increased risk was found for EC (OR = 2.07, 95%CI = 1.01‐4.25 for C vs. G; OR = 2.08, 95%CI = 1.17‐3.71 for CC vs. GG; and OR = 1.78, 95%CI = 1.00‐3.15 for CC vs. CG+GG), but not for HNC. Moreover, our analysis revealed that no statistical evidence of correlation was discovered between the polymorphism of rs1801321 and the increased risk of HNC. However, stratified analysis based on ethnicity suggested that rs1801321 polymorphism was related to the decreased risk of HNC among Caucasians (OR = 0.82, 95%CI = 0.72‐0.95 for T vs. G). Conclusions rs1801320 polymorphism was strongly associated with the risk of these two associated cancers, especially with esophageal cancer. Moreover, our results revealed that rs1801321 polymorphism was correlated to the decreased risk of HNC among Caucasians.

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“…Accordingly, the authors concluded that the genetic variability of XRCC3 and/or RAD51 genes might be of relevance with respect to HNC risk. The effects of SNPs in RAD51 and XRCC3 on susceptibility to oral and oropharyngeal squamous cell carcinomas (SCC) and their clinicopathological significance were recently reported by Santos et al (Santos et al, 2019). Specifically, SNPs 135GNC (rs1801320) and 172GNT (rs1801321) in RAD51, and T241M (rs861539) in XRCC3 were genotyped in 81 patients presenting oral SCC, 45 presenting oropharyngeal SCC, and 130 healthy controls.…”

Section: Head and Neck And Oral Cancermentioning

confidence: 99%

Role of Rad51 and DNA repair in cancer: A molecular perspective

Laurini

Marson

Fermeglia

et al. 2020

Pharmacology & Therapeutics

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Clinicopathological significance of SNPs in RAD51 and XRCC3 in oral and oropharyngeal carcinomas

Abstract: Combined effects of RAD51 (rs1801320 and rs1801321) and XRCC3 (rs861539) SNPs with environmental carcinogens (tobacco and alcohol) are associated with oral and oropharyngeal SCC development.

Cited by 14 publications

References 39 publications

Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review

Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review

Genetic Polymorphisms in the RAD51 Gene with a Risk of Head and Neck Cancer and Esophageal Cancer: A Meta-Analysis

Role of Rad51 and DNA repair in cancer: A molecular perspective

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