Clinicopathological significance of tubulointerstitial CD68 macrophages in proliferative lupus nephritis

Chen, Jiejian; Cui, Linlin; Ouyang, Jinge; Wang, Jian; Xu, Weijia

doi:10.1007/s10067-022-06214-y

Cited by 9 publications

(9 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 A). Based on the marker genes expressed by different cells (CSCs (TFF3 31 , AGR2 32 , KRT8 33 , KRT18 34 , 35 ), cancer cells (EPCAM 36 , PIGR 37 , CEACAM5 38 ), CD4 + T cells (IL7R 39 , SARAF 40 , LTB 41 ), CD8 + T cells (CCL5 42 , RORA 43 , GZMA 44 ), fibroblasts (COL1A1 45 , COL3A1 45 , DCN 46 ), B cells (CD79A 47 , MS4A1 48 , CD37 49 ), macrophages (C1QA 50 , LYZ 51 , CD68 52 ), mast cells (KIT 53 , CPA3 54 , TPSAB1 55 ), plasma cells (JCHAIN 42 , MZB1 42 ), neutrophils (S100A8 56 , S100A9 57 , CXCL8 58 ), mesenchymal stem cells (STMN1 59 , PTTG1 60 , HMGB2 61 ), endothelial cells (PLVAP 62 , VWF 63 , PECAM1 64 ), smooth muscle cells (TAGLN 65 , RGS5 66 , ACTA2 67 ), we identified 13 cell types in the CRC samples (Fig. 2 B), with the expression of their marker genes as shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

Wu,

Li,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The prognosis for patients with colorectal cancer (CRC) remains worse than expected due to metastasis, recurrence, and resistance to chemotherapy. Colorectal cancer stem cells (CRCSCs) play a vital role in tumor metastasis, recurrence, and chemotherapy resistance. However, there are currently no prognostic markers based on CRCSCs-related genes available for clinical use. In this study, single-cell transcriptome sequencing was employed to distinguish cancer stem cells (CSCs) in the CRC microenvironment and analyze their properties at the single-cell level. Subsequently, data from TCGA and GEO databases were utilized to develop a prognostic risk model for CRCSCs-related genes and validate its diagnostic performance. Additionally, functional enrichment, immune response, and chemotherapeutic drug sensitivity of the relevant genes in the risk model were investigated. Lastly, the key gene RPS17 in the risk model was identified as a potential prognostic marker and therapeutic target for further comprehensive studies. Our findings provide new insights into the prognostic treatment of CRC and offer novel perspectives for a systematic and comprehensive understanding of CRC development.

show abstract

Section: Resultsmentioning

confidence: 99%

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

Wu,

Li,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Indeed, it has previously been suggested that urine macrophages could be a promising marker for identifying patients with active kidney disease in childhood-onset systemic lupus erythematosus (cSLE) (17). Also, one study showed that the number of CD68 + macrophages in the tubulointerstitium was an independent variable associated with poor renal outcomes in proliferative LN patients with a mean follow-up of 45 months (18). Previous studies showed that macrophage infiltration density was closely associated with renal function decline in both transplanted kidneys and immunocomplex nephritis.…”

Section: Discussionmentioning

confidence: 99%

Prediction of treatment response in lupus nephritis using density of tubulointerstitial macrophage infiltration

Wang,

Lou,

Zhu

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

BackgroundLupus nephritis (LN) is a common disease with diverse clinical and pathological manifestations. A major challenge in the management of LN is the inability to predict its treatment response at an early stage. The objective of this study was to determine whether the density of tubulointerstitial macrophage infiltration can be used to predict treatment response in LN and whether its addition to clinicopathological data at the time of biopsy would improve risk prediction.MethodsIn this retrospective cohort study, 430 patients with LN in our hospital from January 2010 to December 2017 were included. We used immunohistochemistry to show macrophage and lymphocyte infiltration in their biopsy specimens, followed by quantification of the infiltration density. The outcome was the treatment response, defined as complete or partial remission at 12 months of immunosuppression.ResultsThe infiltration of CD68+ macrophages in the interstitium increased in patients with LN. High levels of CD68+ macrophage infiltration in the interstitium were associated with a low probability of treatment response in the adjusted analysis, and verse vice. The density of CD68+ macrophage infiltration in the interstitium alone predicted the response to immunosuppression (area under the curve [AUC], 0.70; 95% CI, 0.63 to 0.76). The addition of CD68+cells/interstitial field to the pathological and clinical data at biopsy in the prediction model resulted in an increased AUC of 0.78 (95% CI, 0.73 to 0.84).ConclusionThe density of tubulointerstitial macrophage infiltration is an independent predictor for treatment response in LN. Adding tubulointerstitial macrophage infiltration density to clinicopathological data at the time of biopsy significantly improves risk prediction of treatment response in LN patients.

show abstract

“…Macrophages are identified in most human renal diseases, suggesting a fundamental pathogenetic role across specific disease entities and affected tissue (Table 1 [3,4] and ). Macrophages are also observed in several renal diseases in animal models used for pathogenetic investigation [3][4][5][6][7][8][9]. Table 3 [10][11][12], provides the immuno-phenotypic markers used to identify major macrophage morphologic subtypes.…”

Section: Monocytes/macrophages In Renal Pathologymentioning

confidence: 99%

“…Increase in endocapillary and mesangial hypercellularity is associated with higher activity of the disease having greater renal dysfunction and is used in Oxford MEST-C classification prognostic scoring system of IgA nephropathy. The role of macrophages and their activation of advanced glycation end products, reactive oxygen species, and inducible nitric oxide synthase (iNOS) have been studied in several glomerular diseases such as IgA nephropathy, diabetic nephropathy, and C3 glomerulonephritis [3][4][5][6][7][8][9]26].…”

Section: Macrophages In Human Proliferative Glomerulonephritismentioning

confidence: 99%

See 1 more Smart Citation

Monocytes and Macrophages in Kidney Disease and Homeostasis

Nachiappa Ganesh,

Garcia,

Truong

2024

IJMS

View full text Add to dashboard Cite

The monocyte–macrophage lineage of inflammatory cells is characterized by significant morphologic and functional plasticity. Macrophages have broad M1 and M2 phenotype subgroups with distinctive functions and dual reno-toxic and reno-protective effects. Macrophages are a major contributor to injury in immune-complex-mediated, as well as pauci-immune, glomerulonephritis. Macrophages are also implicated in tubulointerstitial and vascular disease, though there have not been many human studies. Patrolling monocytes in the intravascular compartment have been reported in auto-immune injury in the renal parenchyma, manifesting as acute kidney injury. Insights into the pathogenetic roles of macrophages in renal disease suggest potentially novel therapeutic and prognostic biomarkers and targeted therapy. This review provides a concise overview of the macrophage-induced pathogenetic mechanism as a background for the latest findings about macrophages’ roles in different renal compartments and common renal diseases.

show abstract

Clinicopathological significance of tubulointerstitial CD68 macrophages in proliferative lupus nephritis

Cited by 9 publications

References 24 publications

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cells

Prediction of treatment response in lupus nephritis using density of tubulointerstitial macrophage infiltration

Monocytes and Macrophages in Kidney Disease and Homeostasis

Contact Info

Product

Resources

About