Clinicopathological significance of vascular endothelial growth factor, thymidine phosphorylase and microvessel density in colorectal cancer

Abstract

Colorectal cancer is a common malignant disease, the incidence of which is increasing worldwide, therefore, identifying novel prognostic factors to improve adjuvant therapeutic strategies or postoperative monitoring is required. Angiogenesis, which is assessed by microvessel density (MVD), is significant in tumor growth and metastasis. However, the association between angiogenesis and clinical outcome remains controversial. In the present study, 84 surgically resected cases of colorectal cancer were examined to clarify the clinicopathological significance of vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and cluster of differentiation (CD)34 expression levels. VEGF expression was identified to be significantly correlated with TP expression (r=0.45; P<0.0001) and MVD in the high VEGF expression group was observed to be significantly greater than that in the low VEGF expression group (P=0.0194). In the Dukes' stage D group, the MVD in the high TP expression group was significantly greater than that in the low TP expression group (P=0.0149). High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34. The results of the present study indicate that VEGF expression may serve as a prognostic factor for colorectal cancer patients exhibiting lymph node metastasis. Furthermore, angiogenesis, as assessed by MVD, is an important prognostic factor for tumor growth at the primary site.

Expression of CD31 in Mycosis Fungoides

“…In our study, we observed that the increased CD31 expression positively correlated with nodal involvement. In a variety of solid tumors, as well as hematological malignancies, increased angiogenesis is associated with poor prognosis (27,28). Surprisingly, in our study, despite the significant correlation between CD31 expression and MF progression, we did not observe any impact on survival.…”

Bevacizumab‐enhanced antitumor effect of 5‐fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2‐specificity protein 1 pathway

“…Accumulating evidence suggests that increased VEGFA exists in high TP‐expressing tumors . However, few papers have focused on the effect of the VEGFA/VEGFR pathway on TP expression.…”

“…5-FU may prefer to be converted to its activated form by TP upregulation, resulting in enhancing cytotoxicity in cancer cells.However, PTX and ADR did not need TP for activation, resulting in TP accumulation, which may cause drug resistance and poor prognosis. Therefore, Bv used with ADR, antimicrotubular drugs or cisplatin may accelerate resistance to chemotherapy by upregulating TP.Accumulating evidence suggests that increased VEGFA exists in high TP-expressing tumors 29,30. However, few papers have focused Bv increased TP expression, which could facilitate VEGFA secretion and promote tumor angiogenesis.…”

Immunohistochemical study of VEGF-A, VEGFR-1, VEGFR-2 and CD34 expression in сolorectal adenocarcinoma progression

“…Y. Kimura et al (2016) установили, что плотность микрососудов, оцененная по экспрессии CD34, значимо выше в метастатической стадии КРА (стадии D по классификации Duke's) и в КРА с высоким уровнем экспрессии VEGF-А, а сочетание высоких показателей экспрессии CD34 и VEGF-А ассоциируется со снижением показателей выживаемости больных КРА [15]. Выводы 1.…”