Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas

Fregnani, Eduardo Rodrigues; Perez, Danyel Elias da Cruz; Almeida, Oslei Paes de; Kowalski, Luiz Paulo; Soares, Fernando Augusto; Alves, Fábio de Abreu

doi:10.1016/j.ijom.2009.11.022

Cited by 114 publications

(169 citation statements)

References 28 publications

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“…In our study, the posterior mandibular area was the preferred location, which was consistent with other studies. 5,7,13,14,19,[22][23][24] Odontoma, also considered a frequent OT, was the third-most common lesion in our study. In some studies, it is shown to be the most frequent lesion, 5,6,12,22 although our study is more consistent with those conducted by Avelar et al, 18 Fernandes et al, 23 Jing et al, 19 Jones and Franklin, 9 Olgac et al, 14 Osterne et al, 13 and Saghravanian et al 15 in presenting an incidence of approximately 17%.…”

Section: Discussionmentioning

confidence: 95%

“…7,14,18,20 No gender-related preponderance was noted in our study, which was different from other studies in which the incidence in the female gender was higher. 5,9,13,23,24 The most frequent clinical presentation was of the solid ameloblastoma (61%) and, histologically, of the follicular variant (33%). This is very similar to what was observed in the studies conducted by Ledesma-Montes et al, 7 Osterne et al, 13 Saghravanian et al 15 and Santos et al 5 However, Fregnani et al 24 observed that the most frequent histological variant was the plexiform, which was observed in 53% of the cases.…”

Section: Discussionmentioning

confidence: 99%

“…5,9,13,23,24 The most frequent clinical presentation was of the solid ameloblastoma (61%) and, histologically, of the follicular variant (33%). This is very similar to what was observed in the studies conducted by Ledesma-Montes et al, 7 Osterne et al, 13 Saghravanian et al 15 and Santos et al 5 However, Fregnani et al 24 observed that the most frequent histological variant was the plexiform, which was observed in 53% of the cases. In our study, the posterior mandibular area was the preferred location, which was consistent with other studies.…”

Section: Discussionmentioning

confidence: 99%

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Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil

et al. 2014

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Odontogenic tumors (OTs) are lesions that develop exclusively on maxillary bones, and form a heterogeneous group. They vary from hamartomatous lesions to benign and malign tumors. Although they are rarely observed in dentistry clinics, it is extremely important for the dentist to be aware of them. The aim of this study was to investigate the incidence of odontogenic tumors diagnosed in the population of Florianópo-lis, Santa Catarina, Brazil. Cases of odontogenic tumors were selected from the anatomopathological diagnostic services at Federal University of Santa Catarina from 1998 to 2011. Clinical data on these cases were collected from biopsy reports and patient files. Seventy-eight cases of odontogenic tumors were surveyed. Of these diagnoses, 51% were keratocystic odontogenic tumors (KCOTs); the remaining cases were mainly ameloblastomas and odontomas. The most frequently observed lesion in this retrospective study was KCOT (more than half of cases). Thus, this study shows that modifying the classification of the OTs altered the frequency of the lesions, possibly making KCOT the most common lesion observed in diagnostic services worldwide.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil

et al. 2014

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“…O padrão radiográfico comumente apresentado pela população brasileira, em contraste com outros estudos, foi é a lesão multilocular, caracterizandose por imagens radiográficas semelhantes a "favos de mel" ou "bolhas de sabão" 11 . Em estudo semelhante realizado na República da Índia 10 , os resultados mostraram uma significativa diferença de idade observada entre as lesões unilocular e multilocular.…”

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“…Esse quadro pode ser justificado em decorrência do crescimento ativo da lâmina dentária ser intenso durante os primeiros anos de vida 10 . Porém, em estudo semelhante realizado na cidade de São Paulo, os autores mostram que nesta população o acometimento é predominantemente na quarta década de vida 11 . Estudando a manifestação desta neoplasia em determinada raça verificou-se uma alta freqüência de pacientes negros acometidos 12 .…”

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Análise Clínica, Radiográfica e Histológica de 122 Casos de Ameloblastomas em uma População Brasileira

Neto¹,

Carvalho²,

Andrade³

et al. 2011

Pesqui. bras. odontopediatria clín. integr.

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Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma

et al. 2020

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Ameloblastoma is a rare odontogenic benign tumor accounting for less than 1% of head and neck tumors. Advanced next generation sequencing (NGS) analyses identified high frequency of BRAF V600E and SMO L412F mutations in ameloblastoma.Despite the existence of whole genomic sequence information from patients with ameloblastoma, entire molecular signature of and the characteristics of ameloblastoma cells are still obscure. In this study, we sought to uncover the molecular basis of ameloblastoma and to determine the cellular phenotype of ameloblastoma cells with BRAF mutations. Our comparative cDNA microarray analysis and gene set enrichment analysis (GSEA) showed that ameloblastoma exhibited a distinct gene expression pattern from the normal tissues: KRAS-responsive gene set is significantly activated in ameloblastoma. Importantly, insulin like growth factor 2 (IGF2), a member of KRAS-responsive genes, enhances the proliferation of an ameloblastoma cell line AMU-AM1 with BRAF mutation. In addition, Toll-like receptor 2 (TLR2) knockdown readily inactivated KRAS-responsive gene sets as well as increases caspase activities, suggesting that TLR2 signaling may mediate cell survival signaling in ameloblastoma cells. Collectively, the findings may help to further clarify the pathophysiology of ameloblastoma and lead to the development of precision medicine for patients with ameloblastoma.

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Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas

Cited by 114 publications

References 28 publications

Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil

Odontogenic tumors: a 14-year retrospective study in Santa Catarina, Brazil

Análise Clínica, Radiográfica e Histológica de 122 Casos de Ameloblastomas em uma População Brasileira

Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma

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