Clinicopathological Study of Gall Bladder Carcinoma with Special Reference to Gallstones: Our 8-year Experience from Eastern India

Hamdani, Nissar Hussain; Qadri, Sumyra Khurshid; Aggarwalla, Ramesh; Bhartia, V. K.; Chaudhuri, Sumit; Debakshi, Sanjay; Baig, Sarfaraz Jalil; Pal, Nishith Kumar

doi:10.7314/apjcp.2012.13.11.5613

Cited by 65 publications

(68 citation statements)

References 21 publications

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“…Histological examination of the tumors revealed findings similar to other studies (Hamdani et al, 2012). Adenocarcinoma not otherwise specified, was found to be most common histological type.…”

Section: Discussionsupporting

confidence: 74%

“…Dipti Kalita*, Leela Pant, Sompal Singh, Gaurav Jain, Madhur Kudesia, Kusum Gupta, Charanjeet Kaur al., 2010), however several studies have confirmed its importance for early detection of this highly aggressive cancer (Hamdani et al, 2012;Mazar et al, 2012). Wang et al (2012) observed that early diagnosis and timely radical surgery are directly correlated to the prognosis of the patients.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Kalita

Pant²,

Singh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Kalita

Pant²,

Singh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In our study, the neoplastic cases commonly presented with pain abdomen comprising 100% cases and the most common site of involvement was right hypochondrium. Barbhuiya et al [13] and Nissar Hussain et al [16] had similar observation for clinical behaviour of gallbladder carcinoma.…”

Section: Discussionsupporting

confidence: 52%

“…Same authors Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] did extensive study on gallbladder carcinoma and found that adenocarcinoma was the most common type microscopically which is also a common observation in our study.…”

Section: Discussionsupporting

confidence: 50%

“…In the studies of Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] the gallstones were found in 77.67%, 72% and 86% cases of gallbladder carcinoma while in our study, 50% cases of gallbladder carcinoma were associated with stones. It suggests that gallstone is an important etiological factor for development of carcinoma which is also supported by the studies of Nissar Hussain et al [16] and Wang et al [17] Pigment stones were the most common type of stones found in our study which is concordant with the finding reported by Kimura et al [18] from Japan.…”

Section: Discussioncontrasting

confidence: 35%

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Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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Background: Gallbladder is one of the most frequently surgically resected organs which stores and concentrates the bile and is involved by both non neoplastic as well as neoplastic diseases. Chronic calculous cholecystitis is the most common benign lesion of gallbladder and pain abdomen is the commonest clinical presentation. Both non neoplastic and neoplastic lesions have similar clinical presentation and overlapping radiological findings. Methods:Total 550 cholecystectomy specimens were received in pathology department. Grossly, formalin fixed specimens were examined carefully and section were given from neck, fundus and body of gallbladder. Whenever it was necessary, additional sections were given. After processing, the H&E stained sections were studied thoroughly. All the clinical details were taken from case papers. Result:The commonly seen non neoplastic lesions were chronic calculous cholecystitis (405 cases), chronic cholecystitis (85 cases), Acute on chronic cholecystitis with or without stones (18 and 3 cases), acute necrotizing cholecystitis (2 cases), eosinophilic cholecystitis (3 cases), follicular cholecystitis (3cases), lymphoplasmacytic cholecystitis (1case), xathogranulomatous cholecystitis (9 cases), cholesterosis (4 cases), mucocele of gall bladder (2 cases), adenomyomatosis (3 cases) and gallbladder cholesterol polyp with cholecystitis (2 cases). Among neoplastic lesions 1 case was adenoma with severe dysplasia and 9 cases were adenocarcinoma. Conclusion:Chronic calculous cholecystitis was the most common lesion and out of 9 cases of carcinoma, 7 cases were diagnosed incidentally. Therefore, histopathological evaluation plays a critical role in identifying incidental gallbladder carcinoma for proper management of patients.

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Characteristics and outcomes of gallbladder cancer patients at the Tata Medical Center, Kolkata 2017–2019

Dutta

Mungle²,

Chowdhury³

et al. 2023

Cancer Medicine

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Background The north and north‐eastern regions of India have among the highest incidence of gallbladder cancer (GBC) in the world. We report the clinicopathological charateristics and outcome of GBC patients in India. Methods Electronic medical records of patients diagnosed with GBC at Tata Medical Center, Kolkata between 2017 and 2019 were analyzed. Results There were 698 cases of confirmed GBC with a median age of 58 (IQR: 50–65) years and female:male ratio of 1.96. At presentation, 91% (496/544) had stage III/IV disease and 30% (189/640) had incidental GBC. The 2‐year overall survival (OS) was 100% (95% CI: 100–100); 61% (95% CI: 45–83); 30% (95% CI: 21–43); and 9% (95% CI: 6–13) for stages I–IV, respectively ( p = <0.0001). For all patients, the 2‐year OS in patients who had a radical cholecystectomy followed by adjuvant therapy ( N = 36) was 50% (95% CI: 39–64), compared to 29% (95% CI: 22–38) for those who had a simple cholecystectomy and/or chemotherapy ( N = 265) and 9% (95% CI: 6–14) in patients who were palliated ( N = 107) ( p = <0.0001). Conclusion The combined surgical/chemotherapy approach for patients with stage II GBC showed the best outcomes. Early detection of GBC remains problematic with the majority of patients presenting with stage III–IV and who have a median survival of 9.1 months. Our data suggests that the tumor is chemoresponsive and multi‐center collaborative clinical trials to identify alternative therapies are urgently required.

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Clinicopathological Study of Gall Bladder Carcinoma with Special Reference to Gallstones: Our 8-year Experience from Eastern India

Cited by 65 publications

References 21 publications

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Clinicopathological Study of Gallbladder Lesions

Characteristics and outcomes of gallbladder cancer patients at the Tata Medical Center, Kolkata 2017–2019

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