Clinicopathological Study of Lichenoid Reactions: A Retrospective Analysis

Chauhan, Ravikant; Srinath, MK; Ali, Neema M; Bhat, Ramesh M; Sukumar, D

doi:10.14260/jemds/2015/812

Cited by 8 publications

(23 citation statements)

References 20 publications

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“…Present study showed a wide age range of involvement from 10 years of age to 78 years of age. This study showed the most common age group as 31 to 50 years of age group with 49.33% cases, which is similar to studies conducted by Hedge et al, Chauhan et al, Garg et al [5][6][7] Present study reported 13 cases (8.78%) in patients till 18 years of age. Chauhan et al, have showed 16.67% cases of less than 18 years of age.…”

Section: Age Distributionsupporting

confidence: 90%

“…Chauhan et al, have showed 16.67% cases of less than 18 years of age. [5][6][7] Thus, lichenoid tissue reactions can be seen in all age groups, though more common in middle aged individuals.…”

Section: Age Distributionmentioning

confidence: 99%

“…Other studies have described nearly equal or more predilection for females. [2][3][4][5][6][7][8][9] A higher predilection of males for the disease could be because of either some geographical variation altering the environmental factors or because of inhibition of many females from reporting for treatment due to the social stigma associated with any skin disease. lichen planus pigmentosus as the second most common variant.…”

Section: Sex Distributionmentioning

confidence: 99%

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A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

2019

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Background: Lichenoid tissue reaction/Interface dermatitis (LTR/ID) refers to a number of clinically diverse, poorly understood and relatively uncommon inflammatory skin diseases. This study was done to understand the histopathological features of lichenoid tissue reactions in skin biopsies and to assess the concordance and disparity between the clinical and histopathological diagnosis of variants of the same.Methods: It was a 3½ years study from January 2014 to June 2017 in the department of Pathology, KIMS, Hubballi. The present study included skin biopsies of clinically diagnosed and suspected cases and histologically diagnosed cases of LTRs. Skin biopsies received were routinely paraffin processed and H&E stained to study the microscopic features.Results: Out of 166 skin biopsies studied, 148 were histologically confirmed as LTR with majority being of lichen planus (LP) (91.22%). Classical lichen planus was the most common variant of lichen planus among lichen planus cases. Male:female ratio was 1.2:1. Clinico-pathological concordance was seen in 88.55% of the cases.Conclusions: Though definite diagnosis can be made on histopathological examination, size of specimen, site of biopsy, nature and depth of biopsy, quality of sections, treatment history and inter-observer variation (both clinically and histologically) should be kept in mind which may lead to clinicopathological discordance.

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Section: Age Distributionsupporting

confidence: 90%

Section: Age Distributionmentioning

confidence: 99%

Section: Sex Distributionmentioning

confidence: 99%

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A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

2019

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“…[17] Accordingly, present study showed hypergranulosis in 40% of cases with lichenoid lesions. In studies of lichenoid tissue reaction or interface dermatitis by other authors, like Chauhan et al [18] , 65.15% of hypergranulosis was noted. Higher number of cases showing hypergranulosis in Chauhan's study may be due to the major fraction of lichen planus cases included, compared to other lichenoid lesions.…”

Section: Discussionmentioning

confidence: 86%

“…Also antigen presenting langerhans cells are found increased just prior to the inflammatory cell accumulation. [17,20] In study of lichenoid lesions, Chauhan et al [18] , Kumar et al [8] and Hegde et al [19] reported 74.24%, 96.6% and 100% of cases showing basal cell liquefactive degeneration respectively. Similarly in studies of lichen planus lesions also, Gurusamy et al [15] , Karumbaiah et al [16] and Parihar et al [9] showed 100% association with vacuolar degeneration of the basal layer.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

Priya

Devi

Karthikeyan

et al. 2018

APALM

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Background: Besides lichen planus various other skin lesions like erythema multiforme, pityriasis lichenoides, etc., show lichenoid reaction pattern. This study was aimed to compare the histological features and number of mast cells in cutaneous lichen planus and lichenoid lesions. Studies have shown increase in mast cell numbers in mucosal lichen planus and lichenoid lesions. Methods: Tissue sections of lichen planus and lichenoid lesions, (forty samples for each group) were studied. All the epidermal, dermal changes and mast cell numbers were noted. Results: Epidermal and dermal changes like acanthosis, hypergranulosis, hyperkeratosis, location of inflammatory cells, severity of inflammation and basement membrane thickness were statistically significant between the two groups. Cases with severe inflammation showed thin and disrupted basement membrane, severe capillary proliferation and severe basal cell vacuolation. The number of mast cells was not significant on comparison between the two groups. Conclusion: The epidermal and dermal changes were consistent with usual histopathological findings in these lesions. The mast cell number was not significant on comparison, which may be due to the common and overlapping mechanisms in the pathogenesis of inflammation in both the groups.

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A clinicopathological study on interface dermatitis

et al. 2022

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Background: Diagnosis of skin disorders that exhibit interface dermatitis is challenging in few scenarios. Despite sincere efforts, clinical examination per se can help us reach a handsome of differential diagnosis but not a gunshot specific diagnosis. Dermatopathology acts as a saviour to clinicians in such cases. Though histopathology is the gold standard, still one cannot make a “specific” diagnosis by histopathology alone because many have overlapping features. Therefore, the present study aims at the importance of clinicopathological correlation. The objectives were to study the clinical and histopathological features of various dermatoses, which exhibit interface dermatitis histopathologically and estimate clinicopathological concordance.Methods: This was a cross-sectional study done on 50 patients attending outpatient department (OPD), with the lesions suggestive of dermatoses known to exhibit interface dermatitis histologically. Strobe guidelines were followed. After a thorough clinical examination, punch biopsies were done and observed microscopically to detect interface dermatitis, if present. Secondary pathological features were studied to assess clinicopathological concordance. Microsoft excel and statistical package for the social sciences (SPSS) 21.0 were used for data analysis.Results: 76.74% cases were cases of lichen planus and its variants. The most common clinical presentation was papules. Among microscopic features, predominant finding was basal cell vacuolar change in epidermis (97.70% cases). Clinicopathological concordance was seen in 43 cases (83%). 7 cases were diagnosed solely based on histological correlation.Conclusions: A myriad of dermatoses exhibit interface dermatitis as a primary pathological feature. Only an apt correlation of clinical features with secondary pathological features can lead to a specific diagnosis from a bunch of differential diagnoses.

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Clinicopathological Study of Lichenoid Reactions: A Retrospective Analysis

Cited by 8 publications

References 20 publications

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

A clinico-pathological study of lichenoid tissue reactions/interface dermatitis

Comparative Study of Histopathological Patterns and Mast Cells in Cutaneous Lichen Planus and Lichenoid Lesions

A clinicopathological study on interface dermatitis

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