Clinicopathological study of Meningioma

Jansari, Trupti R.; Patel, Jigna P.; Chaudhari, Vaibhavi Vinodbhai

doi:10.17511/jopm.2020.i01.02

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…8 Research by Jansari et al ( 2020) also obtained the same result, namely 28 cases (93.33%) were WHO meningioma grade I. 36 Likewise the study of Malik et al (2018), Desai et al (2016), and Karim et al (2016) found that meningioma WHO grade I was the most common, namely 108 cases (85.7%), 45 cases (90%) and 63 cases (90%), respectively. 25,34,35 The presence of FTV was 55.6% (20 cases).…”

Section: Discussionmentioning

confidence: 77%

The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma

Kamelia,

Agus,

Tofrizal

2023

MPI

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Background Meningiomas are the most common primary tumors of the central nervous system. About one-fifth of meningiomas tend to recur. The World Health Organization (WHO) histopathological grade was the most useful morphological predictor of recurrence. Fibrotic tumor vessels (FTV) were detected in nearly half of WHO grade I meningiomas and correlated with vascular density and increased risk of recurrence. Fibulin-2 is an extracellular matrix glycoprotein whose expression increases in traumatic central nervous system injuries and can be used as a marker to differentiate the histopathological grade of meningiomas. This study aimed to determine the association of fibulin-2 expression with histopathological grade and FTV in meningiomas. Methods This research was an observational cross-sectional study. The study sample was 36 cases of meningioma in three Anatomical Pathology laboratories in West Sumatra on period January 2019 to December 2020. Samples obtained from resected meningioma cases were then reevaluated on Hematoxylin Eosin (HE) slides to determine the histopathological grade and FTV. Van-Gieson staining was performed to confirm FTV. Fibulin-2 expression in tumor cells was analyzed using immunohistochemical staining. Bivariate statistical analysis using the Chi-Square test with p<0.05 was considered significant. Result High-risk meningiomas (WHO grade II and III) showed high fibulin-2 expression (62.5%), whereas low-risk meningiomas (WHO grade I) were more abundant with low fibulin-2 expression (75%). The presence of FTV at low fibulin-2 expression was 58.3%. Statistical analysis showed no significant association between fibulin-2 expression with histopathological grade (p=0.077) and FTV (p=1,000). Conclusion In summary, the study showed that fibulin-2 expression was not associated to histopathological grade nor to FTV in meningiomas.

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Section: Discussionmentioning

confidence: 77%

The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma

Kamelia,

Agus,

Tofrizal

2023

MPI

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Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda

Yahaya

2021

Egypt J Neurosurg

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Background Early diagnosis of spinal cord neoplasia serves patients from developing a number of complications and even death. Methods After obtaining ethical approval, retrospectively, a total of 53 tissue blocks of patients attended at the spinal ward were reviewed. Statistical analysis was done using SPSS version 20.0, and p value of less than 0.05 was applied to establish the existence of statistical significance between the compared categorical variables. Results The mean age of the patients was 30.7 ± 15.96 years. Most of the patients 32.1% (n = 17) were aged ≤ 19 years, and majority of the neoplasia 77.3% (n = 41) were extramedullary. Also, majority of the neoplasia 60.4% (n = 32) were benign and the malignant ones were 35.8% (n = 19). The mean duration of onset of symptoms for benign and malignant neoplasia in this study was 13.1 ± 16.4 and 3.4 ± 2.8 years, respectively, with statistical difference (95% CI 2.09–17.35, p = 0.014). Conclusion The patients with spinal cord neoplasia in the present study were of young age, and majority of them had benign neoplasia that were extramedullary located. The mean duration of onset of symptoms for patients with malignant neoplasia was significantly shorter than that of benign neoplasia.

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The Histological Spectrum of Meningiomas

Ahir

Nasit

Ghori

2023

ijsr

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Introduction: Meningiomas are a group of slow-growing, primary intracranial neoplasms, that account for approximately 28 to 30% of the primary central nervous system (CNS) tumors1,2,3,4. They can occur at any age but are most common in middle-aged patients1. Headache is the most common symptom followed by seizures in the cases of intracranial meningiomas. Accurate histopathological diagnosis and grading of these tumors are essential for the management, prognosis, and follow-up of patients. To study Aims and Objectives: incidence, histomorphological types and grade meningiomas according to the WHO grading system. It is a retrospe Material and methods: ctive study comprised of 46 cases of meningioma, which are diagnosed in the Pathology Department. In the present study, Result: the most common age group for presentation is 41-50 years. Male to Female ratio was 1:2.01. Among the chief presenting symptoms, headache is the most common symptom followed by seizures. Meningothelial meningioma was the most common subtype, followed by psammomatous meningioma. Meningiomas are rare slow- Conclusion: growing tumors which are more common in the adult female. A meningothelial variant is the most common variant which is WHO grade 1 meningioma, readily curable by resection. Grade 1 meningiomas have a good prognosis whereas grade 2 and 3 meningiomas have low frequency but come with a poor prognosis

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Clinicopathological study of Meningioma

Cited by 3 publications

References 21 publications

The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma

The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma

Spinal biopsies: a clinicopathologic review of 53 cases diagnosed between 2011 and 2018 at a tertiary hospital in Kampala, Uganda

The Histological Spectrum of Meningiomas

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