Clinicopathological study of pediatric posterior fossa tumors

Prasad, Kadali Satya Vara; Ravi, Divya; Pallikonda, Vijay Kumar; Raman, Bhavana Venkata Satya

doi:10.4103/jpn.jpn_113_16

Cited by 36 publications

(14 citation statements)

References 19 publications

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“…We found that gliomas were the most frequent tumors type, followed by embryonal tumors, as reported in previous publications [5,9]. For topography, the most frequent locations were cerebellum and frontal lobe, as reported in other studies in young adults [9,10]. As expected from the literature [11,12], we found a significant decreasing trend with increasing age for embryonal tumors, and an increasing trend with age for meningioma and other non-neuroepithelial tumors.…”

Section: Discussionsupporting

confidence: 89%

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Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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Introduction We used data from MOBI-Kids, a 14-country international collaborative case-control study of brain tumors (BTs), to study clinical characteristics of the tumors in older children (10 years or older), adolescents and young adults (up to the age of 24). Methods Information from clinical records was obtained for 899 BT cases, including signs and symptoms, symptom onset, diagnosis date, tumor type and location. Results Overall, 64% of all tumors were low-grade, 76% were neuroepithelial tumors and 62% gliomas. There were more males than females among neuroepithelial and embryonal tumor cases, but more females with meningeal tumors. The most frequent locations were cerebellum (22%) and frontal (16%) lobe. The most frequent symptom was headaches (60%), overall, as well as for gliomas, embryonal and 'non-neuroepithelial' tumors; it was convulsions/seizures for neuroepithelial tumors other than glioma, and visual signs and symptoms for meningiomas. A cluster analysis showed that headaches and nausea/ vomiting was the only combination of symptoms that exceeded a cutoff of 50%, with a joint occurrence of 67%. Overall, the median time from first symptom to diagnosis was 1.42 months (IQR 0.53-4.80); it exceeded 1 year in 12% of cases, though no particular symptom was associated with exceptionally long or short delays. Conclusions This is the largest clinical epidemiology study of BT in young people conducted so far. Many signs and symptoms were identified, dominated by headaches and nausea/vomiting. Diagnosis was generally rapid but in 12% diagnostic delay exceeded 1 year with none of the symptoms been associated with a distinctly long time until diagnosis.

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Section: Discussionsupporting

confidence: 89%

“…Intracranial pressure (ICP) is considered the cause of the joint occurrence of headaches and vomiting (without nausea). In general, variations in symptoms prevalence may be related to differences in ICP due to the growing tumor mass [10,18,21] that can exert pressure not only where the tumor is located but also in other areas.…”

Section: Discussionmentioning

confidence: 99%

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

et al. 2020

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“…In a study conducted at Tata Memorial Hospital, the highest incidence was noted in the 19-40 year age group. In a study conducted by Shivraj Nagnath Kanthikar et al [7], the maximum number of CNS tumours were found beyond 40 years of age; among them, 41-50 years age groups people mostly had the lesions. The lowest age group where tumours were noted was 11-20, in that one case was found with glioblastoma multiforme in a male patient at the age of 17 years.…”

Section: Discussionmentioning

confidence: 97%

Study of histopathology of tumors of the central nervous system in a teaching hospital

Sunitha

Akarsh²,

Panchakarla

2022

SR:MS

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Primary central nervous system (CNS) tumours are rare, but they are the second most common in childhood after the most common malignancy, leukaemia. They are considered the most notorious of all cancers. They represent characteristics of a unique, heterogeneous population of neoplasms with benign and malignant tumours and are reported to be less than 2 % of all malignant neoplasms. The aim of the study: To study various tumours of the central nervous system (CNS) Methods: A prospective study on CNS tumours was conducted in the department of Pathology, Guntur Medical College, Guntur, for two years, from June 2011 to May 2013. The data necessary for the study has been retrieved from the histopathology records at the department. 104 cases of CNS tumours were studied in detail, correlating the clinical, radiological and histopathological findings. The department of neurosurgery has provided the biopsy material. The applied nomenclature is that adopted by the 2007 WHO classification. Results: The tumours have been encountered in all age groups, from infants to 80yr elderly persons. The highest frequency is seen in the age group of 41 to 50 years (27 %), followed by 51 to 60 years age group (19 %). The most common tumour reported was astrocytomas constituting 21.1 % (22/104), followed by schwannomas constituting 19.2 % (20/104). least reported was plasmacytoma astrobalstoma 0.9 % (1/104). Conclusion: Adequate imaging by CT/MRI is an essential aid in the diagnosis. Although H&E staining is the mainstay for histopathological diagnosis, immunohistochemistry has played a significant role in diagnostic accuracy. In addition, the judicious use of a panel of selected antibodies is helpful in diagnostically challenging cases

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“…1,3,18 Therefore, it is suggested to approach the clinic from the two points previously mentioned, a) Manifestations of intracranial hypertension: 1. Headache in 55 to 77% of cases [19][20][21][22][23][24][25][26][27] 2. Irritability is more frequent the younger the patient.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

“…"Projectile" vomiting, with a frequency of 39 to 60% in supratentorials, and 73 to 78% in infratentorials. [18][19][20][21][22]29,30 4. Papilledema present in 37% of supratentorial cases, and in 68-90% of infratentorial cases.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Diagnostic assertiveness of cerebellar pilocytic astrocytoma in the pediatric age

Pichardo-Ávalos¹

2022

Mex J Med Res

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Pilocytic astrocytoma of the cerebellum in the pediatric age is the most frequent benign tumor lesion of the nervous system in children according to the WHO. International literature mentions that being low-grade tumors they have a high curative capacity. If the entire tumor is resected, when it is completely removed, survival increases with a high quality of life for children who presented this pathology and was treated on time. However, the delay in diagnosis and therefore in its treatment could generate the possibility of tumor transformation, the malignant nature of the transformed injuries has a very high morbidity and mortality, without mentioning that the degree of cognitive sequelae greatly affects the quality of life of the survivors. That is why the training of pediatric and non-pediatric first contact doctors imply a great responsibility since it gives the population and patients suffering from this nosology the possibility to improve their future life, as well as reduce the cost of the impact caused by the injuries they suffer. On the other hand, these tumors can transform generating devastating prognoses, without taking into account the economic and social repercussions of patients suffering from a low-grade tumor. When it is detected and treated assertively in a timely manner, it offers them greater opportunities than those who did not have such a timely diagnosis.

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Clinicopathological study of pediatric posterior fossa tumors

Cited by 36 publications

References 19 publications

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Study of histopathology of tumors of the central nervous system in a teaching hospital

Diagnostic assertiveness of cerebellar pilocytic astrocytoma in the pediatric age

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