Clinicopathological study of salivary gland tumors: an assessment of 303 patients

Morais, Maria de Lourdes Silva de Arruda; Azevedo, Paulo Roberto Medeiros de; Carvalho, Cyntia Helena Pereira de; Medeiros, Lélia; Lajus, Tirzah Braz Petta; Costa, Antônio de Lisboa Lopes

doi:10.1590/s0102-311x2011000500020

Cited by 20 publications

(15 citation statements)

References 15 publications

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“…The present study's evaluation of 184S GT cases indicates that the majority of tumors were malignant, in contrast to the results of most studies in west and south Iran and other countries (1,4,6,(10)(11)(12)(13) and in agreement with a few studies (14,15).…”

Section: Discussionsupporting

confidence: 83%

Salivary gland tumors: a 15- year report from iran

Taghavi¹,

Sargolzaei²,

Mashhadiabbas³

et al. 2015

TJPATH

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Objective: The aim of this study was to document the clinicopathologic characteristic of salivary gland tumors in Tehran, Iran, over a 15-year period.Material and Method: a retrospective study was conducted on salivary gland tumors diagnosed at two pathology centers of Shahid Beheshti University of Medical Sciences from March 2000 to March 2015. Patient age, sex, tumor site and frequency, as well as clinical and radiographic features and histopathologic diagnosis constituted the main analysis outcome measures. Results:Of the 45429 biopsies conducted over 15 years, 6065 (13.3%) cases were oral and maxillofacial lesions and 937 (15.4%) of these had tumoral diagnoses. Of the 937 tumoral cases, 184 (19.6%) were salivary gland tumors and among 184 cases, 65 (35.3%) were benign and 119 (64.7%) were malignant. Pleomorphic adenoma was the most frequently occurring tumor, comprising 32.6% of all tumors, followed by mucoepidermoid carcinoma (27.1%) and adenoid cystic carcinoma (22.2%). Tumors were frequently reported in minor salivary glands (75%), particularly in the palate with 89 (48.4%) cases. The peak ages of incidence were the fourth and sixth decades of life. Malignant salivary gland tumors showed a predilection for females (72.9%), which was statistically significant (P<0.01). Conclusion:The data presented herein are similar to previously published reports in other countries and other areas of Iran. however, some differences were observed in our study, such as higher overall frequency, a lower mean age of patients with malignant tumors, and the particular sites of involvement. These differences can be attributed to racial factors, the pathology centers of sample collection, and the duration of the studies.

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Section: Discussionsupporting

confidence: 83%

Salivary gland tumors: a 15- year report from iran

Taghavi¹,

Sargolzaei²,

Mashhadiabbas³

et al. 2015

TJPATH

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“…Salivary gland neoplasms are remarkable for their histological diversity and pose a particular challenge to the pathologist because of their complex classification and the rarity of several varieties [1,2]. Most publications in the literature on major and minor salivary gland tumours, find it difficult to evaluate the real frequency and site distribution of salivary gland tumours [2,3]. They are relatively rare, accounting for approximately 2% to 10% of all head and neck tumours [4] worldwide and are more commonly found in the parotid gland.…”

Section: Introductionmentioning

confidence: 99%

Salivary Gland Tumours at Komfo Anokye Teaching Hospital, Ghana

Oti¹,

Donkor²,

Obiri‐Yeboah³

et al. 2013

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In African studies on salivary gland tumours, there are considerable epidemiological differences in different parts of the continent. There is no study of salivary gland tumours from the second largest hospital in Ghana, Komfo Anokye Teaching Hospital. Aim: This study was to look at the prevalence and demographic distribution of salivary gland tumours at the Komfo Anokye Teaching Hospital (KATH). Method: Histopathologically diagnosed salivary gland tumours of consecutive patients were evaluated. The study duration was from 1999 to 2010 October. Result: The total number of salivary gland tumours were 121. Male to female ratio was 1.75:1. Out of the total of 34 salivary malignancies seen, male to female ratio was 1.8:1. Malignant tumour was 28.1% while 71.9% were benign. Mean age for malignancy was 53.5 years (SD = 9.7) and that for benign was 35.5 years (SD = 8.2). Conclusion: The commonest benign tumour of the parotid was Pleomorphic adenoma (48.3%) which is consistent with most of the African and western reports. Warthin’s tumour prevalence was higher than most of the studies from Africa.

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“…Even though Middle East and America presented overall higher prevalence rates than other locations, such as the Europe and Asia, little variation and high imprecision were observed. It is well established that differences in the prevalence of diseases are usually found even within the same country due to epidemiological factors such as genetics, exposition to radiation, viral infection, or consumption of tobacco and alcohol 3,6 . Therefore, not only variability across macro‐geographical regions should be considered, but also differences across micro‐geographical regions.…”

Section: Discussionmentioning

confidence: 99%

“…Mucoepidermoid carcinoma (MEC) is one of the most frequent malignancies of the salivary glands. Studies have shown that MEC may represent up to 45% of all MiSGT 5,6 . Histologically, MEC usually presents two distinct patterns: (a) cystic structures lined by mucin‐producing, intermediate, or epidermoid cells; or (b) solid cellular proliferation of intermediate and epidermoid cells associated with high rates of atypia, anaplasia, and mitoses 7 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of mucoepidermoid carcinoma among intraoral minor salivary gland tumors: A systematic review and meta‐analysis

Poletto

Mello

Melo

et al. 2020

J Oral Pathology Medicine

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This study aimed to synthetize and critically appraise available evidence regarding mucoepidermoid carcinoma (MEC) prevalence among intraoral minor salivary gland tumors (MiSGT). Five main electronic databases and three grey literature databases were searched. The risk of bias (RoB) was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Proportion meta‐analyses were performed. From 1321 studies identified, 82 were included in qualitative synthesis and 80 in meta‐analyses. Sixteen were classified as high, 33 as moderate, and 33 as low RoB. A total of 12 774 MiSGT were found, of which overall MEC prevalence was 16.5% (95% Confidence Interval [95% CI] = 14.8%‐18.4%). Most MiSGT were found in the palate (n = 7115), although MEC pooled prevalence in this anatomic location was only 13.6% (95% CI = 11.7%‐15.6%). The retromolar area presented the highest pooled prevalence (58.9%; 95% CI = 47.0%‐70.3%), followed by gingiva (28.8%; 95% CI = 22.7%‐35.4%) and tongue (27.2%; 95% CI = 21.2%‐33.6%). Regarding geographic location, Middle East presented the highest pooled prevalence (20.8%; 95% CI = 14.8%‐27.6%), followed by America (20.0%, 95% CI = 17.2%‐23%) and Europe (15.6%; 95% CI = 9.2%‐23.5%). Among MiSGT, the MEC overall prevalence was approximately 16.5%. Although most MiSGT were found in the palate, the retromolar area was proportionally more affected by MEC.

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Clinicopathological study of salivary gland tumors: an assessment of 303 patients

Cited by 20 publications

References 15 publications

Salivary gland tumors: a 15- year report from iran

Salivary gland tumors: a 15- year report from iran

Salivary Gland Tumours at Komfo Anokye Teaching Hospital, Ghana

Prevalence of mucoepidermoid carcinoma among intraoral minor salivary gland tumors: A systematic review and meta‐analysis

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