Clinicopathological Study of Skin Adnexal Tumors: A Single Institute Experience

Abstract

Background: Skin adnexal tumors (SATs) encompass a very broad variety of rare dermatopathologic entities. Objective: The aim of the present study was to analyze an incidence and clinicopathological findings of patients with biopsy-proven ASTs. Material and Methods: A retrospective review of all consecutive cutaneous tumors that were diagnosed at the Martin Biopsy Center in Martin from July 2019 to March 2021 was carried out. ASTs have been searched for from this file and studied based on their histologic type and line of differentiation, anatomic distribution, age, and gender. Results: Among over 3,700 skin tumors a total of 38 ASTs in 38 individuals (21 males, 17 females) have been found. The age of the patients ranged from 22-89 years (mean 55.5 y.). The head and neck region was found to be the most common site affected (26/38; 68.4%), followed by extremities (8/38; 21.1%) and trunk (4/38; 10.5%). Tumors of hair follicle origin constituted the largest category (22/38; 57.9%), followed by sweat gland tumors (15/38; 39.5%) and tumors derived from sebaceous glands (1/38; 2.6%). Benign lesions accounted for all 38 cases. Trichoepithelioma was the most frequent lesion found in the category of follicular tumors and poroma was the most common among tumours with sweat gland differentiation. Conclusion: An overall incidence of ASTs is low and in this institutional study they constituted about 1% of all cutaneous neoplasms. ASTs display a marked phenotypic heterogeneity, that is why many published studies have provided divergent results concerning their clinicopathological features.

Five‐year pattern of adnexal tumors of the skin in Ethiopia

“…Most other studies also reported female predominance. 11,12,16,19,[22][23][24][25] A larger number of men was reported by a study in Slovakia which found M : F = 1.2 : 1, 1 an Egyptian study which reported M : F = 1.5 : 1, 16 a Moroccan study which found M : F = These differences must be related to the different proportions of the specific tumor types which have gender disparities. For example, syringoma is reported more commonly in females.…”

“…In our study, the most common tumor identified was poroma (11%), followed by trichilemmal cyst (8.9%), hidradenoma (6.8%), and porocarcinoma (6.8%). The most common tumor found hidradenoma (17.4%) as the most common tumor, followed by poroma (9.8%) and pilomatricoma (9.8%) 9 ; another one done in 2020 by Samaila found poroma (25.8%) as the most frequent tumor, followed by porocarcinoma (13.3%) and hidradenoma (9.8%) 23 ; a Slovakian study found poroma as the most frequent tumor with sweat gland differentiation 1 ; and a…”

“…8 A study in Slovakia reported the most common age to be between 31 and 50 years. 1 A study in Egypt reported the most common age group as the 3rd and 4th…”

“…The vast majority-128/146 (87.6%)-of the skin adnexal tumors identified were solitary in number, whereas 18/146 were multiple. The multiple tumors were syringoma (7) trichoepithelioma (2), sebaceous hyperplasia (1), steatocystoma (3), vellus hair cyst (2), hybrid cyst (1), nevus comedonicus (1), and inverted follicular keratoses (1).…”

“…Most of these tumors are benign, each having a rare malignant counterpart. [1][2][3] They are grouped based on their histogenetic origin and differentiation as those resembling sebaceous glands, sweat glands (eccrine and/or apocrine), or hair follicles. 4 With this, they are classified into four groups: tumors with differentiation toward hair follicles, sebaceous glands, and eccrine or apocrine glands.…”