Clinicopathological study of undifferentiated carcinoma of the parotid gland

Interpretation of treatment outcome in the clinically node‐negative neck in primary parotid carcinoma: A systematic review of the literature

“…Among the latter, undifferentiated and mucoepidermoid carcinoma are found. 10,11 Particular groups are investigated by authors describing patients with normal facial nerve function, N0-neck, or stage I disease. 12-14 A population of patients treated with a conservative parotidectomy is also described.…”

Neuroendocrine Neoplasms of the Head and Neck: Some Suggestions for the New WHO Classification of Head and Neck Tumors

“…Large cell carcinomas also appear to include examples of poorly differentiated squamous cell carcinoma, high-grade mucoepidermoid carcinoma or undifferentiated carcinomas NOS, [35,36]. Some of this confusion can be traced back to the inclusion of large cell carcinomas and small cell carcinomas as part of the spectrum of ''undifferentiated carcinoma'' [21,35] when rigidly applying the 1991 WHO classification of salivary gland tumors [37].…”

Predictors of outcomes in large cell undifferentiated carcinoma of the major salivary glands

“…More specific to poorly differentiated tumors such as LCUC, one should consider the possible variability in pathological review, which is impossible to control for in large database systems. It is worthwhile to mention that the differential diagnosis of a poorly differentiated major salivary gland tumor is wide; careful immunohistochemical testing is indicated to differentiate the lesion from adenocarcinoma, melanoma, or mesenchymal tumors . In addition, differentiated salivary gland tumors are well known to have segments or rests of dedifferentiation, in which areas of the tumor are of high grade and lose many distinguishing histologic charcteristics .…”

“…In addition, differentiated salivary gland tumors are well known to have segments or rests of dedifferentiation, in which areas of the tumor are of high grade and lose many distinguishing histologic charcteristics . Such areas, if not anticipated, can easily lead to misclassification …”