Clinicopathological trends of colorectal carcinoma patients in a tertiary cancer centre in Eastern India

Patra, Tapas; Mandal, Santosh K.; Alam, Neyaz; Murmu, Nabendu

doi:10.1016/j.cegh.2017.04.003

Cited by 9 publications

(3 citation statements)

References 24 publications

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“…Our study population showed a male predominance with a male to female ratio of 2:1. This is in accordance to other studies reporting a higher incidence rate of CRC among males than females [ 17 ]. The male-to-female incidence rate ratio increases progressively across the colon from the caecum to the rectum from close to unity for cecal cancers to two for rectal cancers [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

“…Therefore, CRC screening has been recommended by various advisory committees across the world from ages 50 through 75 [ 15 ]. However, recent data from Western and Asian countries have shown an increase in the number of cases among patients under the screening age of 50 [ 16 , 17 ]. As a result, the US Preventive Services Task Force has issued new guidelines recently that recommend colon cancer screening start at the age of 45 instead of 50 [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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A comparative analysis of the clinicopathological profile of early-onset versus late-onset rectal cancer patients

Trivedi¹,

Chauhan²,

Subham³

et al. 2022

ecancer

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Introduction:Colorectal cancer has been primarily considered a disease of the elderly, but recent data have shown an alarming rise among young people. It has been also suggested that young age is associated with aggressive histopathological characteristics and advanced stages of the disease at diagnosis. As there are few studies and none from our part of the country evaluating the clinicopathological profile of early-onset versus late-onset rectal cancer patients, this analysis was conducted to assess and compare the clinical and pathological characteristics of patients with rectal cancer diagnosed with ages over and below 50 years. Materials and method:The relevant details of all biopsy proven rectal cancer patients undergoing radiotherapy at a tertiary cancer hospital, from January 2017 to December 2019, were collected. All the data were categorised into two groups, an early-onset group (age <50 years) and a late-onset group (age ≥50 years), and comparison of the clinicopathological characteristics between the two groups was made.Results: A total of 224 patients with rectal cancer, 150 male and 74 female, were included in the study. About two-thirds of the patients were less than 50 years of age, with an average age of 42 years. The comparative analysis showed a significantly higher number of young patients presenting with bleeding and pain. Patients below 50 years also had a significantly higher number of adenocarcinoma grade III and clinical stage III than those in the late-onset group. Conclusion:Our study revealed a significant number of early-onset rectal cancer patients. There should be a high index of suspicion in any young patient presenting with symptoms suggestive of rectal malignancy and they should be evaluated promptly.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

A comparative analysis of the clinicopathological profile of early-onset versus late-onset rectal cancer patients

Trivedi¹,

Chauhan²,

Subham³

et al. 2022

ecancer

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“…In both males and females the most common site of colorectal cancer was the rectum which was similar to the results obtained from the study by Patra et al [12]. The cause of the increased incidence of rectal cancers is thought to be the changes in metabolism such as excess bile salt production or intake of low fiber diets [13].…”

Section: Resultssupporting

confidence: 87%

A Study on the Clinicopathological Profile of the Cases of Colorectal Carcinoma

Menon

Sudhan

Sekhar

2021

JPRI

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Aim: To assess the clinicopathological details of patients with colorectal cancer in a tertiary care centre in India and compare it other studies reported in the literature. Study Design: This is a retrospective study conducted on all the patients who were admitted in the period of 2017 to 2020. Place and Duration of Study: Department of Pathology, Saveetha Medical College, Thandalam, Chennai. The data was processed and the manuscript was prepared between June 2020 and January 2021. Methodology: Patient details were collected from the histopathology records and the parameters studied were age, gender, tumour site, histological type, differentiation and tumour stage of the colorectal carcinoma. The sampling was done using the complete enumerate sampling method. The patients diagnosed histopathologically as colorectal carcinoma were included in our study. Results: A total of 51 patients had been admitted in the years 2017, 2018, and 2019 in our institute. There was a female predominance among the patients. The mean age of the patients was lesser than the mean age of colorectal cancer cases in other studies which have been reported in the country. The most common tumour site was rectum in both the sexes and the most common histologic type was adenocarcinoma. The most common histological differentiation was moderate differentiation. Conclusion: The increased incidence in younger patients as compared to previous studies may be attributable to the lifestyle and dietary changes.

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Glyoxylate supplementation ameliorates colitis associated colon cancer progression

Murmu,

Ghosh,

Namani

et al. 2024

Journal Cellular Physiology

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Colon cancer is on the rise in younger adults. Despite multimodal treatment strategies, clinical outcomes in advanced stage colon cancer patients remain poor. Neoadjuvant/adjuvant chemotherapy efficacy is limited due to chemoresistance, toxicity, and negative side effects. Overwhelming evidence supporting the small‐molecule metabolites derived from breakdown of food or microbial sources confer an extensive array of host benefits, including chemo‐preventive role in colon cancer. Our previous study indicated that the introduction of glyoxylate (Glx), an intermediate product of microbial or plant metabolism, exerts a cytotoxic effect in colon cancer cells. This study was designed to evaluate the effects of Glx on colon cancer with molecular insights. For this, we established an AOM/DSS‐induced colitis associated colon cancer model in mice. Supplementation of Glx in vivo reduced colitis associated tumor growth and altered the metabolic characteristics of tumor tissue in mice without initiating any severe liver or renal toxicity. More specifically, intake of glyoxylate accumulated glycine in the colon tissue by elevation of alanine‐glyoxylate transferase (AGXT) activity. Glycine accumulation increased intracellular Ca2+ concentration via glycine receptor activation and dysregulation of Ca2+ homeostasis lead to induction of apoptosis that resulted in arresting tumor growth. Interestingly, elevation of AGXT activity or Glx related specific metabolic pathway provides better survival in colon cancer patients. Collectively, our exclusive findings support the exploration of Glx either as a preventive molecule or its inclusion in the treatment regimens for colon cancer.

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Clinicopathological trends of colorectal carcinoma patients in a tertiary cancer centre in Eastern India

Cited by 9 publications

References 24 publications

A comparative analysis of the clinicopathological profile of early-onset versus late-onset rectal cancer patients

A comparative analysis of the clinicopathological profile of early-onset versus late-onset rectal cancer patients

A Study on the Clinicopathological Profile of the Cases of Colorectal Carcinoma

Glyoxylate supplementation ameliorates colitis associated colon cancer progression

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