Clinicoradiographic evaluation of advanced-platelet rich fibrin block (A PRF + i PRF + nanohydroxyapatite) compared to nanohydroxyapatite alone in the management of periodontal intrabony defects

Abstract

Background: Several bone grafting formulations have been given clinically acceptable outcomes in treating intrabony defects. Platelet rich fibrin (PRF), an autologous platelet concentrate holds potential to be used for regenerative treatment. The purpose of this study was to evaluate clinical and radiographic outcomes in periodontal intrabony defects treated with advanced-PRF block (A PRF + i PRF + nanohydroxyapatite [nHA]) compared to nHA alone. Methods: Twenty-eight sites in chronic periodontitis patients having probing pocket depth (PPD) ≥6 mm and 3 walled intrabony defects (depth of ≥3 mm) were selected, randomly allotted into two groups: Group A was treated with A-PRF block and Group B with nHA (Sybograf™). Clinical parameters including plaque index (PI), gingival index (GI), PPD, relative attachment level (RAL) and radiographically linear and volumetric defect fill were assessed using cone beam computed tomography at baseline and 6 months postoperatively. Results: Intragroup comparison using paired t-test and intergroup comparison using unpaired t-test was done. Group A demonstrated significantly higher reduction in PPD and gain in RAL when compared to Group B (P ≤ 0.05) at the end of 6 months. Similarly gain in bone volume was greater in Group A (0.1 ± 0.05) as compared to Group B (0.04 ± 0.02) (P ≤ 0.05). Conclusion: Advanced-PRF block showed significant clinical and radiographic improvement as compared to nHA alone which depicts that, it may be an ideal graft to be used for the treatment of periodontal intrabony defects.

Novel biomaterial advanced platelet‐rich fibrin plus block for multiple gingival recession

“…Using bone grafts along with PRF can be considered a preventive approach for the loss of labial bone plate, as the thickness of the plate maintains the shape and size of the gingiva which is of prime concern in the esthetic areas. A recent study done using A‐PRF block for regeneration has stated that the use of the block has shown increased osteoblastic activity, with better wound healing and increased tissue remodeling, keeping this notion in mind, A‐PRF block was used in the current study for the management of gingival recession 24 …”

“…A recent study done using A-PRF block for regeneration has stated that the use of the block has shown increased osteoblastic activity, with better wound healing and increased tissue remodeling, keeping this notion in mind, A-PRF block was used in the current study for the management of gingival recession. 24 Based on that concept in the present study, clinical and radiographic assessment was done in multiple recession defects with A-PRF+ block using the VISTA technique.…”

Alveolar Bone Preservation Using a Combination of Nanocrystalline Hydroxyapatite and Injectable Platelet-Rich Fibrin: A Study in Rats

“…Kyyak et al (2021) also revealed that the combination of bovine bone substitute materials with IPRF increases the viability and metabolic activity of human osteoblasts, as well as increases the expression of ALP, BMP-2 at the initial level, and OCN at the final level in vitro [39]. Mallappa et al, (2022) disclosed that the combination of nHA, aPRF, and IPRF materials shows good clinical and radiological results in the treatment of intrabone periodontal defects in humans compared with the single use of nHA [40].…”