Clinostomum complanatum: Anthelmintic potential of curcumin on the infective progenetic metacercarial stage

Rehman, Lubna; Khan, Mohammad Afsar; Beg, M. A.; Wasim, Sobia; Farhat, Faiza; Ahammad, Shareef  P.A.; Abidi, S.M.A.

doi:10.1016/j.exppara.2023.108514

Experimental Parasitology

2023

DOI: 10.1016/j.exppara.2023.108514

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Clinostomum complanatum: Anthelmintic potential of curcumin on the infective progenetic metacercarial stage

Lubna Rehman

Mohammad Afsar Khan

M. A. Beg

et al.

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2024

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Efficacy assessment of miltefosine and curcumin against Clonorchis sinensis infection

Lee,

Chu,

Yoon

et al. 2024

Antimicrob Agents Chemother

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Praziquantel (PZQ) is currently the only approved drug for treating clonorchiasis, but its poor efficacy against Clonorchis sinensis larvae has highlighted the need to develop newer drugs. In this study, to address this challenge, we investigated the anti-parasitic efficacy of miltefosine (MLT), curcumin (CUR), and PZQ against C. sinensis metacercariae (CsMC), newly excysted juvenile worms (CsNEJs), and adults. Larvicidal effects of MLT and CUR surpassed those elicited by PZQ in vitro . These two drugs exerted their effect against both CsMC and CsNEJs in a dose- and time-dependent manner. To confirm the effect of these drugs in vivo , Syrian golden hamsters were orally infected with 100 CsMC and subsequently treated with MLT, CUR, or PZQ at 1 and 4 weeks post-infection (wpi). MLT and CUR reduced the worm recoveries at 1 and 4 wpi, indicating that these drugs were efficacious against both larvae and adult C. sinensis . PZQ was only efficacious against adult worms. Interestingly, both MLT and CUR showed lower levels of C. sinensis- specific IgG responses than the infection control group, implying that worm burden and bile IgG responses could be correlated. These results indicate that MLT and CUR are efficacious against both larval and adult stages of C. sinensis , thereby highlighting their potential for further development as alternative therapeutic options for clonorchiasis.

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Efficacy assessment of miltefosine and curcumin against Clonorchis sinensis infection

Lee,

Chu,

Yoon

et al. 2024

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

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Clinostomum complanatum: Anthelmintic potential of curcumin on the infective progenetic metacercarial stage

Cited by 1 publication

References 50 publications

Efficacy assessment of miltefosine and curcumin against Clonorchis sinensis infection

Efficacy assessment of miltefosine and curcumin against Clonorchis sinensis infection

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