Clitoral circulation in postmenopausal women with sexual dysfunction: A pilot randomized study with hormone therapy

Nappi, Rossella E.; Ferdeghini, Francesca; Sampaolo, P; Vaccaro, Patrizia; Leonardis, Christian De; Albani, Francesca; Salonia, Andrea; Polatti, Franco

doi:10.1016/j.maturitas.2006.04.014

Cited by 44 publications

(43 citation statements)

References 35 publications

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“…It is classified as a selective tissue estrogenic activity regulator [Indhavivadhana et al 2010;Biglia et al 2010], and has been shown to improve vaginal dryness [Nappi et al 2006;Saeideh et al 2010] and may have a favourable effect on sexual function [Modelska and Cummings, 2002].…”

Section: Tibolonementioning

confidence: 99%

A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy

et al. 2017

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There is increasing attention and concern about managing the adverse effects of adjuvant endocrine therapy for women with early breast cancer as the side effects of therapy influence compliance and can impair quality of life (QoL). Most side effects associated with tamoxifen (TAM) and aromatase inhibitors (AIs) are directly related to estrogen deprivation, and the symptoms are similar to those experienced during natural menopause but appear to be more severe than that seen in the general population. Prolonged estrogen deprivation may lead to atrophy of the vulva, vagina, lower urinary tract and supporting pelvic structures, resulting in a range of genitourinary symptoms that can in turn lead to pain, discomfort, impairment of sexual function and negatively impact on multiple domains of QoL. The genitourinary side effects may be prevented, reduced and managed in most cases but this requires early recognition and appropriate treatment. We provide an overview of practical clinical approaches to understanding the pathophysiology and the management of genitourinary symptoms in postmenopausal women receiving adjuvant endocrine therapy for breast cancer.

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Section: Tibolonementioning

confidence: 99%

A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy

et al. 2017

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“…They underwent, in each trimester of pregnancy, to clinical and ultrasonographic evaluation of feto-maternal well-being and each woman filled in Stunkard Figure Rating Scale (FRS) [17], the twofactor Italian McCoy Female Questionnaire (MFSQ) [18,19], and the Beck's Depression Inventory Questionnaire (BDI) [20]. All questions on sex were exclusively related to vaginal intercourse.…”

Section: Methodsmentioning

confidence: 99%

“…The two-factor Italian McCoy Female Sexuality Questionnaire [18,19] is an easy, widely and quick validated tool to adequately discriminate between women with and without sexual dysfunction measuring on a seven-point Likert scale's two dimensions: sexuality (desire, orgasm, arousal, pain and satisfaction) and partnership (partner's sexual health, feeling and relationship; items 8, 9, 10, 11, 19). For both dimensions, the total score was analyzed.…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Stunkard Figure Rating Scale and Sexuality During Pregnancy. A Longitudinal, Pilot Study

Battaglia¹,

Morotti²,

Zanetti³

et al. 2018

Reprod Syst Sex Disord

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Body image and body weight may be associated with sexuality in pregnant women. Twenty pregnant women filled in the two-factor McCoy Female Questionnaire, the Stunkard Figure Rating Scale and the Beck's Depression Inventory Questionnaire. In the pregnant women, the number of intercourses/week and the McCoy Female Questionnaire score for sexuality significantly decreased. The Stunkard Figure Rating Scale evidenced that the "actual body" silhouette score increased during the third trimester of pregnancy and that the women worsened the feeling with their own body image. Changes in body appearance, during pregnancy, and the women's fear of being less attractive for their partners may have lasting effects on sexuality.

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“…In a double-blind crossover study of postmenopausal women tibolone increased vaginal blood flow above placebo when women fantasized about sex (Laan et al, 2001). A recent study demonstrated efficacy in post-menopausal women suffering from female sexual dysfunction (Nappi et al, 2006). Table 2 shows a summary of the hypotheses associated with sexual desire.…”

Section: Hormonesmentioning

confidence: 99%

Neurobiology of Sexual Desire

et al. 2013

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The aim of this paper is to elucidate the anatomical and molecular nature of sexual desire. As such we have focused our attention to the telodiencephalic reproductive complex and the functional interactions with the cortico-limbic circuit that regulate sexual and non-sexual motivation. Major focus of our review was on the animal studies that included hormones, peptides, neurotransmitters and the unique study paradigms that were designed to separate sexual motivation from the consumatory behavior. We also have covered limited number of clinical trials but our primary goal was to review the animal study results. We present rapidly evolving animal research data that we hope will contribute toward the development of new drugs that ameliorate the symptoms of hypoactive sexual desire disorders.

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Clitoral circulation in postmenopausal women with sexual dysfunction: A pilot randomized study with hormone therapy

Cited by 44 publications

References 35 publications

A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy

A clinical guide to the management of genitourinary symptoms in breast cancer survivors on endocrine therapy

Stunkard Figure Rating Scale and Sexuality During Pregnancy. A Longitudinal, Pilot Study

Neurobiology of Sexual Desire

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