2018
DOI: 10.1159/000489385
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Clitoromegaly in Childhood and Adolescence: Behind One Clinical Sign, a Clinical Sea

Abstract: The clitoris is a highly complex organ whose structure has only been clarified in recent years through the use of modern imaging techniques. Clitoromegaly is an abnormal enlargement of this organ. It may be congenital or acquired and is usually due to an excess of androgens in fetal life, infancy, or adolescence. Obvious clitoromegaly in individuals with ambiguous genitalia is easily identifiable, whereas borderline conditions can pass unnoticed. Case reports of clitoromegaly with or without clinical or bioche… Show more

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Cited by 25 publications
(21 citation statements)
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“…These include neurofibromatosis, epidermoid cysts, intradermal nevus, other tumors such as hemangioma or leiomyoma, malignant tumors such as rhabdomyosarcoma, and various syndromes which may be associated with clitoromegaly. 1 Clinical features on examination that suggest a nonhormonal etiology include an irregular or asymmetric clitoris. 1 Further investigations include diagnostic imaging such as ultrasound or MRI.…”
Section: Discussionmentioning
confidence: 99%
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“…These include neurofibromatosis, epidermoid cysts, intradermal nevus, other tumors such as hemangioma or leiomyoma, malignant tumors such as rhabdomyosarcoma, and various syndromes which may be associated with clitoromegaly. 1 Clinical features on examination that suggest a nonhormonal etiology include an irregular or asymmetric clitoris. 1 Further investigations include diagnostic imaging such as ultrasound or MRI.…”
Section: Discussionmentioning
confidence: 99%
“…1 Clinical features on examination that suggest a nonhormonal etiology include an irregular or asymmetric clitoris. 1 Further investigations include diagnostic imaging such as ultrasound or MRI. Genetic evaluation is warranted if an underlying syndrome is suspected.…”
Section: Discussionmentioning
confidence: 99%
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“…Using the definition of mean + 2 SD, we define clitoromegaly as a clitoris greater than 9.9 mm in length. In many neonates, no cause is found (idiopathic clitoromegaly) [15] but, it can also reflect exposure of the fetus to fetal or maternal androgens. Congenital adrenal hyperplasia is the commonest cause of pathological clitoromegaly in the newborn [6].…”
Section: Discussionmentioning
confidence: 99%