2013
DOI: 10.1002/hed.23415
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Clival chordomas: A pathological, surgical, and radiotherapeutic review

Abstract: The preferred treatment for patients with clival chordoma is gross total resection (via endoscopic endonasal surgery when possible) followed by postoperative RT. Treatment at experienced multidisciplinary cranial base centers is key to minimize complications and to enhance the probability of total removal of the tumors.

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Cited by 129 publications
(100 citation statements)
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“…In view of the benefit of minimally invasive surgery to the quality of life of patients with skull base tumors, we believe that endoscopic techniques should be considered appropriate for patients with clival chordoma. 4,30…”
Section: Discussionmentioning
confidence: 99%
“…In view of the benefit of minimally invasive surgery to the quality of life of patients with skull base tumors, we believe that endoscopic techniques should be considered appropriate for patients with clival chordoma. 4,30…”
Section: Discussionmentioning
confidence: 99%
“…The majority of these tumors occur in either the base of the skull (35%) or in the sacrum (50%), and these are typically managed with surgery and/or radiation[2][10]. Their clinical behavior is marked by slow growth and a predilection to recur despite surgical resection.…”
Section: Introductionmentioning
confidence: 99%
“…The inherent proximity of neurovascular structures such as the spinal cord make disease-free resection margins difficult to achieve; recurrence is 100% within 2 years with either inadequate margins or subtotal resection, or radiation therapy alone 4 10. Presurgical radiotherapy may be used to de-bulk disease 11 12. PBT often has a larger role in clival disease control, as high-dose radiation can be delivered precisely to the target area—with reduced damage to surrounding neurovascular tissue—compared to traditional photon radiation 7 9.…”
Section: Discussionmentioning
confidence: 99%