Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Beytebiere, Joshua R.; Greenwell, Ben J.; Sahasrabudhe, Aishwarya; Menet, Jérôme S.

doi:10.1080/21541264.2019.1673636

Cited by 13 publications

(17 citation statements)

References 97 publications

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“…The activation of BMAL1 transcription occurs when RORs are bound, while REV-ERBs suppress BMAL1 transcription [47,48]. This secondary feedback loop is essential for the rhythmic expression of BMAL1 [48,49].…”

Section: Circadian Rhythmmentioning

confidence: 99%

Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

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Although homeostasis is a commonly accepted concept, there is incontrovertible evidence that biological processes and functions are variable and that variability occurs in cycles. In order to explain and understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model has emerged as the first serious challenge to homeostasis, going beyond its homeostatic roots. Circadian rhythm is the predominant variation in the body, and it is a pattern according to which many physiological and pathological events occur. As there is strong experimental and clinical evidence that blood pressure fluctuations undergo circadian rhythm, there is equally strong evidence that targeted time therapy for hypertension provides a better outcome of the disease. The research has gone even further throughout the development and approval process for the use of pulsatile drug release systems, which can be considered as an option for an even more convenient dosage regimen of the medicines needed.

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Section: Circadian Rhythmmentioning

confidence: 99%

Antihypertensives’ Rock around the Clock

Rahić

Tucak

Sirbubalo

et al. 2021

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“…Other data indicate that the mechanisms by which CLOCK:BMAL1 regulates the transcription of core clock genes do not apply to CCGs and suggest that the primary function of CLOCK:BMAL1 is to regulate the chromatin landscape at its enhancers to facilitate the binding of other transcription factors. This implies that CCG expression would be indirect, based on the interaction between the circadian clock and other signaling pathways (Trott and Menet, 2018;Beytebiere et al, 2019).…”

Section: Circadian Rhythms Clock Genes and Their Close Relationshipmentioning

confidence: 99%

The Role of Clock Genes in Fibrinolysis Regulation: Circadian Disturbance and Its Effect on Fibrinolytic Activity

et al. 2020

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The fibrinolytic system is critical during the onset of fibrinolysis, a fundamental mechanism for fibrin degradation. Both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) trigger fibrinolysis, leading to proteolytic activation of plasminogen to plasmin and subsequently fibrin proteolysis. This system is regulated by several inhibitors; plasminogen activator inhibitor-1 (PAI-1), the most studied, binds to and inactivates both tPA and uPA. Through the action of plasmin, this system regulates several physiological processes: embryogenesis, activation of inflammatory cells, cell proliferation and death, synaptic plasticity, wound healing, and others. The deregulated intervention of fibrinolysis in the pathophysiology of various diseases has been widely studied; findings of altered functioning have been reported in different chronic noncommunicable diseases (NCD), reinforcing its pleiotropic character and the importance of its physiology and regulation. The evidence indicates that fundamental elements of the fibrinolytic system, such as tPA and PAI-1, show a circadian rhythm in their plasmatic levels and their gene expression are regulated by circadian system elements, known as clock genes -Bmal, Clock, Cry-, and accessory clock genes such as Rev-Erb and Ror. The disturbance in the molecular machinery of the clock by exposure to light during the night alters the natural light/dark cycle and causes disruption of the circadian rhythm. Such exposure affects the synchronization and functioning of peripheral clocks responsible for the expression of the components of the fibrinolytic system. So, this circadian disturbance could be critical in the pathophysiology of chronic diseases where this system has been found to be deregulated.

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“…the changes in time zones during travel) and subsequently transmit it to the body's cells and tissues (thus influencing the rhythmicity of various processes) (Allada & Chung, 2010). One of the central elements of this brain machinery is the suprachiasmatic nucleus (SCN), primarily entrained with the visual information from the retina, a fact that underlines the importance of the light signals in the generation of the rhythms (Beytebiere et al, 2019;Duda et al, 2020;Reghunandanan & Reghunandanan, 2006).…”

Section: Introductionmentioning

confidence: 99%

The subjective amplitude of the diurnal rhythm matters - chronobiological insights for neuroimaging studies

Zareba,

Scislewska,

Fafrowicz

et al. 2023

Preprint

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Multiple aspects of human physiology, including mood and cognition, are subjected to diurnal rhythms. While the previous neuroimaging studies have focused solely on the morningness-eveningness (ME) preference dichotomy, i.e. the circadian phase, the second key dimension of the diurnal rhythms, i.e. the strength of these preferences (amplitude; AM), has been completely overlooked. Uncovering the neural correlates of AM is especially important considering its link with negative emotionality. Structural T1-weighted neuroimaging data from 79 early (EC) and 74 late (LC) chronotypes were analysed to compare grey matter (GM) volume and cortical thickness. The study aimed to elucidate whether the subjective AM and its interaction with ME was a significant predictor of individual brain structure. Both GM volume and cortical thickness of the left primary visual cortex was negatively correlated with AM scores across the entire sample. Furthermore, EC and LC differed in their association between AM scores and the GM volume in the right middle temporal gyrus, with the positive and negative correlations reported respectively in the two groups. The current study underlines the importance of the visual system in circadian rhythmicity and provides possible neural correlates for AM-related differences in negative affect processing. Furthermore, the presence of the opposite correlations between brain anatomy and AM in the two groups suggests that the behavioural and neuronal chronotype differences might become more pronounced in individuals with extreme diurnal differences in mood and cognition, highlighting the necessity to additionally account for AM in neuroimaging studies.

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Clock-controlled rhythmic transcription: is the clock enough and how does it work?

Cited by 13 publications

References 97 publications

Antihypertensives’ Rock around the Clock

Antihypertensives’ Rock around the Clock

The Role of Clock Genes in Fibrinolysis Regulation: Circadian Disturbance and Its Effect on Fibrinolytic Activity

The subjective amplitude of the diurnal rhythm matters - chronobiological insights for neuroimaging studies

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