Clock genes alterations and endocrine disorders

Angelousi, Anna; Kassi, Eva; Nasiri-Ansari, Νarjes; Weickert, Martin O.; Randeva, Harpal S.; Kaltsas, Gregory

doi:10.1111/eci.12927

Cited by 54 publications

(47 citation statements)

References 129 publications

(323 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During the past several decades, an understanding of the circadian clock and metabolism has made significant advances. Moreover, environments that include cycles of rest and activity, feeding/fasting times and social stressors, have tremendous impacts on human physiology and metabolism (Angelousi et al, 2018). NAFLD, which is recognized as a lipid metabolic disease is closely connected with the circadian clock.…”

Section: Resultsmentioning

confidence: 99%

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

et al. 2019

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is a common disease, which is characterized by the accumulation of triglycerides in the hepatocytes without excess alcohol intake. Circadian rhythms can participate in lipid, glucose, and cholesterol metabolism and are closely related to metabolism seen in this disease. Circadian clock genes can modulate liver lipid metabolism. Desynchrony of circadian rhythms and the influences imparted by external environmental stimuli can increase morbidity. By contrast, synchronizing circadian rhythms can help to alleviate the metabolic disturbance seen in NAFLD. In this review, we have discussed the current research connections that exist between the circadian clock and the metabolism of NAFLD, and we have specifically focused on the key circadian clock genes, Bmal1, Clock, Rev-Erbs, Rors, Pers, Crys, Nocturnin, and DECs.

show abstract

Section: Resultsmentioning

confidence: 99%

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As other nuclear receptors, they also have nongenomic effects such as angiogenesis, microfilament cytoplasmic architecture, cellular respiration [15] and the immune reaction [16]. Thyroid receptors expression shows circadian variation in hepatocytes and adipose tissue in mice [17] and the interruption of this physiological rhythm is another possible mechanism to be considered when analysing the effect of sleep short duration and or misalignment. Some other experimental data supports that hypo and hyperthyroidism affect the clock genes tissue expression; for example, an experimental study showed a significant effect on myocardial metabolism related to the circadian rhythm [18].…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythm deregulation and thyroid dysfunction: results of an observational study on night shift workers

Oțelea

Călugăreanu²

2018

Romanian Journal of Occupational Medicine

View full text Add to dashboard Cite

Context. It has been decades since the circadian variation of the secretion of the thyroid stimulating hormone (TSH) was proven in humans. Even so, there are few studies on human beings that explored the relationship existing between night shift circadian rhythm deregulation and thyroid disorders. Methods. We have revised the occupational medicine files of all employees in a single speciality hospital to conduct an observational study on the prevalence of thyroid disorders in night shift compared to day shift workers. Age, gender, occupational history, body mass index and specialist diagnosed thyroid disorders were recorded. Numerical variables were compared with ANOVA test, and categorical ones with chi test (StatPlus for Mac version v6). Results. Obesity was slightly more prevalent in night shift workers, but not statistically significant. Instead, we found a significant increase in the prevalence of thyroid disorders in night shift workers (X= 7.424, p = 0.006). As this is a mere observational study, our results only contribute to the pool of data concerning the relationship between thyroid dysfunction and night shifts. Conclusions: These results should raise awareness, particularly among occupational physicians and endocrinologists, about the influence of sleep and circadian rhythm deregulation on the raising incidence of thyroid disorders.

show abstract

“…Furthermore, in the dark phase, CRY and PER expression decrease to the CRY-PER repressor complex. This leads to a new cycle of the transcription activation of the CLOCK-BMAL1 complex, which completes the basic auto regulatory loop (8, 13). Otherwise, different modulators display fine tuning of output signals in molecular clock.…”

Section: Circadian Clock Mechanism Clock Genes and Cancermentioning

confidence: 99%

“…Changes in circadian clock increase risk of different cancers in endocrine tissues which require daily proliferation to carry out their activity. Thus, a considerable part of endocrine signals are clock-controlled (8). The dysregulation mechanisms of the circadian clock genes is greatly affected by polymorphic variants of circadian clock-related genes, which can raise human cancer risk through different physiological systems (9).…”

Section: Introductionmentioning

confidence: 99%

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

et al. 2019

View full text Add to dashboard Cite

A major consequence of the world industrialized lifestyle is the increasing period of unnatural light in environments during the day and artificial lighting at night. This major change disrupts endogenous homeostasis with external circadian cues, which has been associated to higher risk of diseases affecting human health, mainly cancer among others. Circadian disruption promotes tumor development and accelerate its fast progression. The dysregulation mechanisms of circadian genes is greatly affected by the genetic variability of these genes. To date, several core circadian genes, also called circadian clock genes, have been identified, comprising the following: ARNTL, CLOCK, CRY1, CRY2, CSNK1E, NPAS2, NR1D1, NR1D2, PER1, PER2, PER3, RORA , and TIMELESS . The polymorphic variants of these circadian genes might contribute to an individual's risk to cancer. In this short review, we focused on clock circadian clock-related genes, major contributors of the susceptibility to endocrine-dependent cancers through affecting circadian clock, most likely affecting hormonal regulation. We examined polymorphisms affecting breast, prostate and ovarian carcinogenesis, in addition to pancreatic and thyroid cancer. Further study of the genetic composition in circadian clock-controlled tumors will be of great importance by establishing the foundation to discover novel genetic biomarkers for cancer prevention, prognosis and target therapies.

show abstract

Clock genes alterations and endocrine disorders

Cited by 54 publications

References 129 publications

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease

Circadian rhythm deregulation and thyroid dysfunction: results of an observational study on night shift workers

An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer

Contact Info

Product

Resources

About