Clofarabine and total body irradiation (TBI) as conditioning regimen for allogeneic stem cell transplantation in high-risk acute leukemia patients: a two-center retrospective cohort study

El‐Cheikh, Jean; Bidaoui, Ghassan; Atoui, Ali; Terro, Khodr; Sharrouf, Layal; Zahreddine, Ammar; Moukalled, Nour; Dalle, Iman Abou; Bazarbachi, Ali; Mohty, Mohamad; Duléry, Rémy

doi:10.1038/s41409-023-01947-z

Cited by 2 publications

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“…Patients with relapsed/refractory (R/R) malignancies received a sequential regimen consisting of Thiotepa-etoposide-cyclophosphamide (TEC) and RIC ( 15 ) in (17%) if younger than 65 and fit for the regimen. Patients with R/R malignancies but older than 65-year-old or unfit for intensive regimens received flu-ATG-TBI ( 12 , 13 , 16 ) (2%), or either Clofarabine (Clo) or flu with 4 to 8 Gy total body irradiation (TBI) ( 17 ) (9%) if older than 65 years or deemed unfit for intensive regimens. All of our patients received cyclophosphamide 50 mg/kg/day at day 3 and day 5 post-transplant ( 18 ).…”

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confidence: 99%

Haploidentical stem cell transplantation with post-transplant cyclophosphamide challenges and outcome from a tertiary care center in Lebanon

et al. 2023

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This letter describes the experience of the American University of Beirut Medical Center in Lebanon with haploidentical stem cell transplant (haplo-SCT) for hematological malignancies in adult patients. Haplo-SCT made it possible through universal and rapid donor availability for most of the adult patients with leukemia or lymphoma not only in the Middle East but also globally. Moreover, the use of post-transplant cyclophosphamide (PTCy) and reduced intensity conditioning (RIC) regimens when indicated improved the outcome and decreased the toxicity of haploidentical stem cell transplant.RIC regimens also allowed its use in the elderly population. Patients from throughout the Middle East come to our center, the American university of Beirut Medical Center, to receive this transformative type of stem cell transplant. In this paper, we discuss the results of haplo-SCT with PTCy done on adult patients with hematological malignancies in our center from 2015 to 2021. The results are encouraging and show that haplo-SCT should be considered more often in the Middle Eastern countries. The subgroup analysis showed the importance of achieving complete remission of the disease prior to transplant to improve outcomes in our center. There is a paucity of literature on the outcomes of haplo-SCT in the Middle East which may contribute to the limited number of centers that offer this type of SCT. Herein, we aim to fill this gap in the hopes of encouraging the implementation of this potentially curative modality of treatment to a larger extent in the Middle East.

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Section: Background and Introductionmentioning

confidence: 99%

Haploidentical stem cell transplantation with post-transplant cyclophosphamide challenges and outcome from a tertiary care center in Lebanon

et al. 2023

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“…Following the evolution of the transplant platform, including new drugs (e.g. Treosulfan or Clofarabine) ( 2 , 3 ) and new Graft Versus Host Disease (GVHD) prophylaxis (e.g. post-transplant cyclophosphamide) a new score for conditioning intensity has been proposed by the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation (ALWP-EBMT) ( 4 ).…”

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Editorial: 50 years of BMT: conditioning regimens and early complications after transplantation

Malagola,

Greco,

El Cheikh

2024

Front. Oncol.

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Clofarabine and total body irradiation (TBI) as conditioning regimen for allogeneic stem cell transplantation in high-risk acute leukemia patients: a two-center retrospective cohort study

Cited by 2 publications

References 21 publications

Haploidentical stem cell transplantation with post-transplant cyclophosphamide challenges and outcome from a tertiary care center in Lebanon

Haploidentical stem cell transplantation with post-transplant cyclophosphamide challenges and outcome from a tertiary care center in Lebanon

Editorial: 50 years of BMT: conditioning regimens and early complications after transplantation

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