Clomiphene citrate–induced severe hypertriglyceridemia

Yaşar, Hamiyet Yılmaz; Ertuğrul, Özden

doi:10.1016/j.fertnstert.2009.03.069

Cited by 11 publications

(8 citation statements)

References 13 publications

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“…However, a more recent report described lower FF HDL levels for oocytes that developed into early-stage embryos compared to those that did not (10). Earlier studies reported longitudinal increases in plasma HDL-cholesterol and ApoA-1 during a standard LDR IVF protocol (44), and hypertriglycedemia following treatment with clomiphene citrate (45). We did not collect baseline specimens and thus we were unable to assess changes over time.…”

Section: Discussionmentioning

confidence: 99%

Variability in the components of high-density lipoprotein particles measured in human ovarian follicular fluid: a cross-sectional analysis

Bloom

Kim

Fujimoto

et al. 2014

Fertility and Sterility

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Objective Assess the variability of follicular fluid (FF) high-density lipoprotein (HDL) particle components. Design FF specimens were collected from two contralateral follicles on the day of oocyte retrieval and analyzed for HDL components. We characterized analytes by age, body mass index (BMI), race and smoking using a cross-sectional design. Biological variability was assessed using two-stage nested analysis of variance. Setting Reproductive health center. Patients One-hundred eighty in vitro fertilization (IVF) patients. Interventions None. Main Outcome Measures Nineteen HDL components including HDL-cholesterol and free (unesterified) and esterified forms, phospholipids, triglycerides, apolipoproteins A-1 and A-2, paraoxonase 1 (PON1) activities, and seven lipophilic vitamins and micronutrients. Results For some analytes, a majority of total measurement variability was attributed to sources between-follicles, suggesting an important role for the integrity of the blood-follicle-barrier and in situ remodeling of plasma derived constituents. For other analytes, variability was mostly attributed to sources between-women, likely indicative of plasma levels. Variability between-follicles decreased with increasing age, differed by BMI and smoking, and generally were lower for Asians and women with diminished ovarian reserve. Conclusions Substantial variability in FF HDL components exist between-follicles among women undergoing IVF, as well as between-women by age, BMI, race, smoking and by infertility diagnosis.

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Section: Discussionmentioning

confidence: 99%

Variability in the components of high-density lipoprotein particles measured in human ovarian follicular fluid: a cross-sectional analysis

Bloom

Kim

Fujimoto

et al. 2014

Fertility and Sterility

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“…This effect induces a significant increase in the secretion of GnRH and subsequent secretions of FSH and LH (26) . Contrary to this, ovarian activities were inhibited in the ewes, i.e., the follicles failed to develop, ovulations did not occur, and the corpora lutea were not formed (27) . No pituitary-stimulatory or gonadotropin-like activity was observed in rats and mice treated with CC (28,29) .…”

Section: Discussionmentioning

confidence: 66%

Histological and Hormonal Study on Effect of Clomiphene Citrate (CC) on Some Reproductive and Embryonic Parameters in Female Mice}

AL-Rekabi¹

2017

IJEIR

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In present study, it was investigated the effect of clomiphene citrate on the ovaries reproductive hormones and embryos of mature female mice, were studied. Female mice treated with (5, 10,50 mg/kg ) daily for 7 days. Results cleared that cross section showed a significant increase (p<0.05) in multi follicular (different numbers )on the right and left ovaries of female mice. In other hand; there were a significant elevation (p<0.05) in the follicle stimulation hormone(FSH), estrogens and progesterone concentration, while, no significant changes were noticed in luteinizing (LH). Conclusions:Clomiphene citrate is the best initial treatment especially in relevance with ovulatory problems (dysfunction), and has a super stimulatory effect on ovulation, thereby increasing the number of recruited follicles in albino female mice rather than affecting the follicular steroidogenic function, and its induce multi follicle ovum forming. Similarly, it has positive affection on gonadotropene hormones, eventually it leads to a twin pregnancy. Combined c with appropriately timed IUI, Clomiphene citrate treatment also increases cycle fecundity in couples with unexplained infertility.

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“…Clomiphene, by its estrogen activity, is believed to increase the production of very-low-density lipoprotein by the liver and reduce the levels of lipoprotein lipase and hepatic lipase, which reduces triglyceride clearance (3-6). The decreased clearance leads to severe hypertriglyceridemia, especially in those with underlying familial hypertriglyceridemia, and subsequent pancreatitis as a result (1,3,(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis due to Clomiphene Citrate-Induced Hypertriglyceridemia: A Case Report and Literature Review

Broome

Thota

2018

AACE Clinical Case Reports

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Objective: Clomiphene citrate-induced hypertriglyceridemia causing acute pancreatitis is rare. The aim of this case report is to alert physicians to the possibility of clomiphene citrate-induced hypertriglyceridemia that can lead to acute, and even chronic, pancreatitis. Methods: We describe a patient with known mild hypertriglyceridemia who presented with acute pancreatitis and severe hypertriglyceridemia after initiation of clomiphene citrate. Results: The patient had mid-epigastric tenderness with radiation around her bilateral flanks in a bandlike distribution. Lab studies showed a triglyceride level greater than 4,425 mg/dL, a lipase level greater than 3,000 U/L, and computed tomography of the abdomen showed acute interstitial edematous pancreatitis. The patient's Naranjo Adverse Drug Reaction score was calculated to be a 7, and was therefore probable as clomiphene being the causative agent. The patient's triglyceride levels improved after initiation of fibrate therapy and discontinuation of clomiphene at first; however, she continued to develop acute episodes of pancreatitis that progressed to chronic pancreatitis despite stopping clomiphene citrate. This is the second report of recurrent pancreatitis with hypertriglyceridemia induced by clomiphene citrate and, in this case specifically, each episode of pancreatitis was associated with hypertriglyceridemia. Conclusion: Clomiphene citrate-induced hypertriglyceridemia rarely occurs and can progress to acute, and even chronic, pancreatitis with significant morbidity. Clomiphene citrate should be used with caution in patients with elevated triglycerides, and should be avoided in patients with triglyceride levels greater than 400 mg/dL.

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Clomiphene citrate–induced severe hypertriglyceridemia

Cited by 11 publications

References 13 publications

Variability in the components of high-density lipoprotein particles measured in human ovarian follicular fluid: a cross-sectional analysis

Variability in the components of high-density lipoprotein particles measured in human ovarian follicular fluid: a cross-sectional analysis

Histological and Hormonal Study on Effect of Clomiphene Citrate (CC) on Some Reproductive and Embryonic Parameters in Female Mice}

Pancreatitis due to Clomiphene Citrate-Induced Hypertriglyceridemia: A Case Report and Literature Review

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