Clomiphene citrate-induced visual hallucinations: a case report

Venkatesh, Ramesh; Gujral, Gaganjeet Singh; Gurav, Prachi; Tibrewal, Shailja; Mathur, Umang

doi:10.1186/s13256-017-1228-0

Cited by 13 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pathophysiology of palinopsia is not clear, but many hypothesis are proposed. One of them is that drugs could alter serotoninergic activity ( 12 – 14 ) or inhibit the synthesis of gamma-aminobutyric acid involved in the generation of action potentials of the visual system ( 16 , 17 ). Another involves a local irritation of the occipito-parietal cortex by surrounding oedema ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Palinopsia Following Acute Unilateral Partial Vestibular Deafferentation: A Case Report

Stafuzza

Landis²,

Guyot

2018

Front. Neurol.

View full text Add to dashboard Cite

Palinopsia is defined as the persistence or reappearance of images after cessation of the visual stimulus. One patient presented episodes of palinopsia after the functional loss of the 3 semicircular canals of the right ear while the otolithic function was preserved. None of classical causes was identified in this patient, intoxications, brain tumors, migraines, psychiatric disorders, etc. For a movement to be perceived as a single event, central processes of temporal integration are necessary to correct the shift between the rapid vestibular information, and the slow visual information. However, it has been shown on animal models that vestibular inputs are slower than normal in case of peripheral deafferentation limited to the canalar function with preservation of the otolithic function, which is the case in this patient. Therefore, we hypothesize that episodes of palinopsia he presents result from the fact that temporal integration processes do not take into account the slower than normal vestibular information due to the peripheral disorder and continue to slow it down. Thus, the patient keeps the visual image in memory until the late arrival of the vestibular information.

show abstract

Section: Discussionmentioning

confidence: 99%

Palinopsia Following Acute Unilateral Partial Vestibular Deafferentation: A Case Report

Stafuzza

Landis²,

Guyot

2018

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…However, in our case the symptoms lasted for < 10 minutes and therefore it was practically not possible for her to undergo fMRI. Visual hallucinations following treatment with ovulation induction drugs like clomiphene citrate due to a similar pathomechanism has also been reported [9, 10]. Keratoconus progression due to increase in estrogen levels following IVF treatment has been reported by Yuksel et al [5].…”

Section: Discussionmentioning

confidence: 75%

Illusory palinopsias induced by in vitro fertilization treatment: a case report

2019

Self Cite

View full text Add to dashboard Cite

Background In the current era, in vitro fertilization, a type of assisted reproductive technology, has been commonly used for infertility management and gestational surrogacy. The techniques that are routinely used in in vitro fertilization include ovarian hyperstimulation to generate multiple eggs, preparation of the ova and sperm, and culture and selection of resultant embryos before transfer into a uterus. These steps increase the chances of successful pregnancy following in vitro fertilization treatment many-fold, especially in young women. Complications reported with in vitro fertilization treatment include multiple gestations, ovarian hyperstimulation syndrome, and birth defects while ocular side effects reported include retinal detachment and progression of keratoconus. We report a case of visual illusory palinopsia following in vitro fertilization treatment in a patient with unexplained infertility. Case presentation A 31-year-old Asian woman was administered in vitro fertilization treatment for her unexplained infertility. She complained of visually disturbing flashes in her peripheral vision during her pregnancy. She described these flashes as occurring usually in the morning hours or while walking, coming in sets of three to four, occurring five–six times a day and lasting for less than 5–10 minutes. Her flashes were not accompanied by other ocular symptoms such as pain, redness, photophobia, or decrease in vision. Her ocular examination was normal. Neuroimaging with magnetic resonance imaging revealed no pathology. A diagnosis of visual illusory palinopsia secondary to in vitro fertilization treatment was made. Conclusion Disturbing visual palinopsia and afterimages can occur following in vitro fertilization treatment for infertility due to increased estrogen levels. This rare ocular side effect caused by in vitro fertilization treatment is not reported in the literature to the best of our knowledge. Gynecologists and/or infertility experts should educate their patients regarding these possible ocular symptoms. Even ophthalmologists should be aware of this rare cause for visual palinopsia.

show abstract

“…According to our method, these ADRs can all be predicted at the threshold = 0.8, and faint and visual disturbances are new side effects clomifene may produce. It has been reported there are several cases that visual complaints may occur during treatment course with clomiphene citrate, such as sudden visual field shimmering, visual hallucinations, and so on. , Diflorasone (DB00223) is a topical corticosteroid used to treat itching and inflammation of the skin (Figure B). Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties.…”

Section: Resultsmentioning

confidence: 99%

Prediction of Adverse Drug Reactions by Combining Biomedical Tripartite Network and Graph Representation Model

Xue

Liao

Shao

et al. 2019

Chem. Res. Toxicol.

View full text Add to dashboard Cite

As one of the primary contributors to high clinical attrition rates of drugs, toxicity evaluation is of critical significance to new drug discovery. Unsurprisingly, a vast number of computational methods have been developed at various stages of development pipeline to evaluate potential adverse drug reactions (ADRs). Despite previous success of these methods on individual ADR or certain drug family, there are great challenges to toxicity evaluation. In this study, a novel strategy was developed to predict the drug−ADR associations by combining deep learning and the biomedical tripartite network. This heterogeneous network contains biomedical linked data of three entities, for example, drugs, targets, and ADRs. For the first time, GraRep, a deep learning method for distributed representations, is introduced to learn graph representations and identify hidden features from the tripartite network which are further used for ADR prediction. Through this approach, drug−ADR associations could possibly be discovered from a systemic perspective. The accuracy of our method is 0.95 based on internal resource validation and 0.88 based on external resource validation. Moreover, our results show the prediction accuracy using the tripartite network is better than the one with bipartite network, suggesting the model performance can be improved with further enrichment on information. According to the result of 10-fold cross validation, the deep learning model outperforms two traditional methods (topology-based measures and chemical structure-based measures). Additionally, predictive models are also constructed using other deep learning methods, and comparable results are achieved. In summary, the biomedical tripartite network-based deep learning model proposed here proves to offer a promising solution for prediction of ADRs.

show abstract

Clomiphene citrate-induced visual hallucinations: a case report

Cited by 13 publications

References 8 publications

Palinopsia Following Acute Unilateral Partial Vestibular Deafferentation: A Case Report

Palinopsia Following Acute Unilateral Partial Vestibular Deafferentation: A Case Report

Illusory palinopsias induced by in vitro fertilization treatment: a case report

Prediction of Adverse Drug Reactions by Combining Biomedical Tripartite Network and Graph Representation Model

Contact Info

Product

Resources

About