Clonal chromosomal abnormalities in cutaneous T-cell lymphoma

Shapiro, P.; Warburton, Dorothy; Berger, Carole L.; Edelson, Richard L.

doi:10.1016/0165-4608(87)90213-5

Cited by 34 publications

(14 citation statements)

References 29 publications

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“…To compare our findings with previously published data, we collated the results of SS patient karyotypes from 27 articles published over the last 26 years (Erkman-Balis and Rappaport, 1974;Edelson et al, 1979;Liang et al, 1980;Poiesz et al, 1980;van Vloten et al, 1980;Nowell et al, 1982Nowell et al, , 1986Whang-Peng et al, 1982;Johnson et al, 1985;Ohyashiki et al, 1985;Schmidt et al, 1985;Barbieri et al, 1986;Gamperl, 1986;Berger and Bernheim, 1987;Shapiro et al, 1987;Berger et al, 1988;Berrebi et al, 1989;D'Alessandro et al, 1990;Solé et al, 1990Solé et al, , 1994Kaltoft et al, 1994;Limon et al, 1995;Brito-Babapulle et al, 1997;Karenko et al, 1997;Mu et al, 1997;Thangavelu et al, 1997;So et al, 2000). All chromosome aberrations were grouped into four categories: aneuploidy (numerical changes), partial deletions (losses), additions (gains), and translocations.…”

Section: Literature Surveymentioning

confidence: 84%

Molecular cytogenetic characterization of Sézary syndrome

Mao

Lillington

Czepulkowski

et al. 2003

Genes Chromosomes & Cancer

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Sézary syndrome (SS) is a rare form of erythrodermic cutaneous T-cell lymphoma with hematological involvement and a poor prognosis. At present little is known about the molecular pathogenesis of this malignancy. To address this issue, we analyzed 28 SS cases through the use of molecular cytogenetic techniques. Conventional cytogenetic analysis showed 12 of 28 cases with clonal chromosome abnormalities (43%). Seven cases had aberrations affecting chromosomes 1 and 17; five demonstrated rearrangement of chromosomes 10 and 14; four presented with an abnormality of 6q. Multiplex-fluorescence in situ hybridization (M-FISH) revealed complex karyotypes in 6 of 17 cases (35%), and recurrent der(1)t(1;10)(p2;q2) and der(14)t(14;15)(q;q?) translocations were each identified in two cases, and confirmed by dual-color FISH. There was an overall difference in the incidence of clonal abnormalities detected by G-banded karyotyping and M-FISH. In addition, comparative genomic hybridization studies revealed chromosome imbalances (CIs) in 9 of 20 cases (45%), with a mean DNA copy number change per sample of 1.95 +/- 2.74, and losses (mean: 1.25 +/- 1.77) more frequent than gains (mean: 0.7 +/- 1.26). The most common CIs noted were loss of 1p, followed by losses of 10/10q, 17p, and 19, and gains of 17q and 18. Furthermore, in conjunction with this study a systematic literature review was conducted, which showed a high frequency and consistent pattern of chromosome changes in SS. These findings suggest that chromosomal instability is common in SS, although there are specific chromosomal abnormalities that appear to be characteristic, and the identification of two different recurrent chromosome translocations provides the basis for further studies.

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Section: Literature Surveymentioning

confidence: 84%

Molecular cytogenetic characterization of Sézary syndrome

Mao

Lillington

Czepulkowski

et al. 2003

Genes Chromosomes & Cancer

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“…In lymphoid malignancies, many del(10)(p) abnormalities have been reported in ATLL cases, 17 and less frequently in cutaneous T-cell lymphoma and mycosis fungoides/ Sézary syndrome. 41,42 Loss of an entire copy of chromosome 10 is common in solid tumors. 34 There was a noticeable correlation with unusual phenotype of ATLL cells, resulting in an aggressive clinical course.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

Itoyama

Chaganti

Yamada

et al. 2001

Blood

104

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Identification of cytogenetic abnormalities is an important clue for the elucidation of carcinogenesis. However, the cytogenetic and clinical significance of adult T-cell leukemia/lymphoma (ATLL) is still unclear. To address this point, cytogenetic findings in 50 cases of ATLL were correlated with clinical characteristics. Karyotypes showed a high degree of diversity and complexity. Aneuploidy and multiple breaks (at least 6) were observed frequently in acute and lymphoma subtypes of ATLL. Breakpoints tended to cluster at specific chromosomal regions, although characteristic cytogenetic subgroups of abnormalities were not found. Of these, aberrations of chromosomes 1p, 1q, 1q10-21, 10p, 10p13, 12q, 14q

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“…DNA cytophotometry, 33-37 nuclear morphometry, 38-41 immunohistochemistry, 42-57 chromosomal studies, [58][59][60] and, more recently, molecular genetic analysis of T-cell clonality 8,[55][56][57][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78] have generated a significant amount of data that suggest their utility not only in the early diagnosis of MF but also potentially in the clinical management of MF patients. How these data may be integrated with light microscopy to aid in the definitive diagnosis of CTCL has not been standardized.…”

Section: Early Diagnosis Of Mf: the Role Of Ancillary Techniquesmentioning

confidence: 99%

Defining early mycosis fungoides

Pimpinelli¹,

Olsen

Santucci³

et al. 2005

Journal of the American Academy of Dermatology

476

378

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This editorial review summarizes the results of 5 meetings sponsored by the International Society for Cutaneous Lymphoma at which the clinicopathologic and ancillary features of early mycosis fungoides were critically examined. Based on this analysis, an algorithm was developed for the diagnosis of early mycosis fungoides involving a holistic integration of clinical, histopathologic, immunopathologic, and molecular biological characteristics. A novel aspect of this algorithm is that it relies on multiple types of criteria rather than just one, for example, histopathology. Before its finalization, the proposed diagnostic algorithm will require validation and possibly further refinement at multiple centers during the next several years. It is anticipated that a more standardized approach to the diagnosis of early mycosis fungoides will have a beneficial impact on the epidemiology, prognostication, treatment, and analysis of clinical trials pertaining to this most common type of cutaneous lymphoma.

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Clonal chromosomal abnormalities in cutaneous T-cell lymphoma

Cited by 34 publications

References 29 publications

Molecular cytogenetic characterization of Sézary syndrome

Molecular cytogenetic characterization of Sézary syndrome

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki

Defining early mycosis fungoides

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