Clonal complex chromosome aberration in non‐ossifying fibroma

Abstract

Cytogenetic information of non-ossifying fibromas (NOFs) is exceptionally limited. This fact relies, in part, on their benign nature but mainly because most cases evolve undetected or there is no need for surgical intervention. We report the case of a NOF arising in the left tibia of a 14-year-old male with an invariable clonal translocation. The karyotype was denoted as 42-46,XY,t(11;3;14)(q23;p21;p11). There are only two previous reported cases of clonally aberrant NOF. Records from additional cases will be essential to assess whether consistent karyotypic aberrations define this lesion.

LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13)

“…However, data supporting a monoclonal origin [12] and the demonstration of clonal chromosome abnormalities in at least some BFHs support a neoplastic pathogenesis [13][14][15][16].…”

Non-ossifying fibroma of the radius: A rare case report

“…While the NOF and the FCD refer to the same histopathological process, the NOF is distinguished from the FCD by its larger size (3 cm) and extension from the cortex into the medullary cavity [2,10] . While the majority of NOFs are asymptomatic, those that are particularly large may cause chronic pain and/or pathologic fracture in the long bones [11,12] . Diagnosis of NOF in the long bones is based upon the characteristic radiographic and clinical appearance, typically the NOF appears as an asymptomatic multiloculated lesion often identified incidentally during radiographic evaluation indicated for another reason [1,11,12] .…”

The Non-ossifying Fibroma: A Case Report and Review of the Literature

“…While the NOF and the FCD refer to the same histopathological process, the NOF is distinguished from the FCD by its larger size ([3 cm) and extension from the cortex into the medullary cavity [2,13]. While the majority of NOFs are asymptomatic, those that are particularly large may cause chronic pain and/or pathologic fracture in the long bones [14,15]. Diagnosis of NOF in the long bones is based upon the characteristic radiographic and clinical appearance, typically the NOF appears as an asymptomatic multiloculated lesion often identified incidentally during radiographic evaluation indicated for another reason [1,14,15].…”

“…While the majority of NOFs are asymptomatic, those that are particularly large may cause chronic pain and/or pathologic fracture in the long bones [14,15]. Diagnosis of NOF in the long bones is based upon the characteristic radiographic and clinical appearance, typically the NOF appears as an asymptomatic multiloculated lesion often identified incidentally during radiographic evaluation indicated for another reason [1,14,15]. When arising in a large, tubular bone, the NOF is always eccentric and ovoid and often results in thinning and expansion of the overlying cortex.…”

“…The presence of clonal chromosomal changes may suggest genetic events associated with tumorigenesis in the reported NOFs. Further study is required to determine whether there are consistent karyotypic aberrations associated with the NOF [15]. To date, no studies have reported clonal rearrangements in NOF of the mandible.…”