Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma

Kobayashi, Jun’ichi; Hirohashi, Yoshihiko; Torigoe, Toshihiko; Michifuri, Yoshitaka; Yamamoto, Takashi; Tamura, Yasuaki; Kamiguchi, Kenjiro; Miyazaki, Akira; Yamaguchi, Akira; Hariu, Hiroyuki; Hiratsuka, Hiroyoshi; Sato, Noriyuki

doi:10.1016/j.humimm.2008.11.004

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…Previously, we have also made many efforts to establish cell lines from human OSCCs (13,18,24). In this study, using approximately 20 biopsy or surgically-resected specimens of different patients with OSCCs, finally we succeeded in establishing only one cell line (OTM).…”

Section: Discussionmentioning

confidence: 99%

“…In another study, we also established a novel autologous tumor-CTL pair of OSCC which recognized tumor cells in an HLA-A24-restricted manner (13). However, little is known about TAAs recognized by autologous CTLs in OSCC, and very few attempts have been made at identifying these yet-unknown TAAs because the establishment of such autologous pairs of tumor cell lines and CTLs requires great effort.…”

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confidence: 99%

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Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma

Okamoto

Miyazaki

Kobayashi

et al. 2017

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma

Okamoto

Miyazaki

Kobayashi

et al. 2017

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“…The aforementioned cell lines were authenticated by JCRB Cell Bank using STR methods. The other human oral neoplastic cell lines, OLC-01 (23) and OSC-70 (24) were gifted from Dr S. Kawashiri (Kanazawa University, Kanazawa, Japan). All cell lines were cultured in high glucose DMEM (Sigma-Aldrich; MilliporeSigma) supplemented with 10% heat-inactivated fetal bovine serum (FBS) at 37˚C in a humidified atmosphere containing 5% CO 2 .…”

Section: Methodsmentioning

confidence: 99%

Exploring stage‑specific embryonic antigen 3 involvement in oral cancer progression and as a potential target for taxane‑based chemotherapy

Ide,

Kawano,

Shirakawa

et al. 2023

Oncol Rep

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Despite significant advancements in therapeutic approaches, oral neoplasms remain formidable and life-threatening conditions that affect a substantial number of individuals worldwide. Within oral malignancies, a subset of cancer stem cells (CSCs) represent a crucial population responsible for tumor initiation and progression. The identification of reliable markers for the detection and characterization of CSCs in solid tumors, particularly in the context of oral cancers, remains an ongoing challenge. Stage-specific embryonic antigen 3 (SSEA3), previously associated with mesenchymal stem cells and linked to the progression of breast neoplasms and poor prognosis, has yet to be comprehensively elucidated in the context of oral malignancies. The present study aimed to investigate the expression and properties of SSEA3 in 16 distinct subsets of human oral neoplastic cell lines, classified as either CD44 positive (+) or CD44 negative (-). For the first time, SSEA3 was examined as an indicator of tumorigenicity and resistance to taxane-derived chemotherapeutic agents. In the majority of oral neoplastic cell lines analyzed, SSEA3 was expressed in a small population of CD44(+) cells. Significantly, SSEA3(+) cells exhibited heightened proliferative activity and upregulated expression of genes associated with stem cells compared with SSEA3(-) cells. The aforementioned findings suggested that SSEA3 may contribute to the evolution and progression of oral malignancies by fostering tumor growth. Furthermore, SSEA3(+) cells displayed increased sensitivity to taxane-based pharmaceuticals, indicating the potential for SSEA3 to be a viable target in the treatment schema for oral cavity neoplasms. In conclusion, the present study provides novel insight into the role of SSEA3 in the progression and management of oral neoplasms, potentially paving the way for more effective therapeutic approaches.

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Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells

Hirohashi¹,

Torigoe²,

Hirai³

et al. 2010

Experimental and Molecular Pathology

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Clonal diversity of cytotoxic T lymphocytes that recognize autologous oral squamous cell carcinoma

Cited by 3 publications

References 28 publications

Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma

Induction and Analysis of Cytotoxic T-Lymphocytes that Recognize Autologous Oral Squamous Cell Carcinoma

Exploring stage‑specific embryonic antigen 3 involvement in oral cancer progression and as a potential target for taxane‑based chemotherapy

Establishment of shared antigen reactive cytotoxic T lymphocyte using co-stimulatory molecule introduced autologous cancer cells

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