Clonal dominance among synovial tissue-infiltrating lymphocytes in arthritis

Chatila, M; Pandolfi, Franco; Stamenkovich, Ivan; Kurnick, James T.

doi:10.1016/0198-8859(90)90026-l

Cited by 17 publications

(3 citation statements)

References 6 publications

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“…However, some studies were able to detect oligoclonality ofsynovial T cells selected for the ability to grow in IL-2 alone (20, 21) . Even when oligoclonality was claimed, however, there was no consensus on the specific dominant rearrangement in different patient samples (22,23). Taken together, these studies indicate that there is minimal oligoclonality in the rheumatoid synovium, although selection for IL-2-responsive T cells may induce outgrowth of a limited number ofclones.…”

Section: Introductionmentioning

confidence: 82%

T cell receptor V beta gene bias in rheumatoid arthritis.

Jenkins

Nikaein²,

Zimmermann³

et al. 1993

J. Clin. Invest.

115

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Polymerase chain reaction (PCR) technology was employed to examine peripheral blood and synovial T increased synovial expression of V/i14 was found, but only in the synovial fluid samples. Reduced expression of V#1, Vj64, V/i5.1, V/i10, V,816, and V/i19 was also observed in synovial T cells. These results indicate that biased V,8 gene utilization in different peripheral compartments of RA patients can be observed in unselected T cell populations, and are consistent with the conclusion that populations of T cells expressing these V/i gene products may be involved in the pathogenesis of the disease. (J. Clin. Invest. 1993. 92:2688-2701

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Section: Introductionmentioning

confidence: 82%

T cell receptor V beta gene bias in rheumatoid arthritis.

Jenkins

Nikaein²,

Zimmermann³

et al. 1993

J. Clin. Invest.

115

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“…6,7,12 As such, the finding of an (oligo)clonal T-cell population in the synovial tissue of patients with RA or other inflammatory rheumatic diseases even in absence of a T-cell malignancy can occur. [20][21][22] Tachibana et al 12 reported the detection of an identical clone in synovial fluid and LN by SB analysis in a patient with T-zone lymphoma. However, up until now no primary skin lesions of patients with MF have been analyzed for direct comparison.…”

Section: Discussionmentioning

confidence: 98%

Clonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritis

Sandberg¹,

Abdouni²,

Lam³

et al. 2004

Journal of the American Academy of Dermatology

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“…The presence of T-cell receptor (TCR) restriction at the joints has also been described, suggesting T-cell attack of a joint antigen. It may also prove important in terms of predicting poor response to conventional therapy and severity of disease [ 21 , 22 ].…”

Section: Rheumatoid Arthritis and Immunologic Pathwaysmentioning

confidence: 99%

Interleukin-6 in Rheumatoid Arthritis

Pandolfi

Franza

Carusi

et al. 2020

IJMS

Self Cite

148

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The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.

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Clonal dominance among synovial tissue-infiltrating lymphocytes in arthritis

Cited by 17 publications

References 6 publications

T cell receptor V beta gene bias in rheumatoid arthritis.

T cell receptor V beta gene bias in rheumatoid arthritis.

Clonal identity between skin and synovial tissue in a case of mycosis fungoides with polyarthritis

Interleukin-6 in Rheumatoid Arthritis

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