Clonal Evolution in Two Patients with Autoimmune Disease and Lymphoreticular Neoplasia

Abstract

SUMMARY.-Two cases are described, one with proven lympbosarcoma and doubtful autoimmune disease, and the second with the reverse situation, in which circulating abnormal mononuclear cells showed PHA responsiveness and an abnormal chromosomal constitution (clonal evolution). These findings are discussed in the light of previous cytogenetic studies of lymphoreticular neoplasia and autoimmune disease and the relationship between these two conditions.